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Anesth Analg 2003;97:1108-1116
© 2003 International Anesthesia Research Society


PAIN MEDICINE

The Role of N-Methyl-D-Aspartate (NMDA) Receptors in Pain: A Review

Andrei B. Petrenko, MD, Tomohiro Yamakura, MD PhD, Hiroshi Baba, MD PhD, and Koki Shimoji, MD PhD, FRCA

From the Department of Anesthesiology, Niigata University School of Medicine, Asahimachi 1–757, Niigata 951–8510, Japan

Address correspondence to Andrei B. Petrenko, MD, Department of Anesthesiology, Niigata University School of Medicine, Asahimachi 1–757, Niigata 951–8510, Japan. Address email to abpetr{at}med.niigata-u.ac.jp

There is accumulating evidence to implicate the importance of N-methyl-D-aspartate (NMDA) receptors to the induction and maintenance of central sensitization during pain states. However, NMDA receptors may also mediate peripheral sensitization and visceral pain. NMDA receptors are composed of NR1, NR2 (A, B, C, and D), and NR3 (A and B) subunits, which determine the functional properties of native NMDA receptors. Among NMDA receptor subtypes, the NR2B subunit-containing receptors appear particularly important for nociception, thus leading to the possibility that NR2B-selective antagonists may be useful in the treatment of chronic pain.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.