JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (104)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Petrenko, A. B.
Right arrow Articles by Shimoji, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Petrenko, A. B.
Right arrow Articles by Shimoji, K.
Related Collections
Right arrow Pain
Right arrow Pharmacology

Anesth Analg 2003;97:1108-1116
© 2003 International Anesthesia Research Society

PAIN MEDICINE

The Role of N-Methyl-D-Aspartate (NMDA) Receptors in Pain: A Review

Andrei B. Petrenko, MD, Tomohiro Yamakura, MD PhD, Hiroshi Baba, MD PhD, and Koki Shimoji, MD PhD, FRCA

From the Department of Anesthesiology, Niigata University School of Medicine, Asahimachi 1–757, Niigata 951–8510, Japan

Address correspondence to Andrei B. Petrenko, MD, Department of Anesthesiology, Niigata University School of Medicine, Asahimachi 1–757, Niigata 951–8510, Japan. Address email to abpetr{at}med.niigata-u.ac.jp

There is accumulating evidence to implicate the importance of N-methyl-D-aspartate (NMDA) receptors to the induction and maintenance of central sensitization during pain states. However, NMDA receptors may also mediate peripheral sensitization and visceral pain. NMDA receptors are composed of NR1, NR2 (A, B, C, and D), and NR3 (A and B) subunits, which determine the functional properties of native NMDA receptors. Among NMDA receptor subtypes, the NR2B subunit-containing receptors appear particularly important for nociception, thus leading to the possibility that NR2B-selective antagonists may be useful in the treatment of chronic pain.




This article has been cited by other articles:


Home page
 NeurologyHome page
R. Y. Yuan, J. J. Sheu, J. M. Yu, W. T. Chen, I. J. Tseng, H. H. Chang, and C. J. Hu
Botulinum toxin for diabetic neuropathic pain: A randomized double-blind crossover trial
Neurology, April 28, 2009; 72(17): 1473 - 1478.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pediatric Oncology NursingHome page
M. Conway, N. White, C. St. Jean, W. T. Zempsky, and K. Steven
Use of Continuous Intravenous Ketamine for End-Stage Cancer Pain in Children
Journal of Pediatric Oncology Nursing, March 1, 2009; 26(2): 100 - 106.
[Abstract] [PDF]

Home page
 Anesth. Analg.Home page
J. Zakine, D. Samarcq, E. Lorne, M. Moubarak, P. Montravers, S. Beloucif, and H. Dupont
Postoperative Ketamine Administration Decreases Morphine Consumption in Major Abdominal Surgery: A Prospective, Randomized, Double-Blind, Controlled Study
Anesth. Analg., June 1, 2008; 106(6): 1856 - 1861.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
N. M. Elsharnouby, H. E. Eid, N. F. Abou Elezz, and A. N. Moharram
Intraarticular Injection of Magnesium Sulphate and/or Bupivacaine for Postoperative Analgesia After Arthroscopic Knee Surgery
Anesth. Analg., May 1, 2008; 106(5): 1548 - 1552.
[Abstract] [Full Text] [PDF]

Home page
 JAOA: Journal of the American Osteopathic AssociationHome page
G. H. Pharo and L. Zhou
Controlling Cancer Pain With Pharmacotherapy
J Am Osteopath Assoc, December 1, 2007; 107(suppl_7): ES22 - ES32.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
B. H. Gabra, F. K. Kessler, J. K. Ritter, W. L. Dewey, and F. L. Smith
Decrease in N-Methyl-D-aspartic Acid Receptor-NR2B Subunit Levels by Intrathecal Short-Hairpin RNA Blocks Group I Metabotropic Glutamate Receptor-Mediated Hyperalgesia
J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 186 - 194.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Zeng, L. M. Thomson, S. A. Aicher, and G. W. Terman
Primary Afferent NMDA Receptors Increase Dorsal Horn Excitation and Mediate Opiate Tolerance in Neonatal Rats.
J. Neurosci., November 15, 2006; 26(46): 12033 - 12042.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
R. Staud, C. J. Vierck, M. E. Robinson, and D. D. Price
Overall fibromyalgia pain is predicted by ratings of local pain and pain-related negative affect--possible role of peripheral tissues
Rheumatology, November 1, 2006; 45(11): 1409 - 1415.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K. Solt, E. I. Eger II, and D. E. Raines
Differential Modulation of Human N-Methyl-d-Aspartate Receptors by Structurally Diverse General Anesthetics.
Anesth. Analg., May 1, 2006; 102(5): 1407 - 1411.
[Abstract] [Full Text] [PDF]

Home page
 J Am Acad Orthop SurgHome page
T. T. Horlocker, S. L. Kopp, M. W. Pagnano, and J. R. Hebl
Analgesia for total hip and knee arthroplasty: a multimodal pathway featuring peripheral nerve block.
J. Am. Acad. Ortho. Surg., March 1, 2006; 14(3): 126 - 135.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. K. Pareek, J. Keller, S. Kesavapany, H. C. Pant, M. J. Iadarola, R. O. Brady, and A. B. Kulkarni
Cyclin-dependent kinase 5 activity regulates pain signaling
PNAS, January 17, 2006; 103(3): 791 - 796.
[Abstract] [Full Text] [PDF]

Home page
 JAOA: Journal of the American Osteopathic AssociationHome page
G. H. Pharo and L. Zhou
Pharmacologic Management of Cancer Pain
J Am Osteopath Assoc, November 1, 2005; 105(suppl_5): S21 - S28.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. O. Udesky, N. Z. Spence, R. Achiel, C. Lee, and P. Flood
The Role of Nicotinic Inhibition in Ketamine-Induced Behavior
Anesth. Analg., August 1, 2005; 101(2): 407 - 411.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K. Hara, K. Minami, and T. Sata
The Effects of Tramadol and Its Metabolite on Glycine, {gamma}-Aminobutyric AcidA, and N-Methyl-d-Aspartate Receptors Expressed in Xenopus Oocytes
Anesth. Analg., May 1, 2005; 100(5): 1400 - 1405.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
F. Adam, M. Chauvin, B. Du Manoir, M. Langlois, D. I. Sessler, and D. Fletcher
Small-Dose Ketamine Infusion Improves Postoperative Analgesia and Rehabilitation After Total Knee Arthroplasty
Anesth. Analg., February 1, 2005; 100(2): 475 - 480.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
Y. Tamura, M. Hoshiyama, K. Inui, H. Nakata, Y. Qiu, Y. Ugawa, K. Inoue, and R. Kakigi
Facilitation of A{delta}-fiber-mediated acute pain by repetitive transcranial magnetic stimulation
Neurology, June 22, 2004; 62(12): 2176 - 2181.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
G. Popescu and A. Auerbach
The NMDA Receptor Gating Machine: Lessons from Single Channels
Neuroscientist, June 1, 2004; 10(3): 192 - 198.
[Abstract] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.