JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Durmus, M.
Right arrow Articles by Ersoy, M. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Durmus, M.
Right arrow Articles by Ersoy, M. O.
Related Collections
Right arrow Trauma
Right arrow Pharmacology

Anesth Analg 2003;97:1377-1380
© 2003 International Anesthesia Research Society

ANESTHETIC PHARMACOLOGY

The Effects of Single-Dose Dexamethasone on Wound Healing in Rats

Mahmut Durmus, MD*, Erol Karaaslan, MD*, Erdogan Ozturk, MD*, Mukaddes Gulec, MD{dagger}, Mustafa Iraz, MD{ddagger}, Naci Edali, MD PhD§, and M. Ozcan Ersoy, MD PhD*

Departments of *Anaesthesiology and Reanimation, {dagger}Biochemistry, {ddagger}Pharmacology, and §Pathology, Inonu University School of Medicine, Malatya, Turkey

Address correspondence and reprint requests to Mahmut Durmus, MD, Department of Anaesthesiology, Inonu University, School of Medicine, 44069 Malatya, Turkey. Address e-mail to mdurmus{at}inonu.edu.tr

Dexamethasone effectively decreases the incidence of nausea and vomiting among pediatric and adult patients. In this study, we evaluated the effects of single-dose dexamethasone on wound healing in a prospective, randomized, experimental animal model. Anesthesia was induced with thiopental 100 mg/kg intraperitoneally. Dexamethasone 1 mg/kg was administered intraperitoneally in a dexamethasone group, and physiological saline was administered in a control group. Collagenization, epithelization, and fibroblast content were significantly less in the dexamethasone group compared with the control group (P values of 0.002, 0.041, and 0.023, respectively). The vascularity and the degree of inflammatory cells were more intense in the dexamethasone group compared with the control group (P values of 0.023 and 0.002, respectively). The white blood cell count was similar in the control (7.84 ± 2.09) and dexamethasone (6.98 ± 2.12) groups. The mean hydroxyproline level was 0.72 ± 0.13 mg/g in the dexamethasone and 1.03 ± 0.19 mg/g in the control group. Hydroxyproline levels were significantly less in the dexamethasone group (P = 0.001). We conclude that dexamethasone at 1 mg/kg may have negative effects on wound healing.

IMPLICATIONS: We evaluated the effects of dexamethasone on wound healing in a prospective, randomized, experimental animal model. Our results show that dexamethasone at 1 mg/kg may have negative effects on wound healing.




This article has been cited by other articles:


Home page
 JAMAHome page
C. Czarnetzki, N. Elia, C. Lysakowski, L. Dumont, B. N. Landis, R. Giger, P. Dulguerov, J. Desmeules, and M. R. Tramer
Dexamethasone and Risk of Nausea and Vomiting and Postoperative Bleeding After Tonsillectomy in Children: A Randomized Trial
JAMA, December 10, 2008; 300(22): 2621 - 2630.
[Abstract] [Full Text] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
A. Gercek, O. Yildirim, D. Konya, S. Bozkurt, S. Ozgen, T. Kilic, A. Sav, and N. Pamir
Effects of Parenteral Fish-Oil Emulsion (Omegaven) on Cutaneous Wound Healing in Rats Treated With Dexamethasone
JPEN J Parenter Enteral Nutr, May 1, 2007; 31(3): 161 - 166.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. S. Kim, C. J. Cote, C. Cristoloveanu, A. G. Roth, P. Vornov, M. A. Jennings, J. P. Maddalozzo, and C. Sullivan
There Is No Dose-Escalation Response to Dexamethasone (0.0625-1.0 mg/kg) in Pediatric Tonsillectomy or Adenotonsillectomy Patients for Preventing Vomiting, Reducing Pain, Shortening Time to First Liquid Intake, or the Incidence of Voice Change
Anesth. Analg., May 1, 2007; 104(5): 1052 - 1058.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.