Anesth Analg 2003;97:1769-1772
© 2003 International Anesthesia Research Society
CRITICAL CARE AND TRAUMA
The Dose-Related Effects of Ketamine on Mortality and Cytokine Responses to Endotoxin-Induced Shock in Rats
Takumi Taniguchi, MD*,
Yasuhiro Takemoto, MD ,
Hiroko Kanakura, MD ,
Yoko Kidani, MD , and
Ken Yamamoto, MD
Departments of *Emergency and Critical Care Medicine and
Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
Address correspondence and reprint requests to Takumi Taniguchi, MD, Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. Address e-mail to taniyan{at}med.kanazawa-u.ac.jp
IMPLICATIONS: IV administered ketamine dose-independently inhibited hypotension, metabolic acidosis, and proinflammatory cytokine responses, and improved survival rates of rats receiving a single IV bolus of endotoxin.
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