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Anesth Analg 2003;97:1769-1772
© 2003 International Anesthesia Research Society

CRITICAL CARE AND TRAUMA

The Dose-Related Effects of Ketamine on Mortality and Cytokine Responses to Endotoxin-Induced Shock in Rats

Takumi Taniguchi, MD*, Yasuhiro Takemoto, MD{dagger}, Hiroko Kanakura, MD{dagger}, Yoko Kidani, MD{dagger}, and Ken Yamamoto, MD{dagger}

Departments of *Emergency and Critical Care Medicine and {dagger}Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan

Address correspondence and reprint requests to Takumi Taniguchi, MD, Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. Address e-mail to taniyan{at}med.kanazawa-u.ac.jp

IMPLICATIONS: IV administered ketamine dose-independently inhibited hypotension, metabolic acidosis, and proinflammatory cytokine responses, and improved survival rates of rats receiving a single IV bolus of endotoxin.




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Low-dose ketamine affects immune responses in humans during the early postoperative period
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T. Taniguchi, H. Kanakura, Y. Takemoto, and K. Yamamoto
The Antiinflammatory Effects of Ketamine in Endotoxemic Rats During Moderate and Mild Hypothermia
Anesth. Analg., April 1, 2004; 98(4): 1114 - 1120.
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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.