This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Lewis, A. K. Articles by Roth, R. Search for Related Content PubMed PubMed Citation Articles by Lewis, A. K. Articles by Roth, R. Related Collections Operating Rooms Surgery Anesthetic Techniques

---

GENERAL ARTICLES

The Effect of Hemispheric Synchronization on Intraoperative Analgesia

Department of Anesthesiology, Mount Sinai School of Medicine, New York, New York

Address correspondence and reprint requests to Irene Osborn, MD, Box 1010, 1 Gustave L. Levy Place, New York, NY 10029. Address e-mail to Irene.osborn{at}mssm.edu

In this double-blinded randomized study, we sought to confirm that patients undergoing general anesthesia who were exposed to a hemispheric synchronization (Hemi-Sync) musical recording during surgery had a smaller analgesia requirement, as was suggested in a previous study. Bispectral index monitoring was used to adjust depth of hypnosis, and hemodynamic variables were used to determine analgesia administration. Consented patients underwent either laparoscopic bariatric or one-level lumbar disk surgery. After endotracheal intubation and application of headphones, baseline heart rate and arterial blood pressure were established. Isoflurane was titrated to maintain sedation on the basis of a target bispectral index range of 40–60, and 25-µg increments of fentanyl were administered in response to increases in heart rate and systolic arterial blood pressure. Bariatric patients who listened to Hemi-Sync required one-third less fentanyl than the control group (mean [SD]: 0.015 [0.01] vs 0.024 µg · kg^-1 · min^-1 [0.01]) (P = 0.009). It is interesting to note that lumbar patients in the experimental and control groups required similar amounts of fentanyl (0.012 [0.01] vs 0.015 µg · kg^-1 · min^-1 [0.01]). End-tidal isoflurane concentration was similar for Hemi-Sync and blank-tape patients (bariatric, 0.74% (0.14) vs 0.77% (0.21); lumbar, 0.36% [0.16] vs 0.39% [0.12]). The bariatric patients in this study demonstrated that Hemi-Sync may be an innovative intraoperative supplement to analgesia.

IMPLICATIONS: The purpose of this study was to determine the decrease in analgesia requirement for patients listening to hemispheric synchronization (musical tones) while under general anesthesia. We demonstrated that bariatric patients who listened to hemispheric synchronization had a smaller analgesia requirement than those who listened to a blank tape.

This article has been cited by other articles:

				P. Szmuk, N. Aroyo, T. Ezri, G. Muzikant, M. Weisenberg, and D. I. Sessler Listening to Music During Anesthesia Does Not Reduce the Sevoflurane Concentration Needed to Maintain a Constant Bispectral Index Anesth. Analg., July 1, 2008; 107(1): 77 - 80. [Abstract] [Full Text] [PDF]