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Anesth Analg 2004;98:1201-1207
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000112306.71113.5E

EDITORIAL

The Failure of Retrograde Autologous Priming of the Cardiopulmonary Bypass Circuit to Reduce Blood Use After Cardiac Surgical Procedures

Glenn S. Murphy, MD, Joseph W. Szokol, MD, Martin Nitsun, MD, David A. Alspach, MD, Michael J. Avram, PhD, Jeffery S. Vender, MD, Timothy V. Votapka, MD, and Todd K. Rosengart, MD

From the Department of Anesthesiology, Evanston Northwestern Healthcare, Evanston, Illinois

Address correspondence and reprint requests to Glenn S. Murphy, MD, Evanston Northwestern Healthcare, Department of Anesthesiology, 2650 Ridge Ave., Evanston, IL 60201. Address email to dgmurphy{at}core.com

Abstract

Hemodilution during cardiopulmonary bypass (CPB) is a primary risk factor for blood transfusion in cardiac surgical patients. Priming of the CPB circuit with the patients’ own blood (retrograde autologous priming, RAP) is a technique used to limit hemodilution and reduce transfusion requirements. We designed this study to examine the impact of RAP on perioperative blood product use. Using a retrospective cohort study design, the medical records of all patients undergoing CPB (excluding circulatory arrest cases) by a single surgeon were examined. Data were collected over a 24-mo period when RAP was routinely used as a blood conservation strategy (RAP group, n = 257). This group was compared with a cohort of patients during the 24 mo immediately preceding the introduction of RAP into clinical practice (no RAP group, n = 288). A small, statistically insignificant reduction in the percentage of patients receiving packed red blood cells was observed in the RAP group (44% versus 51% no RAP, P = 0.083). No differences were found between the groups in the number of units of packed red blood cells, platelets, or fresh frozen plasma transfused throughout the perioperative period. These results suggest that overall, RAP does not offer a clinically important benefit as a blood conservation technique.

IMPLICATIONS: Priming of the cardiopulmonary bypass circuit with the patients’ own blood (retrograde autologous priming) resulted in insignificant reductions in blood use in a large, unselected group of patients undergoing cardiac surgical procedures.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2004 by the International Anesthesia Research Society.