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TECHNOLOGY, COMPUTING, AND SIMULATION

Comparative Evaluation of Narcotrend^TM, Bispectral Index^TM, and Classical Electroencephalographic Variables During Induction, Maintenance, and Emergence of a Propofol/Remifentanil Anesthesia

Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany

Address correspondence and reprint requests to Gunter N. Schmidt, MD, Department of Anesthesiology, University Hospital Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. Address e-mail to guschmid{at}uke.uni-hamburg.de

In the present study, we sought to compare the abilities of Narcotrend^TM (NT) with the Bispectral Index^TM (BIS^TM) electroencephalographic system to monitor depth of consciousness immediately before induction of anesthesia until extubation during a standardized anesthetic. We investigated 26 patients undergoing laminectomy. Investigated states of anesthesia were: awake, loss of response, loss of eyelash reflex, steady-state anesthesia, first reaction, and extubation during emergence. NT, BIS^TM, spectral edge frequency, median frequency, relative power in , , , ß, and hemodynamics were recorded simultaneously. The ability of all variables to distinguish between awake versus loss of response, awake versus loss of eyelash reflex, awake versus steady-state anesthesia, steady-state anesthesia versus first reaction and extubation were analyzed with the prediction probability. Effects of remifentanil during propofol infusion were investigated with Friedman’s and post hoc with Wilcoxon’s test. Only NT and BIS^TM were able to distinguish all investigated states accurately with a prediction probability >0.95. After start of remifentanil infusion, only hemodynamics changed statistically significantly (P < 0.05). NT and BIS^TM are more reliable indicators for the assessment of anesthetic states than classical electroencephalographic variables and hemodynamics, whereas the analgesic potency of depth of anesthesia could not be detected by NT and BIS^TM.

IMPLICATIONS: The modern electroencephalographic monitoring systems Narcotrend^TM and Bispectral Index^TM are more reliable indicators for the assessment of anesthetic states than classical electroencephalographic and hemodynamic variables to predict anesthetic conditions from before induction of anesthesia until extubation during a standardized anesthetic regime with propofol and remifentanil. The analgesic potency of depth of anesthesia could not be detected by Narcotrend^TM and Bispectral Index^TM.

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