| JOURNAL HOME | CME HOME | THIS MONTH | PAST ISSUES | ETOC | COLLECTIONS |
| AUTHORS | REVIEWERS | EDITORIAL BOARD | FEEDBACK | RSS | HELP |
| ||||||||||||||
| ||||||||||||||
|
|
|
|
||||||||||||
|
||||||||||||||
o
lu, MD*
, MD*
*Department of Anaesthesiology, and the
Department of Biostatistics, Trakya University Medical Faculty, Edirne, Turkey
Address correspondence to Alparslan Turan, MD, Trakya University Medical Faculty, Department of Anesthesiology and Reanimation, 22030 Edirne, Turkey. Address email to alparslanturan{at}yahoo.com
We investigated, in a randomized, placebo-controlled, double-blind study, the efficacy and safety of gabapentin on pain after abdominal hysterectomy and on tramadol consumption in patients. The 50 patients were randomized to receive either oral placebo or gabapentin 1200 mg 1 h before surgery. Anesthesia was induced with propofol and maintained with sevoflurane in 50% N2O/O2 with a fresh gas flow of 2 L/min (50% N2O in O2) and fentanyl (2 µg/kg). All patients received patient-controlled analgesia with tramadol with a 50 mg initial loading dose, 20 mg incremental dose, 10-min lockout interval, and 4-h limit of 300 mg. The incremental dose was increased to 30 mg if analgesia was inadequate after 1 h. Patients were studied at 4, 8, 12, 16, 20, and 24 h for visual analog (VAS) pain scores, heart rate, peripheral oxygen saturation, mean arterial blood pressure, respiratory rate, sedation, and tramadol consumption. The VAS scores in the sitting and supine position at 1, 4, 8, 12, 16, and 20 h were significantly lower in the gabapentin group when compared with the placebo group up to 20 h after surgery. The tramadol consumption at 12, 16, 20, and 24 h and total tramadol consumption were significantly less in the gabapentin group when compared with placebo group. Sedation scores were similar at all the measured times. There were no differences between groups in adverse effects. Preoperative oral gabapentin decreased pain scores and postoperative tramadol consumption in patients after abdominal hysterectomy.
IMPLICATIONS: This randomized, controlled trial examined the effects of preoperative oral gabapentin 1200 mg on postoperative pain and tramadol consumptions. We conclude that preoperative oral gabapentin is effective in reducing postoperative pain scores and tramadol consumption in patients after abdominal hysterectomy.
This article has been cited by other articles:
|
|
 |
|
  E. R. Viscusi, T. J. Gan, J. B. Leslie, J. F. Foss, M. D. Talon, W. Du, and G. Owens Peripherally Acting Mu-Opioid Receptor Antagonists and Postoperative Ileus: Mechanisms of Action and Clinical Applicability Anesth. Analg., June 1, 2009; 108(6): 1811 - 1822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. McQuay, K. H. Poon, S. Derry, and R. A. Moore Acute pain: combination treatments and how we measure their efficacy Br. J. Anaesth., July 1, 2008; 101(1): 69 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Van Elstraete, M. Tirault, T. Lebrun, I. Sandefo, J.-C. Bernard, B. Polin, P. Vally, and J.-X. Mazoit The Median Effective Dose of Preemptive Gabapentin on Postoperative Morphine Consumption After Posterior Lumbar Spinal Fusion Anesth. Analg., January 1, 2008; 106(1): 305 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. F. Kong and M. G. Irwin Gabapentin: a multimodal perioperative drug? Br. J. Anaesth., December 1, 2007; 99(6): 775 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Gajraj Pregabalin: Its Pharmacology and Use in Pain Management Anesth. Analg., December 1, 2007; 105(6): 1805 - 1815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Agarwal, S. Dhiraaj, S. Pawar, R. Kapoor, D. Gupta, and P. K. Singh An Evaluation of the Efficacy of Gabapentin for Prevention of Catheter-Related Bladder Discomfort: A Prospective, Randomized, Placebo-Controlled, Double-Blind Study Anesth. Analg., November 1, 2007; 105(5): 1454 - 1457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Koc, D. Memis, and N. Sut The Preoperative Use of Gabapentin, Dexamethasone, and Their Combination in Varicocele Surgery: A Randomized Controlled Trial Anesth. Analg., October 1, 2007; 105(4): 1137 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Tiippana, K. Hamunen, V. K. Kontinen, and E. Kalso Do Surgical Patients Benefit from Perioperative Gabapentin/Pregabalin? A Systematic Review of Efficacy and Safety Anesth. Analg., June 1, 2007; 104(6): 1545 - 1556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Turan, P. F. White, B. Karamanlioglu, and Z. Pamukcu Premedication with Gabapentin: The Effect on Tourniquet Pain and Quality of Intravenous Regional Anesthesia Anesth. Analg., January 1, 2007; 104(1): 97 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fassoulaki, A. Melemeni, A. Paraskeva, and G. Petropoulos Gabapentin attenuates the pressor response to direct laryngoscopy and tracheal intubation Br. J. Anaesth., June 1, 2006; 96(6): 769 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Rowbotham Editorial II: Gabapentin: a new drug for postoperative pain? Br. J. Anaesth., February 1, 2006; 96(2): 152 - 155. [Full Text] [PDF]
|
|
|
|
|
|
A. Turan, G. Kaya, B. Karamanlioglu, Z. Pamukcu, and C. C. Apfel Effect of oral gabapentin on postoperative epidural analgesia Br. J. Anaesth., February 1, 2006; 96(2): 242 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bonnet and E. Marret Influence of anaesthetic and analgesic techniques on outcome after surgery Br. J. Anaesth., July 1, 2005; 95(1): 52 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Menigaux, F. Adam, B. Guignard, D. I. Sessler, and M. Chauvin Preoperative Gabapentin Decreases Anxiety and Improves Early Functional Recovery from Knee Surgery Anesth. Analg., May 1, 2005; 100(5): 1394 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
