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Anesth Analg 2004;98:1471-1472
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000108132.95279.DD

OBSTETRIC ANESTHESIA

General Anesthesia for Cesarean Delivery in a Patient with Paroxysmal Nocturnal Hemoglobinuria and Thrombocytopenia

Klaus Kjaer, MD, Michele Comerford, MD, and Farida Gadalla, MD

From the Department of Anesthesiology, Weill Medical College of Cornell University, New York, New York

Address correspondence and reprint requests to Klaus Kjaer, MD, Weill Cornell Medical Center, Department of Anesthesiology, 525 E. 68th St. Suite M-325, New York, NY 10021. Address email to kkjaer{at}hotmail.com

Pregnancy in patients with paroxysmal nocturnal hemoglobinuria (PNH) increases the risk of complement activation, hemolysis, and thrombosis. We describe the anesthetic management of a patient with PNH who underwent general anesthesia for cesarean delivery. Steroids, heparin, and blood products were administered early to minimize the likelihood of a hematologic emergency.

IMPLICATIONS:Pregnancy in patients with paroxysmal nocturnal hemoglobinuria increases the risk of hemolysis, thrombosis, anemia, and thrombocytopenia. We describe the anesthetic management of a patient with paroxysmal nocturnal hemoglobinuria and thrombocytopenia who underwent general anesthesia for cesarean delivery.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2004 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2004 by the International Anesthesia Research Society.