This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Donahue, B. S. Search for Related Content PubMed PubMed Citation Articles by Donahue, B. S.

---

CARDIOVASCULAR ANESTHESIA

Factor V Leiden and Perioperative Risk

Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee

Address correspondence and reprint requests to Brian S. Donahue, MD, 504 Oxford House, Department of Anesthesiology, Vanderbilt University, Nashville, TN 37232. Address e-mail to brian.donahue{at}vanderbilt.edu

Factor V Leiden (FVL) is the most common known inherited cause of thrombophilia; it is present in approximately 5% of the Caucasian population. Although the risk of venous thrombosis associated with this polymorphism in various medical settings is well described, its effect on perioperative risk is only beginning to be explored. Specifically, there are few studies addressing the potential risks of FVL in the surgical population, in which both hemorrhagic and thrombotic complications convey substantial clinical and economic significance. There are speculations and unproven hypotheses regarding FVL in this population, and these therefore highlight the need to comprehensively address this issue. This review will describe the physiology of the FVL mutation, briefly clarify its risk in the nonsurgical setting, and assess current data regarding FVL in noncardiac and cardiac surgery. Finally, a summary of current clinical evidence and a plan for more detailed investigation of this potentially significant risk factor will be proposed.

This article has been cited by other articles:

				K. J. Hogan, J. K. Burmester, M. D. Caldwell, Q. H. Hogan, D. B. Coursin, D. N. Green, R. M.R. Selzer, T. P. Broderick, D. A. Rusy, M. Poroli, et al. Perioperative Genomic Profiles Using Structure-Specific Oligonucleotide Probes Clin. Med. Res., September 1, 2009; 7(3): 69 - 84. [Abstract] [Full Text] [PDF]

				T. Domi, D. S. Edgell, B. W. McCrindle, W. G. Williams, A. K. Chan, D. L. MacGregor, A. Kirton, and G. A. deVeber Frequency, Predictors, and Neurologic Outcomes of Vaso-occlusive Strokes Associated With Cardiac Surgery in Children Pediatrics, December 1, 2008; 122(6): 1292 - 1298. [Abstract] [Full Text] [PDF]

				S. T. Morozowich, B. S. Donahue, and I. J. Welsby Genetics of coagulation: considerations for cardiac surgery. Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2006; 10(4): 297 - 313. [Abstract] [PDF]

				M. V. Podgoreanu and D. A. Schwinn New Paradigms in Cardiovascular Medicine: Emerging Technologies and Practices: Perioperative Genomics J. Am. Coll. Cardiol., December 6, 2005; 46(11): 1965 - 1977. [Abstract] [Full Text] [PDF]

				J. A. Connor Factor V Leiden and Its Effect on Children With Cardiac Pathology Journal of Pediatric Oncology Nursing, May 1, 2005; 22(3): 176 - 181. [Abstract] [PDF]