JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Donahue, B. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Donahue, B. S.

Anesth Analg 2004;98:1623-1634
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000113545.03192.FD

CARDIOVASCULAR ANESTHESIA

Factor V Leiden and Perioperative Risk

Brian S. Donahue, MD, PhD

Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee

Address correspondence and reprint requests to Brian S. Donahue, MD, 504 Oxford House, Department of Anesthesiology, Vanderbilt University, Nashville, TN 37232. Address e-mail to brian.donahue{at}vanderbilt.edu

Factor V Leiden (FVL) is the most common known inherited cause of thrombophilia; it is present in approximately 5% of the Caucasian population. Although the risk of venous thrombosis associated with this polymorphism in various medical settings is well described, its effect on perioperative risk is only beginning to be explored. Specifically, there are few studies addressing the potential risks of FVL in the surgical population, in which both hemorrhagic and thrombotic complications convey substantial clinical and economic significance. There are speculations and unproven hypotheses regarding FVL in this population, and these therefore highlight the need to comprehensively address this issue. This review will describe the physiology of the FVL mutation, briefly clarify its risk in the nonsurgical setting, and assess current data regarding FVL in noncardiac and cardiac surgery. Finally, a summary of current clinical evidence and a plan for more detailed investigation of this potentially significant risk factor will be proposed.




This article has been cited by other articles:


Home page
 PediatricsHome page
T. Domi, D. S. Edgell, B. W. McCrindle, W. G. Williams, A. K. Chan, D. L. MacGregor, A. Kirton, and G. A. deVeber
Frequency, Predictors, and Neurologic Outcomes of Vaso-occlusive Strokes Associated With Cardiac Surgery in Children
Pediatrics, December 1, 2008; 122(6): 1292 - 1298.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
S. T. Morozowich, B. S. Donahue, and I. J. Welsby
Genetics of coagulation: considerations for cardiac surgery.
Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2006; 10(4): 297 - 313.
[Abstract] [PDF]

Home page
 J Am Coll CardiolHome page
M. V. Podgoreanu and D. A. Schwinn
New Paradigms in Cardiovascular Medicine: Emerging Technologies and Practices: Perioperative Genomics
J. Am. Coll. Cardiol., December 6, 2005; 46(11): 1965 - 1977.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pediatric Oncology NursingHome page
J. A. Connor
Factor V Leiden and Its Effect on Children With Cardiac Pathology
Journal of Pediatric Oncology Nursing, May 1, 2005; 22(3): 176 - 181.
[Abstract] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2004 by the International Anesthesia Research Society.