This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Chinzei, M. Articles by Hanaoka, K. Search for Related Content PubMed PubMed Citation Articles by Chinzei, M. Articles by Hanaoka, K. Related Collections Monitoring (Non-cardiac) Pharmacology

---

TECHNOLOGY, COMPUTING, AND SIMULATION

Change in Bispectral Index During Epileptiform Electrical Activity Under Sevoflurane Anesthesia in a Patient with Epilepsy

Mieko Chinzei, MD, PhD^*,, Shigehito Sawamura, MD, PhD, Masakazu Hayashida, MD, PhD, Takayuki Kitamura, MD^*, Hisayoshi Tamai, MD, and Kazuo Hanaoka, MD, PhD^*

*Surgical Centre, Graduate School of Medicine, and Department of Anesthesiology and Pain Relief Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Address correspondence and reprint requests to Mieko Chinzei, MD, PhD, Surgical Center, Institute of Medical Science, The University of Tokyo Hospital 113-8655, 7-3-1 Hongo Bunkyo-ku, Tokyo, Japan. Address e-mail to mieko{at}bme.rcast.u-tokyo.ac.jp

We observed abnormal fluctuation in Bispectral Index (BIS) caused by repeated alternations between two electroencephalographic (EEG) waveform patterns in a patient with a recent history of epileptic seizure under sevoflurane anesthesia. The repetitive development of the abnormal EEG changes (slow with or without spike) and the fluctuation in BIS disappeared almost immediately after administration of anticonvulsants. BIS may give useful information not only on the sedative-hypnotic state, but also on the development of and recovery from abnormal epileptiform EEG activity.

IMPLICATIONS: During epileptiform electroencephalographic activity (EEG), the Bispectral Index shows an abnormal fluctuation caused by repeated abrupt alterations between normal EEG and abnormal epileptiform EEG patterns.

This article has been cited by other articles:

				N. Ohshima, M. Chinzei, K. Mizuno, M. Hayashida, T. Kitamura, H. Shibuya, and K. Hanaoka Transient decreases in Bispectral Index without associated changes in the level of consciousness during photic stimulation in an epileptic patient Br. J. Anaesth., January 1, 2007; 98(1): 100 - 104. [Abstract] [Full Text] [PDF]