JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Horiuchi, T.
Right arrow Articles by Furuya, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Horiuchi, T.
Right arrow Articles by Furuya, H.
Related Collections
Right arrow Neuroanesthesia
Right arrow Critical Care
Right arrow Trauma

Anesth Analg 2004;99:235-240
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000130389.77859.1C


NEUROSURGICAL ANESTHESIA

The Effects of the {delta}-Opioid Agonist SNC80 on Hind-Limb Motor Function and Neuronal Injury After Spinal Cord Ischemia in Rats

Toshinori Horiuchi, MD*, Masahiko Kawaguchi, MD*, Takanori Sakamoto, MD*, Naoko Kurita, MD*, Satoki Inoue, MD*, Mitsutoshi Nakamura, MD{dagger}, Noboru Konishi, MD{dagger}, and Hitoshi Furuya, MD*

Departments of *Anesthesiology and {dagger}Pathology, Nara Medical University, Nara, Japan

Address correspondence and reprint requests to Masahiko Kawaguchi, MD, Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan. Address e-mail to drjkawa{at}naramed-u.ac.jp

Recent investigation suggested neuroprotective efficacy of a {delta}-opioid agonist in the brain. We investigated the effects of intrathecal treatment with a {delta}-opioid agonist (SNC80) on spinal cord ischemia (SCI) in rats. SCI was induced with an intraaortic balloon catheter. The animals were randomly allocated to one of the following five groups: 1) SNC80 before 9 min of SCI (SNC-9; n = 12), 2) vehicle before 9 min of SCI (V-9; n = 12), 3) SNC80 before 11 min of SCI (SNC-11; n = 10), 4) vehicle before 11 min of SCI (V-11; n = 12), or 5) sham (n = 12). SNC80 (400 nmol) or vehicle was administered 15 min before SCI. Forty-eight hours after reperfusion, hind-limb motor function was assessed by using the Basso, Beattie, Bresnahan (BBB) scale (0 = paraplegia; 21 = normal) and histological assessment of the L4 and L5 spinal segments was performed. BBB scores in the SNC-9 group were higher compared with those in the V-9 group (P < 0.05), whereas there were no differences in BBB scores between the SNC-11 and V-11 groups. There were significantly more normal neurons in the SNC-9 and SNC-11 groups than in the V-9 and V-11 groups (P < 0.05). The results indicate that intrathecal treatment with the {delta}-opioid agonist SNC80 can attenuate hind-limb motor dysfunction and neuronal injury after SCI in rats.

IMPLICATIONS: Although recent evidence suggested neuroprotective efficacy of a {delta}-opioid agonist in the brain, there have been no data regarding its efficacy in the spinal cord. The results in this study showed that the {delta}-opioid agonist SNC80 attenuated neuronal injury after spinal cord ischemia in rats.




This article has been cited by other articles:


Home page
Br J AnaesthHome page
M. Iwata, S. Inoue, M. Kawaguchi, M. Nakamura, N. Konishi, and H. Furuya
Effects of delta-opioid receptor stimulation and inhibition on hippocampal survival in a rat model of forebrain ischaemia
Br. J. Anaesth., October 1, 2007; 99(4): 538 - 546.
[Abstract] [Full Text] [PDF]


Home page
Behav Cogn Neurosci RevHome page
J. W. Grau, E. D. Crown, A. R. Ferguson, S. N. Washburn, M. A. Hook, and R. C. Miranda
Instrumental learning within the spinal cord: underlying mechanisms and implications for recovery after injury.
Behav Cogn Neurosci Rev, December 1, 2006; 5(4): 191 - 239.
[Abstract] [PDF]




Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2004 by the International Anesthesia Research Society.