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NEUROSURGICAL ANESTHESIA

The Effects of the -Opioid Agonist SNC80 on Hind-Limb Motor Function and Neuronal Injury After Spinal Cord Ischemia in Rats

Toshinori Horiuchi, MD^*, Masahiko Kawaguchi, MD^*, Takanori Sakamoto, MD^*, Naoko Kurita, MD^*, Satoki Inoue, MD^*, Mitsutoshi Nakamura, MD, Noboru Konishi, MD, and Hitoshi Furuya, MD^*

Departments of *Anesthesiology and Pathology, Nara Medical University, Nara, Japan

Address correspondence and reprint requests to Masahiko Kawaguchi, MD, Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan. Address e-mail to drjkawa{at}naramed-u.ac.jp

Recent investigation suggested neuroprotective efficacy of a -opioid agonist in the brain. We investigated the effects of intrathecal treatment with a -opioid agonist (SNC80) on spinal cord ischemia (SCI) in rats. SCI was induced with an intraaortic balloon catheter. The animals were randomly allocated to one of the following five groups: 1) SNC80 before 9 min of SCI (SNC-9; n = 12), 2) vehicle before 9 min of SCI (V-9; n = 12), 3) SNC80 before 11 min of SCI (SNC-11; n = 10), 4) vehicle before 11 min of SCI (V-11; n = 12), or 5) sham (n = 12). SNC80 (400 nmol) or vehicle was administered 15 min before SCI. Forty-eight hours after reperfusion, hind-limb motor function was assessed by using the Basso, Beattie, Bresnahan (BBB) scale (0 = paraplegia; 21 = normal) and histological assessment of the L4 and L5 spinal segments was performed. BBB scores in the SNC-9 group were higher compared with those in the V-9 group (P < 0.05), whereas there were no differences in BBB scores between the SNC-11 and V-11 groups. There were significantly more normal neurons in the SNC-9 and SNC-11 groups than in the V-9 and V-11 groups (P < 0.05). The results indicate that intrathecal treatment with the -opioid agonist SNC80 can attenuate hind-limb motor dysfunction and neuronal injury after SCI in rats.

IMPLICATIONS: Although recent evidence suggested neuroprotective efficacy of a -opioid agonist in the brain, there have been no data regarding its efficacy in the spinal cord. The results in this study showed that the -opioid agonist SNC80 attenuated neuronal injury after spinal cord ischemia in rats.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999