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Anesth Analg 2004;99:370-372
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000124681.51487.AD

PEDIATRIC ANESTHESIA

Hepatitis After Sevoflurane Exposure in an Infant Suffering from Primary Hyperoxaluria Type 1

Alexander Reich, MD DEAA*, Anne Schulze Everding, MD{dagger}, Monika Bulla, MD PhD{dagger}, Olaf Anselm Brinkmann, MD{ddagger}, and Hugo Van Aken, MD PhD, FRCA, FANZCA*

Departements of *Anaesthesia and Intensive Care, {dagger}Pediatric Nephrology, and {ddagger}Urology, University Hospital Münster, Münster, Germany

Address correspondence and reprint requests to Alexander Reich, MD, DEAA, Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Münster, Albert Schweitzer-Str. 33, D-48129 Münster, Germany. Address e-mail to reich{at}anit.uni-muenster.de

An 11-mo-old child with primary hyperoxaluria was scheduled for a nephroureteromia procedure. Anesthesia was induced and maintained with sevoflurane. Two days after the operation, a hepatomegaly was diagnosed, and a considerable increase in liver enzymes was observed. These pathologic findings disappeared without treatment within 7 days. In a subsequent operation 2 wk later, general anesthesia was performed (sevoflurane was avoided). After the second operation, no pathologic findings could be detected. Nothing in this patient’s disease or the conduct of the anesthesia suggested a cause for the injury other than an idiosyncratic response to sevoflurane.

IMPLICATIONS: Sevoflurane is a frequently used inhaled anesthetic in pediatric anesthesia and is regarded as a drug with low organ toxicity. This case report demonstrates a possible connection of the use of this drug and hepatic injury.




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E. Turillazzi, S. D'Errico, M. Neri, I. Riezzo, and V. Fineschi
A Fatal Case of Fulminant Hepatic Necrosis Following Sevoflurane Anesthesia
Toxicol Pathol, October 1, 2007; 35(6): 780 - 785.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2004 by the International Anesthesia Research Society.