JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Minogue, S. C. Articles by Lampa, M. J. Search for Related Content PubMed PubMed Citation Articles by Minogue, S. C. Articles by Lampa, M. J. Related Collections Airway Pharmacology

---

GENERAL ARTICLES

Laryngotracheal Topicalization with Lidocaine Before Intubation Decreases the Incidence of Coughing on Emergence from General Anesthesia

From the Department of Anesthesia, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada

Address correspondence and reprint requests to Sean Minogue, FCARCSI, Department of Anaesthesia, The Adelaide and Meath Hospital Dublin incorporating the National Children’s Hospital, Tallaght, Dublin 24, Ireland. Address email to minogues{at}indigo.ie

Coughing on emergence can result in a number of undesirable side effects, including hypertension, tachycardia, tachyarrhythmias, increased intracranial pressure, and increased intraocular pressure. The efficacy of endotracheal spraying with lidocaine at the time of intubation in preventing coughing on emergence is unknown. In a double-blind placebo-controlled study, we randomized 50 ASA physical status I and II patients presenting for elective gynecological surgery <2 h duration to receive either endotracheal lidocaine 160 mg or placebo before intubation. Both groups were comparable in terms of demographics and intraoperative conditions. The incidence of coughing before tracheal extubation was less frequent in the lidocaine group (26%) than in the placebo group (66%, P < 0.01), as was the incidence after tracheal extubation (4% versus 30%, P = 0.022). This study supports the use of endotracheal lidocaine before intubation in patients undergoing general anesthesia for surgery <2 h duration where coughing on emergence is undesirable.

IMPLICATIONS: We studied the effect of laryngotracheal spraying with lidocaine before intubation on the incidence of coughing on emergence from general anesthesia in cases <2 h duration and found its use to be associated with a significantly decreased incidence of coughing on emergence.

This article has been cited by other articles:

				P. Hans, H. Marechal, and V. Bonhomme Effect of propofol and sevoflurane on coughing in smokers and non-smokers awakening from general anaesthesia at the end of a cervical spine surgery Br. J. Anaesth., November 1, 2008; 101(5): 731 - 737. [Abstract] [Full Text] [PDF]

				M. Hohlrieder, W. Tiefenthaler, H. Klaus, M. Gabl, P. Kavakebi, C. Keller, and A. Benzer Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia Br. J. Anaesth., October 1, 2007; 99(4): 587 - 591. [Abstract] [Full Text] [PDF]

				J.-P. Estebe, M. Gentili, P. Le Corre, G. Dollo, F. Chevanne, and C. Ecoffey Alkalinization of Intracuff Lidocaine: Efficacy and Safety Anesth. Analg., November 1, 2005; 101(5): 1536 - 1541. [Abstract] [Full Text] [PDF]

				Topical Tracheal Lidocaine Improves Endotracheal Tube Tolerance Journal Watch Emergency Medicine, December 15, 2004; 2004(1215): 6 - 6. [Full Text]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999