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Anesth Analg 2004;99:1258-1260
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000131726.09685.BF

GENERAL ARTICLES

A Patient with Glanzmann’s Thrombasthenia for Emergent Abdominal Surgery

Halil Ibrahim Uzunlar, MD, Ahmet Eroglu, MD, Ahmet Can Senel, MD, Habib Bostan, MD, and Nesrin Erciyes, MD

Department of Anesthesiology and Reanimation, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey

Address correspondence and reprint requests to Halil Ibrahim Uzunlar, MD, Karadeniz Technical University Tip Fakültesi, Anesteziyoloji 61080, Trabzon, Turkey. Address e-mail to uzunlar{at}gmx.com.tr

Glanzmann’s thrombasthenia is a rare autosomal recessive disease characterized by potentially major mucocutaneous complications and nose bleeds. It is considered hazardous for these surgical patients to conceive, with a high risk of urgent surgery. The treatment of bleeding or prevention of hemorrhage for surgery or invasive procedures is based on platelet transfusion. However, platelet transfusions may be responsible for the development of alloimmunization, with a high risk of future platelet refractoriness. We report a surgical case of Glanzmann’s thrombasthenia complicated by nasopharyngeal bleeding and managed with platelet transfusions, recombinant activated factor VII, and postoperative airway management in the intensive care unit.

IMPLICATIONS: We describe the management of an emergent surgical patient with Glanzmann’s thrombasthenia and nasopharyngeal bleeding requiring platelets and recombinant activated factor VII infusions. These patients may need postoperative intensive care.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2004 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2004 by the International Anesthesia Research Society.