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Anesth Analg 2004;99:1528-1531
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000133915.56613.D9

NEUROSURGICAL ANESTHESIA

Intrathecal Morphine, but Not Buprenorphine or Pentazocine, Can Induce Spastic Paraparesis After a Noninjurious Interval of Spinal Cord Ischemia in the Rat

Seiya Nakamura, MD PhD, Manabu Kakinohana, MD PhD, Kazuhiro Sugahara, MD PhD, Sakura Kinjo, MD, and Yuji Miyata, MD

Department of Anesthesiology, University of the Ryukyus, Okinawa, Japan

Address correspondence and reprint requests to Manabu Kakinohana, MD, PhD, Department of Anesthesiology, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903–0215, Japan. Address e-mail to mnb-shk{at}ryukyu.ne.jp

In this study, we sought to determine the effect of intrathecal (IT) pentazocine or buprenorphine on the neurological outcome after a short interval of spinal cord ischemia in rats. Although IT morphine (30 µg) induced spastic paraparesis after 6 min of aortic occlusion, neither pentazocine (150 µg) nor buprenorphine (4 µg) produced neurological dysfunction. Our results indicate that the effect of various opioids on the motor function after a noninjurious interval of spinal cord ischemia is opioid-specific.

IMPLICATION: The present study shows that neither intrathecal pentazocine nor intrathecal buprenorphine can increase spasticity of hindlimbs after a noninjurious interval of spinal cord ischemia in rats. These results indicate that the effect of various opioids on motor function after a noninjurious interval of spinal cord ischemia might be opioid-specific.




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M. Kakinohana, S. Nakamura, T. Fuchigami, K. J. Davison, M. Marsala, and K. Sugahara
Mu and delta, but not kappa, opioid agonists induce spastic paraparesis after a short period of spinal cord ischaemia in rats
Br. J. Anaesth., January 1, 2006; 96(1): 88 - 94.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2004 by the International Anesthesia Research Society.