JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by James, M. F.
Right arrow Articles by Ellis, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by James, M. F.
Right arrow Articles by Ellis, P.
Related Collections
Right arrow Blood
Right arrow Monitoring (Non-cardiac)

Anesth Analg 2004;99:1593-1597
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000136477.46472.EB

CARDIOVASCULAR ANESTHESIA

The Effect of Hemopure® on Coagulation in Clinically Relevant Concentrations

Michael F. James, PhD, FRCA, Helét E. Potgieter, FCA(SA), and P. Ellis, Dip Med Tech

Department of Anaesthesia, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa

Address correspondence to Michael F. James, PhD, FRCA, Department of Anaesthesia, Groote Schuur Hospital, 7925 Observatory, Cape Town, South Africa. Address e-mail to james{at}cormack.uct.ac.za Reprints will not be available from the authors.

Hemopure® is a new colloidal blood substitute that may influence coagulation. We designed this study to examine the influence of this product on in vitro coagulation of whole blood by using the thrombelastograph® (TEG®). Blood samples from 20 volunteers were obtained. Hemopure® was added to blood samples to obtain 0.5, 1, and 2 g/dL mixtures of Hemopure® in blood. Control consisted of an undiluted sample and, for comparison, two samples diluted with volumes of lactated Ringer’s solution (LR) equivalent to the two higher Hemopure® dilutions. TEG® with Hemopure® at a concentration of 2 g/dL showed significantly shorter reaction and clot formation k times and an increased {alpha} angle compared with control. LR dilution with equivalent volume to 2 g/dL Hemopure® solution also resulted in significantly shorter reaction and k times, as well as an increased {alpha} angle. Coagulation in samples with Hemopure® at concentrations of 0.5 and 1 mg/dL did not vary significantly from control. Maximum amplitude did not vary significantly from control in any samples. The effect of Hemopure® on TEG® measures of coagulation is not significantly different from that of LR at clinically relevant concentrations.

IMPLICATIONS: Hemopure®, a polymerized bovine hemoglobin used as a blood substitute, might interfere with coagulation. At clinically relevant in vitro dilutions of whole blood, the effects of Hemopure® on whole-blood coagulation as measured by the thrombelastograph were not significantly different from those of the carrier substance, lactated Ringer’s solution.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2004 by the International Anesthesia Research Society.