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Anesth Analg 2004;99:1696-1698
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000136967.82197.82

ANESTHETIC PHARMACOLOGY

Intravenous Lidocaine Suppresses Fentanyl-Induced Coughing: A Double-Blind, Prospective, Randomized Placebo-Controlled Study

Chandra K. Pandey, MD, Mehdi Raza, MD, Rajeev Ranjan, MD, Archana Lakra, MD, Anil Agarwal, MD, Uttam Singh, PhD, R. B. Singh, MD, PDCC, and Prabhat K. Singh, MD

Department of Anaesthesiology and Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

Address correspondence to Chandra Kant Pandey, MD, Department of Anaesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India. Address e-mail to ckpandey{at}sgpgi.ac.in

IV lidocaine is effective in suppressing the cough reflex of tracheal intubation, extubation, bronchography, bronchoscopy, and laryngoscopy. We investigated this effect of lidocaine on fentanyl-induced cough in 502 patients of ASA physical status I and II scheduled for elective surgery. The patients were assigned to 2 equal groups to receive either lidocaine 1.5 mg/kg or placebo (0.9% saline) over 5 s 1 min before the administration of fentanyl 3 µg/kg in a randomized and double-blind fashion. Coughs were classified as coughing and graded as mild (1–2), moderate (3–4), or severe (5 or more). The results of the study suggest that IV lidocaine 1.5 mg/kg, when administered 1 min before fentanyl, is significantly effective in suppressing fentanyl-induced cough compared to placebo (0.9% saline) (218 versus 165 patients) (P < 0.002) but without affecting the severity of cough (P > 0.05).

IMPLICATIONS: Fentanyl administration elicits cough. IV lidocaine 1.5 mg/kg suppresses fentanyl-induced coughing.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2004 by the International Anesthesia Research Society.