JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Saeki, H.
Right arrow Articles by Sakabe, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saeki, H.
Right arrow Articles by Sakabe, T.
Related Collections
Right arrow Critical Care
Right arrow Trauma
Right arrow Neuroanesthesia

Anesth Analg 2004;99:1805-1812
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000138039.04548.3D

NEUROSURGICAL ANESTHESIA

Is Intrathecal Magnesium Sulfate Safe and Protective Against Ischemic Spinal Cord Injury in Rabbits?

Hiroshi Saeki, MD, Mishiya Matsumoto, MD, Shuichi Kaneko, MD, Shunsuke Tsuruta, MD, Ying Jun Cui, MD, Kazunobu Ohtake, MD, Kazuyoshi Ishida, MD, and Takefumi Sakabe, MD

Department of Anesthesiology-Resuscitology, Yamaguchi University School of Medicine, Japan

Address correspondence and reprint requests to Mishiya Matsumoto, MD, Department of Anesthesiology-Resuscitology, Yamaguchi University School of Medicine, 1–1–1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan. Address e-mail to mishiya{at}yamaguchi-u.ac.jp

We performed three sets of experiments to investigate the safety of intrathecal magnesium and to determine its optimal dose for protection, if any, against ischemic spinal cord injury in rabbits. First, we examined neurotoxicity of 0.3, 1, 2, or 3 mg/kg of magnesium sulfate (n = 6 each). Significant sensory dysfunction was observed in the 3-mg/kg group 7 days after administration. Motor dysfunction was found in two rabbits in both the 2- and 3-mg/kg groups. The area of destruction in laminae V-VII was observed in one, two, and one rabbit in the 1-, 2-, and 3-mg/kg groups, respectively. Second, we investigated the temporal profile (6 h, 48 h, and 96 h [n = 3 each]) of histopathologic changes after 3 mg/kg of magnesium sulfate and confirmed similar changes in the rabbits with motor dysfunction at 48 and 96 h. Third, we evaluated the effects of 0.3 mg/kg or 1 mg/kg of magnesium sulfate or saline (n = 6 each) administered before ischemia on hindlimb motor function and histopathology after spinal cord ischemia (15 min). Magnesium did not improve neurologic or histopathologic outcome 96 h after reperfusion. The results indicate that intrathecal magnesium has a risk of neurotoxicity and shows no evidence of protective effects against ischemic spinal cord injury.

IMPLICATIONS: Intrathecal administration of magnesium sulfate has a risk of neurotoxicity and shows no evidence of protective effects against ischemic spinal cord injury. Although the intrathecal use of magnesium sulfate has been reported in humans, further evaluations of its safety are warranted.




This article has been cited by other articles:


Home page
 Br J AnaesthHome page
A. Bilir, S. Gulec, A. Erkan, and A. Ozcelik
Epidural magnesium reduces postoperative analgesic requirement
Br. J. Anaesth., April 1, 2007; 98(4): 519 - 523.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2004 by the International Anesthesia Research Society.