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GENERAL ARTICLES

Hypertensive Crisis in a Patient Undergoing Percutaneous Radiofrequency Ablation of an Adrenal Mass Under General Anesthesia

Eduardo N. Chini, MD, PhD^*, Michael J. Brown, MD^*, Michael A. Farrell, MD, and J. William Charboneau, MD

Departments of *Anesthesiology and Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota

Address correspondence and reprint requests to Eduardo N. Chini, MD, PhD, Department of Anesthesiology, Mayo Clinic, 200 First St. S.W., Rochester, MN 55905. Address e-mail to Chini.eduardo{at}mayo.edu

Radiofrequency ablation (RFA) is an effective therapeutic intervention for a variety of neoplastic lesions. Many of these procedures are conducted with patients under general anesthesia. Although RFA is associated with infrequent complications, it is not without risk. Injury to adjacent normal structures is a major concern during RFA of cancerous lesions. Unintended injury to normal adrenal tissue during RFA of adrenal tumors can lead to hypertensive crisis, a potentially catastrophic complication. Hemodynamic consequences of RFA of primary or metastatic adrenal masses have not been reported. We report a case of hypertensive crisis (249/140 mm Hg), tachycardia, and ventricular arrhythmia in an 82-yr-old woman undergoing RFA of renal cell carcinoma metastatic to the adrenal gland. Anesthesiologists should be aware of this potentially catastrophic complication. Direct-acting vasodilators and short-acting ß₁-adrenergic antagonists should be immediately available, and intraarterial blood pressure monitoring should be seriously considered when providing care for patients undergoing RFA of an adrenal mass.

IMPLICATIONS: Anesthesiologists are often asked to provide care for patients undergoing radiofrequency ablation of neoplastic lesions. It is important that they be aware of and be prepared to treat complications such as severe hypertension, tachycardia, and arrhythmias, which can occur during these procedures.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999