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Anesth Analg 2009;0:ane.0b013e3181acc6fc
© 2009 International Anesthesia Research Society
doi: 10.1213/ane.0b013e3181acc6fc

brief-report

The Efficacy and Safety of Continuous Intravenous Administration of Remifentanil for Birth Pain Relief: An Open Study of 205 Parturients

Paola D'Onofrio, MD, Anna Maria Melani Novelli, MD, Federico Mecacci, MD, and Gianfranco Scarselli, MD

From the Dipartimento Materno-Infantile, Azienda Ospedaliera Universitaria Careggi, Firenze, Italia.

Address correspondence to Paola d'Onofrio, MD, S.O.D. Anestesia DAI Materno-Infantile, A.O.U. Careggi, Viale Pieraccini 17, Firenze, Italia. Address e-mail to paodono{at}libero.it.

Abstract

In an observational study, we prospectively evaluated the efficacy and safety of remifentanil in 205 parturients. Remifentanil was administered as a continuous infusion. The initial infusion of 0.025 µg · kg–1 · min–1 was increased in a stepwise manner to a maximum dose of 0.15 µg · kg–1 · min–1. Maternal pain, other maternal and fetal variables, side effects, and satisfaction were recorded. The mean (±SD) visual analog score before the start of the infusion was 9.4 ± 1.2 cm and decreased to 5.1 ± 0.4 cm after 5 min and 3.6 ± 1.5 cm after 30 min. The maternal side effects were minimal and no fetal or neonatal side effects were noted.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2009 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2009 by the International Anesthesia Research Society.