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Anesth Analg 2005;100:1867
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000156675.24364.54

LETTER TO THE EDITOR

The Splenectomized Dog: Do We Have to Say Farewell to an Established Hemorrhagic Shock Model?

José Reinaldo Cerqueira Braz, MD, PhD, and Leandro Gobbo Braz, MD

Department of Anesthesiology, UNESP School of Medicine, Botucatu, São Paulo, Brazil, anestesi{at}fmb.unesp.br

In Response:

We agree with Kemming et al.’s comments on Mycoplasma haemocanis and its effects on red cells in dogs. However, according to information from our University’s Center for the Control of Infections Diseases in Animals, the prevalence of M. haemocanis in kennel-raised dogs supplied to research laboratories in Botucatu, São Paulo, Brazil is very low. In addition, the dogs used in our study (1) were considered healthy after clinical examination and normal erythrocyte count—see the Methods section of our article. In addition, our study was carried out in acutely splenectomized dogs. As M. haemocanis is a red cell parasite that causes disease mainly in immunosuppressed or previously splenectomized dogs, we are confident that its influence was not underestimated in our study.

Reference

  1. Braz JRC, do Nascimento P Jr, Paiva Filho O et al. The systemic and gastrointestinal oxygenation effects of hemorrhage shock resuscitation with hypertonic saline and hypertonic saline 6% dextran-70: a comparative study in dogs. Anesth Analg 2004;99:536–46.[Abstract/Free Full Text]




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press