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LETTER TO THE EDITOR

Short-Lasting Effect of Perineural Resiniferatoxin on Mechanical Hyperalgesia

Department of Anesthesia; University of Iowa Hospitals and Clinics; Iowa City, IA; ratan-banik{at}uiowa.edu

To the Editor:

I have read with great interest the report by Kissin et al. (1). Intrathecal administration of small-dose (100 ng) resiniferatoxin does not influence responses to mechanical stimuli as evaluated by von Frey hair stimulation (2). Responses to von Frey hair stimulation are considered as light touch response. The current article did not disagree with the above finding but opined that greater concentrations of resiniferatoxin prevented responses to noxious mechanical stimuli. It is very interesting that the duration of the effect of resiniferatoxin on noxious mechanosensitivity is much shorter (<48 h) than that of noxious heat sensitivity (>3 wk).

It is difficult to understand why the authors did not use any vehicle control in showing dose dependency of resiniferatoxin in Figures 1 and 2. Because they dissolved resiniferatoxin in dimethyl sulfoxide and Tween 80, it may be necessary to know if these substances have any effect on animal behaviors. The first sentence in the Results section was "Resiniferatoxin-induced hyperalgesia was dose dependent." However, the authors, in fact, discussed resiniferatoxin-induced hypoalgesia but not hyperalgesia in the text and in Figures 1 and 2, although this could be a printing error. In the fourth paragraph of Results, the authors stated, "Perineural resiniferatoxin prevented mechanical incision-induced hyperalgesia." The correct sentence may be "Perineural resiniferatoxin prevented incision-induced mechanical hyperalgesia".

References

1. Kissin I, Davison N, Bradley EL Jr. Perineural resiniferatoxin prevents hyperalgesia in a rat model of postoperative pain. Anesth Analg 2005;100:774–80.[Abstract/Free Full Text]
2. Karai L, Brown DC, Mannes AJ, et al. Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control. J Clin Invest 2004;113:1344–52.[Web of Science][Medline]

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