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Anesth Analg 2006;102:647
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000190742.82769.7C


LETTER TO THE EDITOR

Routine Inhaled Induction in Adults: A Safe Practice?

Anton A. van den Berg, and Abdelaly Abeidi

Department of Anaesthetics, Mayo General Hospital, Castlebar, County Mayo, Ireland

In Response:

Although we respect Smith and Elliott’s comments, as adult and pediatric anesthesiologists we agree with the Central Consultants and Specialists Committee of the British Medical Association that generalist anesthesiologists require greater training (1), thereby acquiring broader experience, than specialist anesthesiologists, and we believe that anesthetic practices should be rationalized by investigation (2,3) rather than essentially unreferenced opinion.

We agree that no studies compare safety of IV versus inhaled induction in adults or children and consider them warranted. As regards a 90-kg excited adult, of our 5500 patients offered sevoflurane since 2000 (4) only one male soldier removed the mask and requested IV induction; none developed airway problems or regurgitated. This overall satisfactory experience is shared by others (5).

Regarding methods of minimizing cannulation discomfort, audits comparing these with inhaled induction on the induction satisfaction of needle phobic patients are required. Although we minimize (6,7) or avoid cannulation pain and use eutectic mixture of local anesthetics in adults (8), all methods have nursing, cost, and administrative constraints. Furthermore, routine cannulation in day surgery units is not universal and, where practiced, is often causes morbidity and needle-phobia because various trainees frequently cannulate unpremedicated patients without cutaneous analgesia.

The popularity of midazolam IV for anxiolysis when bringing patients to the operating room (9) is unresearched and neglects anxiety before transportation in 50% of adults who desire earlier oral premedication (10). Although the considerations promoting ambulatory surgery have resulted in patients not receiving nocturnal or timely preoperative anxiolysis, satisfactory sedation follows midazolam (11,12) or temazepam (13,14), 0.25 to 0.5 mg/kg per os administered per nursing protocol on patient arrival in the day surgery unit.

Regarding halothane toxicity (15) and sevoflurane safety, halothane vaporizers have been removed from anesthetic machines in many countries. We endorse this and consider halothane an historical anesthetic.

Neuroexcitation after sevoflurane is not described in adults. Of greater concern in anesthesia are various propofol (di-isopropyl-phenol) induced iatrogenic morbidities that prohibit propofol’s use in children <3 yr and pregnancy (16). Invariable pain on injection, hypotension and rare neuroexcitatory phenomena demonstrate the peripheral and central neurotoxicities of phenols (17,18).

We strongly believe that patient satisfaction is optimized when patient preferences are canvassed and encourage "patient-centered anesthesia" (where appropriate patient opinion is implemented) rather than "practitioner-centered anesthesia" (where anaesthesiologist preference irrespectively prevails). In this respect, our "sister" audit of children’s induction route choice and opinionable age may interest Dr. Smith. We found that children >2 yr occasionally and children >5 yr invariably express preferences; approximately 20% choose IV induction (of whom approximately 50% subsequently opt for inhalation), approximately 60% choose inhalation, and approximately 20% are undecided or unable to choose (19). We now also canvass induction opinion of children, in whom cannulation is often difficult (20).

References

  1. Central Consultants and Specialists Committee Secretariat. Central Consultants and Specialists Committee Newsletter S4 2003-04. London: British Medical Association House.
  2. van den Berg AA. Persuasion in clinical practice. A reply- the 3 "R’s." Anaesthesia 1993;4:742.
  3. van den Berg AA. Retrospective soliloquy. Rationalising practice through prospective audit. Anaesthesia 1999;54:599-600.[ISI][Medline]
  4. van den Berg AA. Sevoflurane induction of anaesthesia in adults (SIA): a year’s experience rationalizes ‘needleless’ induction of anaesthesia. Acta Anaesthesiol Scand 2001;115:57.
  5. Muzi M, Robinson BJ, Ebert TJ, O’Brien TJ. Induction of anesthesia and endotracheal intubation with sevoflurane in adults. Anesthesiology 1996;85:536-43.[ISI][Medline]
  6. van den Berg AA, Abeysekera RMMS. Rationalising venepuncture pain: patient factors and pre-cannulation lignocaine injection. Anaesthesia 1993;48:84.[ISI][Medline]
  7. van den Berg AA. Skin sensitivity of the arm. Comparison of dorsum of arm, dorsum of hand, cephalic, ventrum of arm and cubital fossa. Anaesthesia 1996;5:194-7.
  8. van den Berg AA, Honjol NM, Prabhu R et al. Clinical comparison of buprenorphine, diclofenac, fentanyl, nalbuphine, morphine and pethidine for ENT (and eye) surgery: intraoperative, recovery and postoperative effects. Br J Clinical Pharm 1994;38:533-44.
  9. Bauer KP, Dom PM, Ramirez AM, O’Flaherty JE. Preoperative intravenous midazolam: benefits beyond anxiolysis. J Clin Anesth 2004;16:177-83.[ISI][Medline]
  10. van den Berg AA. The wishes of American adults regarding pre-anesthetic medication ("premedication") in day surgery units: a guide to practice. American Society of Anesthesiologists Abstracts, Annual Meeting, San Francisco, California, October 2003. Abstract A-2.
  11. Abdul-Latif MS, Putland AJ, McCluskey A, et al. Oral midazolam premedication for day case breast surgery: a randomised prospective double-blind placebo-controlled study. Anaesthesia 2001;56:990-4.[ISI][Medline]
  12. Brisius KK, Bannister CF. Oral midazolam premedication in preadolescents and adolescents. Anesth Analg 2002;94:31-6.[Abstract/Free Full Text]
  13. Bailie R, Christmas L, Price N et al. Effects of temazepam premedication on cognitive recovery following alfentanil-propofol anaesthesia. Br J Anaesth 1989;63:68-75.[Abstract/Free Full Text]
  14. Howell SJ, Wanigasekera V, Young J, et al. Effects of propofol and thiopentone, and benzodiazepine premedication on heart rate variability measured by spectral analysis. Br J Anaesth 1995;74:168-73.[Abstract/Free Full Text]
  15. van den Berg AA, Honjol NM, Rozario CJ, Mphanza T. Headache and vomiting after halothane, isoflurane and enflurane anaesthesia: an analysis of outcome after ear, nose, throat and eye surgery. Acta Anaesthesiol Scand 1998;42:658-63.[ISI][Medline]
  16. Diprivan 1% (propofol). Patient information leaflet. AstraZeneca UK Limited, Luton, Bedfordshire, United Kingdom. Leaflet PO11555.
  17. Islander G, Vinge E. Severe neuroexcitatory symptoms after anaesthesia—with focus on propofol anaesrthesia. Acta Anaesthesiol Scand 2000;44:144-9.[ISI][Medline]
  18. van den Berg AA, Neuvonen P, Ezz M. Neuro-excitatory effects after propofol: a phenol-related neurotoxic effect? Acta Anaesthesiol Scand 2001;45:988.
  19. van den Berg AA, Muir J. An audit of pediatric patient choice of route for induction of anesthesia: 19% choose an intravenous induction! American Society of Anesthesiologists Abstracts, Annual Meeting, 2005, New Orleans, Louisiana, October 2005. In press.
  20. Donati F, Guay J. No substitute for the intravenous route. Anesthesiology 2001;94:1-2.[ISI][Medline]




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press