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Anesth Analg 2006;103:1331-1332
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000242359.70291.c3

LETTER TO THE EDITOR

Editor-in-Chief Steven L. Shafer

Preemptive Analgesia by Nonsteroidal Antiinflammatory Drugs

Yushi U. Adachi, MD, PhD, Hideki Sano, MD, Matsuyuki Doi, MD, PhD, and Shigehito Sato, MD, PhD

Intensive Care Unit of University Hospital; Hamamatsu University School of Medicine; Hamamatsu, Japan; yuadachi{at}poppy.ocn.ne.jp

To the Editor:

Gramke et al. (1) demonstrated preemptive analgesia from sublingually administered piroxicam, a nonsteroidal antiinflammatory drug (NSAID). In their discussion the authors referred to a previous investigation by O’Hanlon et al. (2) that also demonstrated preemptive analgesia. Other NSAIDs, including IV ketorolac (3) and flurbiprofen (4,5) have also been reported to provide preemptive analgesia. In our study (5) we confirmed that preemptive and long-lasting analgesia from flurbiprofen was independent of residual drug concentration (5).

The characteristics of preemptive analgesia have been reviewed by Kelly et al. (6). Available data suggest anesthesiologists should apply multimodal analgesic techniques, including NSAIDS, to achieve the benefits of preemptive analgesia.

REFERENCES

  1. Gramke HF, Petry JJ, Durieux ME, et al. Sublingual piroxicam for postoperative analgesia: preoperative versus postoperative administration. A randomized, double-blind study. Anesth Analg 2006;102:755–8.[Abstract/Free Full Text]
  2. O’Hanlon DM, Thambipillai T, Colbert ST. Timing of preemptive tenoxicam is important for postoperative analgesia. Can J Anaesth 2001;48:162–6.[Web of Science][Medline]
  3. Norman PH, Daley MD, Lindsey RW. Preemptive analgesic effects of ketrolac in ankle fracture surgery. Anesthesiology 2001;84:599–603.
  4. Nakayama M, Ichinose H, Yamamoto S, et al. Perioperative intravenous flurbiprofen reduces postoperative pain after abdominal hysterectomy. Can J Anaesth 2001;48:234–7.[Web of Science][Medline]
  5. Aoki H, Satomoto M, Yamada S, et al. The effectiveness of perioperative intravenous flurbiprofen in minor ear, neck and nose surgery. Masui 2002;51:857–61 (Japanese).
  6. Kelly DJ, Ahmad M, Brull SJ. Preemptive analgesia II: recent advances and current trends. Can J Anaesth 2001;48:1091–101.[Web of Science][Medline]




This Article
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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press