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Anesth Analg 2007;104:219-220
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000251916.92662.57

LETTER TO THE EDITOR

Editor-in-Chief Steven L. Shafer

Does the N-Methyl-d-Aspartate Receptor Contribute to the Effects of Isoflurane, Sevoflurane, and Ethanol?

Yuki Sato, MD, PhD, Norimasa Seo, MD, PhD, and Eiji Kobayashi, MD, PhD

Department of Anesthesiology, aneyuki{at}jichi.ac.jp (Sato, Seo) Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan (Kobayashi)

To the Editor:

Eger et al. (1) and Solt et al. (2) recently documented the role of N-methyl-d-aspartate (NMDA) receptor producing immobilization in response to inhaled anesthetics. They concluded that NMDA does not mediate immobility caused by inhaled anesthetics. This is consistent with our findings in NMDA receptor {varepsilon}1 subunit knockout mice, which did not affect sensitivity to isoflurane and sevoflurane as assessed by loss of the righting reflex (3,4). Because ethanol and volatile anesthetics depress currents evoked by glutamate application by actions independent of {gamma}-amino butyric acid (GABA)A and glycine receptors in the spinal cord (1), do NMDA receptor blockers, such as dizocilpine [MK-801] and (R)-4-(3-phosphonopropyl) piperazine-2-carboxylic acid [CPP], decrease the MAC of ethanol in their experimental conditions?

REFERENCES

  1. Eger EI II, Liao M, Laster MJ, et al. Contrasting roles of the N-methyl-d-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics. Anesth Analg 2006;102:1397–406.[Abstract/Free Full Text]
  2. Solt K, Eger EI II, Raines DE. Differential modulation of human N-methyl-d-aspartate receptors by structurally diverse general anesthetics. Anesth Analg 2006;102:1407–11.[Abstract/Free Full Text]
  3. Sato Y, Kobayashi E, Murayama T, et al. Effect of N-methyl-d-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology 2005;102:557–61.[ISI][Medline]
  4. Sato Y, Seo N, Kobayashi E. Ethanol-induced hypnotic tolerance is absent in N-methyl-d-aspartate receptor epsilon1 subunit knockout mice. Anesth Analg 2006;103:117–20.[Abstract/Free Full Text]




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press