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LETTER TO THE EDITOR

Does the N-Methyl-d-Aspartate Receptor Contribute to the Effects of Isoflurane, Sevoflurane, and Ethanol?

Department of Anesthesia and Perioperative Care, University of California, San Francisco, egere{at}anesthesia.ucsf.edu

In Response:

We are pleased that using a different approach, Sato et al. (1,2) reached a conclusion parallel to the one we arrived at for conventional inhaled anesthetics (3,4). We agree that such anesthetics do not produce anesthesia (in our case, as defined by immobility) by an action on NMDA receptors. We have not studied the effect of MK-801 or CPP on the MAC of ethanol, although this might be desirable to complete the parallel with their studies.

REFERENCES

1. Sato Y, Kobayashi E, Murayama T, et al. Effect of N-methyl-d-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology 2005;102:557–61.[Web of Science][Medline]
2. Sato Y, Seo N, Kobayashi E. Ethanol-induced hypnotic tolerance is absent in N-methyl-d-aspartate receptor epsilon1 subunit knockout mice. Anesth Analg 2006;103:117–20.[Abstract/Free Full Text]
3. Eger EI II, Liao M, Laster MJ, et al. Contrasting roles of the N-methyl-d-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics. Anesth Analg 2006;102:1397–406.[Abstract/Free Full Text]
4. Solt K, Eger EI II, Raines DE. Differential modulation of human N-methyl-d-aspartate receptors by structurally diverse general anesthetics. Anesth Analg 2006;102:1407–11.[Abstract/Free Full Text]

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