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Anesth Analg 2007;105:287-288
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000263016.09267.f5

LETTER TO THE EDITOR

Early Termination Penalty

Catherine M. O'Malley, FFARCSI, and Elliott Bennett-Guerrero, MD

Department of Anaesthesia; St James's Hospital; Dublin 8, Ireland; CAOMalley{at}stjames.ie (O'Malley) Duke Clinical Research Institute; Duke University Medical Center; Durham, NC (Bennett-Guerrero)

In Response:

The general thrust of Dr. Wax's (1) comments is laudable, i.e., there is clearly a need for data from well-conducted clinical trials, which can be used to improve care and patient outcome. In theory, we would have liked to continue enrollment in our study (2), however, to optimize care of our patients, it was deemed prudent to stop enrollment.

We take Dr. Wax's comments one step further. We believe that more large multicenter "clinical effectiveness" trials, with broad eligibility criteria, need to be conducted. Only these studies can generate conclusions that can be "generalized" to the broader medical community. A result from a single center study such as ours may be valid for that site, but cannot be strictly generalized to patients at other hospitals.

REFERENCES

  1. Wax D. Early termination penalty. Anesth Analg 2007;104:287.
  2. O'Malley CM, Frumento RJ, Hardy MA, et al. A randomized, double-blind comparison of lactated Ringer's solution and 0.9% NaCl during renal transplantation. Anesth Analg 2005;100:1518–24.[Abstract/Free Full Text]




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2007 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press