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Anesth Analg 2007;105:535-536
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000265665.15722.70

LETTER TO THE EDITOR

Section Editor:
Lawrence Saidman

Does the Choice of QTc Formula Matter?

Yoshihiro Fujiwara, MD, and Toru Komatsu, MD

Department of Anesthesiology; Aichi Medical University School of Medicine; 21 Yazako Nagakute; Aichi, 480-1195 Japan; yyoshiff{at}aichi-med-u.ac.jp

To the Editor:

A recent article by Sen et al. (1) used Bazett’s formula (2) to demonstrate that the QTc interval is prolonged in severe preeclamptic patients. Although most often used for correction of the QT interval, Bazett’s formula may lead to overcorrection at higher heart rates and undercorrection at lower heart rates (3,4). A formula that is more robust in the presence of heart rate changes, such as Fridericia’s formula (5), should have been chosen for this study, in which heart rate considerably decreased after spinal anesthesia.

REFERENCES

  1. Sejn S, Ozmert G, Turan H, Caliskan E, Onbasili A, Kaya D. The effects of spinal anesthesia on QT interval in preeclamptic patients. Anesth Analg 2006;103:1250–5[Abstract/Free Full Text]
  2. Bazett HC. An analysis of the time-relations of electrocardiograms. Heart 1920;7:353–70[Web of Science]
  3. Charbit B, Samain E, Merckx P, Funck-Brentano C. QT interval measurement: evaluation of automatic QTc measurement and new simple method to calculate and interpret corrected QT interval. Anesthesiology 2006;104:255–60[Web of Science][Medline]
  4. Brouwer J, Van Den Berg MP, Grobbee DE, Haaksma J, Wilde AA. Diagnostic performance of various QTc interval formulas in a large family with long QT syndrome type 3: Bazett’s formula not so bad after all... Ann Noninvasive Electrocardiol 2003;8:269–74[Web of Science][Medline]
  5. Fridericia L. Die systolendauer im elektrokardiogramm bei normalen menshen und bei herzkranken. Acta Med Scand 1920;54:469–86




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2007 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press