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Anesth Analg 2007;105:539-540
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000261261.29582.b6

LETTER TO THE EDITOR

Section Editor:
Lawrence Saidman

Ketamine Versus Lidocaine for the Pain of Propofol Injection

Zafer Tabboush, MD

Department of Anesthesiology; Kingdom Hospital; Riyadh, Saudi Arabia; zafer{at}cyberia.net.lb

To the Editor:

Recently, Koo et al. (1) showed that ketamine 0.1 mg/kg administered just before propofol injection can reduce the incidence of propofol- induced pain. In their results, however, they mention that the incidence of pain in patients receiving ketamine 0.1 mg/kg did not differ significantly from that in patients who received 2 mL 2% lidocaine before propofol. This nonsignificant difference allows us to question the benefit from the use of ketamine to prevent propofol pain. The study of Koo et al. fails to change the established conclusion of previous studies showing that the most effective technique in reducing propofol pain is IV lidocaine given with a tourniquet as a Bier’s block before the injection of propofol (2,3).

REFERENCES

  1. Koo SW, Cho SJ, Kim YK, Ham KD, Hwang JH. Small-dose ketamine reduces the pain of propofol injection. Anesth Analg 2006;103:1444–7[Abstract/Free Full Text]
  2. Picard P, Tramer MR. Prevention of pain on injection with propofol: a quantitative systematic review. Anesth Analg 2000; 90:963–9[Abstract/Free Full Text]
  3. Johnson RA, Harper NJ, Chadwick S, Vohra A. Pain on injection of propofol: methods of alleviation. Anaesthesia 1990; 45:439–42[Web of Science][Medline]



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S.-W. Koo, S.-J. Cho, Y.-K. Kim, K.-D. Ham, and J.-H. Hwang
Ketamine for Reducing Propofol-Induced Pain
Anesth. Analg., August 1, 2007; 105(2): 540 - 540.
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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2007 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press