| Study |
Type of patients, surgery |
Dose
|
End points |
Vomiting/no. of patients
|
Ondansetron
|
Metoclopramide
|
Ondansetron
|
Metoclopramide
|
| Alexander and Fennelly (10) |
Adults, ortho |
8 mg |
10 mg |
V,N,R |
11 /42 |
26% |
18 /42 |
43% |
| Alon and Himmelseher (11) |
Fem, D&C |
8 mg |
10 mg |
V,N,R |
3 /22 |
14% |
12 /22 |
55% |
| Ascaso et al. (12) |
Adults, cataract |
4 mg |
10 mg |
V,N |
1 /116 |
1% |
3 /51 |
6% |
| Chen et al. (13) |
Fem, Gyn |
4 mg |
10 mg |
V,N,R |
16 /25 |
64% |
13 /24 |
54% |
| Desilva et al. (14) |
Fem, laparotomy |
4 mg |
10 mg |
R |
21 /58 |
36% |
29 /58 |
50% |
| Furst and Rodarte (15) |
Peds, T & A |
0.15 mg/kg |
0.5 mg/kg |
V,R |
16 /61 |
26% |
34 /59 |
58% |
| Malins et al. (17) |
Fem, gyn |
4 mg |
10 mg |
V,N |
3 /50 |
6% |
7 /50 |
14% |
| Monagle et al. (18) |
Fem, gyn |
4 mg |
0.4 mg/kg |
V,N,R |
2 /30 |
7% |
4 /34 |
12% |
| Morris et al. (19) |
Fem, gyn |
4 mg |
10 mg |
V,N,R |
262 /465 |
56% |
289 /462 |
63% |
| Naguib et al. (20) |
Adults, lap chole |
4 mg |
10 mg |
V,R |
10 /29 |
34% |
17 /24 |
71% |
| Paxton et al. (21) |
Fem, laparoscopy |
4 mg |
10 mg |
V,N,R |
6 /32 |
19% |
12 /29 |
41% |
| Pugh et al. (22) |
Adults, craniotomy |
8 mg |
10 mg |
V,N,R |
12 /30 |
40% |
7 /30 |
23% |
| Raphael and Norton (23) |
Fem, laparoscopy |
4 mg |
10 mg |
V |
8 /61 |
13% |
25 /62 |
40% |
| Rose and Martin (24) |
Peds, T & A |
0.15 mg/kg |
0.25 mg/kg |
V |
9 /40 |
23% |
16 /40 |
40% |
| Rose et al. (25) |
Peds, strabismus |
0.15 mg/kg |
0.25 mg/kg |
V,R |
9 /30 |
30% |
16 /30 |
53% |
| Scuderi et al. (27) |
Peds, strabismus |
0.1 mg/kg |
0.25 mg/kg |
V,R |
11 /40 |
28% |
16 /40 |
40% |
| Shende and Mandal (28) |
Peds, strabismus |
0.15 mg/kg |
0.25 mg/kg |
V |
22 /64 |
34% |
32 /52 |
62% |
| Stene et al. (29) |
Peds, T & A |
0.15 mg/kg |
0.25 mg/kg |
V |
11 /43 |
26% |
22 /41 |
54% |
Watts (30)
|
Fem, gyn
|
4 mg
|
10 mg
|
N
|
12 /59
|
20%
|
13 /55
|
24%
|
| n = 2502 (ondansetron n = 1297, metoclopramide n = 1205). |
| Ortho = orthopedic surgery, V = vomiting, N = nausea, R = rescue antiemetic medication, Fem = female, Gyn = gynecologic surgery, Peds = pediatrics, T & A = tonsillectomy and adenoidectomy, Lap chole = laparoscopic cholecystectomy, D & C = dilation and curettage. |
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