| Study |
Type of patients, surgery |
Dose
|
End points |
Vomiting/no. of patients
|
Droperidol
|
Metoclopramide
|
Droperidol
|
Metoclopramide
|
| Alon and Himmelseher (11) |
Fem, D & C |
1.25 mg |
10 mg |
V,N,R |
10 /22 |
45% |
12 /22 |
55% |
| Cohen et al. (50) |
Fem, D & C |
1.25 mg |
10 mg |
V,N |
11 /29 |
38% |
16 /28 |
57% |
| Desilva et al. (14) |
Fem, laparotomy |
1.25 mg |
10 mg |
R |
13 /55 |
24% |
29 /58 |
50% |
| Fujii et al. (51) |
Fem, lap chole |
1.25 mg |
10 mg |
V,N,R |
5 /30 |
17% |
6 /30 |
20% |
| Fujii et al. (52) |
Fem, gyn |
1.25 mg |
10 mg |
V,N,R |
7 /30 |
23% |
9 /30 |
30% |
| Fujii and Tanaka (53) |
Peds, mixed |
50 µg/kg |
0.25 mg/kg |
V,R |
6 /25 |
24% |
8 /25 |
32% |
| Fujii et al. (54) |
Fem, gyn |
1.25 mg |
10 mg |
V,N,R |
9 /45 |
20% |
8 /45 |
18% |
| Fujii et al. (55) |
Fem, breast |
1.25 mg |
10 mg |
V,N,R |
5 /30 |
17% |
7 /30 |
23% |
| Fujii et al. (56) |
Fem, gyn |
1.25 mg |
10 mg |
V,N,R |
8 /30 |
27% |
9 /30 |
30% |
| Fujii et al. (57) |
Fem, gyn |
25 µg/kg |
0.2 mg/kg |
V,N,R |
9 /40 |
23% |
11 /40 |
28% |
| Furst and Rodarte (15) |
Peds, T & A |
75 µg/kg |
0.5 mg/kg |
V,R |
36 /58 |
62% |
34 /59 |
58% |
| Kauste et al. (59) |
Fem, ortho |
1.25 mg |
20 mg |
V,N,R |
10 /37 |
27% |
15 /36 |
42% |
| Korttila et al. (60) |
Fem, ortho |
1.25 mg |
10 mg |
V,N,R |
6 /36 |
17% |
13 /37 |
35% |
| Kymer et al. (61) |
Peds, strabismus |
0.3 mg/kg |
0.15 mg/kg |
V |
11 /41 |
27% |
26 /42 |
62% |
| Lin et al. (62) |
Peds, eye |
75 µg/kg |
0.15, 0.25 mg/kg |
V |
9 /27 |
33% |
25 /53 |
47% |
| Liu et al. (63) |
Peds, hernia |
50 µg/kg |
0.15 mg/kg |
V |
1 /20 |
5% |
1 /20 |
5% |
| Madej and Simpson (64) |
Fem, minor gyn |
2.5 mg |
10 mg |
V,N,R |
3 /48 |
6% |
3 /50 |
6% |
| Madej and Simpson (65) |
Fem, major gyn |
2.5 mg |
10 mg |
N |
19 /49 |
39% |
30 /48 |
63% |
| Pandit et al. (66) |
Fem, laparoscopy |
10, 20 µg/kg |
10 mg |
V |
3 /40 |
8% |
4 /20 |
20% |
| Paxton et al. (21) |
Fem, laparoscopy |
1.0 mg |
10 mg |
V,N,R |
14 /29 |
48% |
12 /29 |
41% |
| Pendeville et al. (67) |
Peds, strabismus |
10 µg/kg |
0.1 mg/kg |
V,N |
3 /26 |
12% |
1 /25 |
4% |
Scuderi et al. (27)
|
Peds, strabismus
|
75 µg/kg
|
0.25 mg/kg
|
V,R
|
10 /40
|
25%
|
16 /40
|
40%
|
| n = 1584 (droperidol n = 787, metoclopramide n = 797). |
| Ortho = orthopedic surgery, V = vomiting, N = nausea, R = rescue antiemetic medication, Fem = female, Gyn = gynecologic surgery, Peds = pediatrics, T & A = tonsillectomy and adenoidectomy, Lap chole = laparoscopic cholecystectomy, D & C = dilation and curettage. |
|
