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LETTERS TO THE EDITOR

Propofol Formulation and Pain on Injection

Professor and Holder of the Margaret Milam McDermott Distinguished Chair in Anesthesiology, Department of Anesthesiology & Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, TX

To the Editor:

In the recently published brief report by Rau et al. (1), the investigators described the effect of a "new" emulsion formulation of propofol on the severity of pain on IV injection when compared to Diprivan^® (AstraZeneca, Wilmington, DE). Unfortunately, these authors failed to acknowledge a report by Shao et al. (2) which demonstrated that generic formulation of propofol containing a different preservative (sodium meta-bisulfite) (Baxter, Chicago, IL) was also associated with less severe pain on injection than the EDTA-containing Diprivan formulation. It is important to perform a care-ful review of the published literature on a given topic to properly acknowledge the relevant work of others in the field.

References

1. Rau J, Roizen MF, Doenicke AW, et al. Propofol in an emulsion of long- and medium-chain triglycerides: the effect on pain. Anesth Analg 2001; 93: 382–4.[Abstract/Free Full Text]
2. Shao X, Li H, White PF, et al. Bisulfite-containing propofol: is it a cost-effective alternative to Diprivan for induction of anesthesia? Anesth Analg 2000; 91: 871–5.[Abstract/Free Full Text]

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