Author/study population
|
Quality score
|
Groups
|
Efficacy
|
Williams et al. (73)/718 patients with osteoarthritis of the knee
|
3 |
Placebo |
Celecoxib 100 mg BID = celecoxib 200 mg BID > placebo
|
|
Celecoxib 100 mg BID |
|
|
Celecoxib 200 mg BID |
|
Zhao et al. (74)/1004 patients with osteoarthritis of the knee
|
3 |
Placebo |
Celecoxib 100 mg BID > celecoxib 200 mg BID = naproxen 500 mg BID > celecoxib 50 mg BID > placebo
|
|
Celecoxib 50 mg BID |
|
|
Celecoxib 100 mg BID |
|
|
Celecoxib 200 mg BID |
|
|
|
Naproxen 500 mg BID |
|
Bensen et al. (75)/1003 patients with osteoarthritis of the knee
|
4 |
Placebo |
Celecoxib 100 mg BID = celecoxib 200 mg BID = naproxen 500 mg BID > celecoxib 50 mg BID > placebo
|
|
Celecoxib 50 mg BID |
|
|
Celecoxib 100 mg BID |
|
|
Celecoxib 200 mg BID |
|
|
|
Naproxen 500 mg BID |
|
| Ehrich et al. (76)/219 patients with |
5 |
Placebo |
Rofecoxib 25 mg QD = rofecoxib 125 mg QD > placebo
|
| osteoarthritis of the knee |
|
Rofecoxib 25 mg QD |
|
|
Rofecoxib 125 mg QD |
|
Day et al. (77)/809 patients with osteoarthritis of the knee or hip
|
5 |
Placebo |
Rofecoxib 12.6 mg QD = rofecoxib 25 mg = ibuprofen 800 mg TID > placebo
|
|
Rofecoxib 12.5 mg QD |
|
|
Rofecoxib 25 mg QD |
|
|
|
Ibuprofen 800 mg TID |
|
Saag et al. (78)/736 patients with osteoarthritis of the knee or hip
|
5 |
Placebo |
Rofecoxib 12.5 mg QD = rofecoxib 25 mg QD = ibuprofen 800 mg TID > placebo
|
|
Rofecoxib 12.5 mg QD |
|
|
Rofecoxib 25 mg QD |
|
|
|
Ibuprofen 800 mg TID |
|
Cannon et al. (79)/784 patients with osteoarthritis of the knee or hip
|
3 |
Rofecoxib 12.5 mg QD |
Rofecoxib 12.5 mg QD = rofecoxib 25 mg QD = diclofenac 50 mg TID
|
|
Rofecoxib 25 mg QD |
|
|
Diclofenac 50 mg TID |
|
McKenna et al. (80)/182 patients with osteoarthritis of the knee
|
5 |
Placebo |
Celecoxib 200 mg QD = rofecoxib 50 mg QD > placebo
|
|
Celecoxib 200 mg QD |
|
|
Rofecoxib 50 mg QD |
|
| Geba et al. (81)/382 patients with |
5 |
Rofecoxib 12.5 mg QD |
Rofecoxib 25 mg QD > rofecoxib 12.5 mg QD = celecoxib 200 mg QD > APAP 4000 mg
|
|
|
Rofecoxib 25 mg QD |
|
|
Celecoxib 200 mg QD |
|
|
|
Acetaminophen (APAP) 4000 mg |
|
Fiechtner et al. (82)/642 patients with osteoarthritis of the knee
|
2 |
Placebo |
Valdecoxib 5.0 mg BID = valdecoxib 10 mg BID = valdecoxib 10 mg QD = naproxen 500 mg BID > valdecoxib 1.25 mg BID > placebo = valdecoxib 0.5 mg BID |
|
Valdecoxib 0.5 mg BID |
|
|
Valdecoxib 1.25 mg BID |
|
|
Valdecoxib 5 mg BID |
|
|
Valdecoxib 10 mg BID |
|
|
|
Valdecoxib 10 QD |
|
|
|
Naproxen 500 mg BID |
|
Kivitz et al. (83)/1019 patients with osteoarthritis of the knee
|
5 |
Placebo |
Valdecoxib 10 mg QD = valdecoxib 20 mg QD = naproxen 500 mg BID > valdecoxib 5 mg QD = placebo
|
|
Valdecoxib 5 mg QD |
|
|
Valdecoxib 10 mg QD |
|
|
Valdecoxib 20 mg QD |
|
|
|
Naproxen 500 mg BID |
|
Makarowski et al. (84)/467 patients with osteoarthritis of the hip
|
3 |
Placebo |
Valdecoxib 10 mg QD = naproxen 500 mg BID > valdecoxib 5 mg QD = placebo
|
|
Valdecoxib 5 mg QD |
|
|
Valdecoxib 10 mg QD |
|
|
|
Naproxen 500 mg BID |
|
Simon et al. (85)/1149 patients with rheumatoid arthritis
|
5 |
Placebo |
Celecoxib 100 mg BID = celecoxib 200 mg BID = celecoxib 400 mg BID = naproxen 500 mg BID > placebo
|
|
Celecoxib 100 mg BID |
|
|
Celecoxib 200 mg BID |
|
|
Celecoxib 400 mg BID |
|
Emery et al. (86)/655 patients with rheumatoid arthritis
|
3 |
Celecoxib 200 mg BID |
Celecoxib 200 mg BID = diclofenac 75 mg BID |
|
Diclofenac 75 mg BID |
|
