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Table 4. Analgesic Efficacy
Author/study population
 Quality score
 Groups
 Efficacy
Williams et al. (73)/718 patients with osteoarthritis of the knee
 3 Placebo Celecoxib 100 mg BID = celecoxib 200 mg BID > placebo
Celecoxib 100 mg BID
Celecoxib 200 mg BID
Zhao et al. (74)/1004 patients with osteoarthritis of the knee
 3 Placebo Celecoxib 100 mg BID > celecoxib 200 mg BID = naproxen 500 mg BID > celecoxib 50 mg BID > placebo
Celecoxib 50 mg BID
Celecoxib 100 mg BID
Celecoxib 200 mg BID
Naproxen 500 mg BID
Bensen et al. (75)/1003 patients with osteoarthritis of the knee
 4 Placebo Celecoxib 100 mg BID = celecoxib 200 mg BID = naproxen 500 mg BID > celecoxib 50 mg BID > placebo
Celecoxib 50 mg BID
Celecoxib 100 mg BID
Celecoxib 200 mg BID
Naproxen 500 mg BID
Ehrich et al. (76)/219 patients with 5 Placebo Rofecoxib 25 mg QD = rofecoxib 125 mg QD > placebo
osteoarthritis of the knee Rofecoxib 25 mg QD
Rofecoxib 125 mg QD
Day et al. (77)/809 patients with osteoarthritis of the knee or hip
 5 Placebo Rofecoxib 12.6 mg QD = rofecoxib 25 mg = ibuprofen 800 mg TID > placebo
Rofecoxib 12.5 mg QD
Rofecoxib 25 mg QD
Ibuprofen 800 mg TID
Saag et al. (78)/736 patients with osteoarthritis of the knee or hip
 5 Placebo Rofecoxib 12.5 mg QD = rofecoxib 25 mg QD = ibuprofen 800 mg TID > placebo
Rofecoxib 12.5 mg QD
Rofecoxib 25 mg QD
Ibuprofen 800 mg TID
Cannon et al. (79)/784 patients with osteoarthritis of the knee or hip
 3 Rofecoxib 12.5 mg QD Rofecoxib 12.5 mg QD = rofecoxib 25 mg QD = diclofenac 50 mg TID
Rofecoxib 25 mg QD
Diclofenac 50 mg TID
McKenna et al. (80)/182 patients with osteoarthritis of the knee
 5 Placebo Celecoxib 200 mg QD = rofecoxib 50 mg QD > placebo
Celecoxib 200 mg QD
Rofecoxib 50 mg QD
Geba et al. (81)/382 patients with 5 Rofecoxib 12.5 mg QD Rofecoxib 25 mg QD > rofecoxib 12.5 mg QD = celecoxib 200 mg QD > APAP 4000 mg
Rofecoxib 25 mg QD
Celecoxib 200 mg QD
Acetaminophen (APAP) 4000 mg
Fiechtner et al. (82)/642 patients with osteoarthritis of the knee
 2 Placebo Valdecoxib 5.0 mg BID = valdecoxib 10 mg BID = valdecoxib 10 mg QD = naproxen 500 mg BID > valdecoxib 1.25 mg BID > placebo = valdecoxib 0.5 mg BID
Valdecoxib 0.5 mg BID
Valdecoxib 1.25 mg BID
Valdecoxib 5 mg BID
Valdecoxib 10 mg BID
Valdecoxib 10 QD
Naproxen 500 mg BID
Kivitz et al. (83)/1019 patients with osteoarthritis of the knee
 5 Placebo Valdecoxib 10 mg QD = valdecoxib 20 mg QD = naproxen 500 mg BID > valdecoxib 5 mg QD = placebo
Valdecoxib 5 mg QD
Valdecoxib 10 mg QD
Valdecoxib 20 mg QD
Naproxen 500 mg BID
Makarowski et al. (84)/467 patients with osteoarthritis of the hip
 3 Placebo Valdecoxib 10 mg QD = naproxen 500 mg BID > valdecoxib 5 mg QD = placebo
Valdecoxib 5 mg QD
Valdecoxib 10 mg QD
Naproxen 500 mg BID
Simon et al. (85)/1149 patients with rheumatoid arthritis
 5 Placebo Celecoxib 100 mg BID = celecoxib 200 mg BID = celecoxib 400 mg BID = naproxen 500 mg BID > placebo
Celecoxib 100 mg BID
Celecoxib 200 mg BID
Celecoxib 400 mg BID
Emery et al. (86)/655 patients with rheumatoid arthritis
 3 Celecoxib 200 mg BID Celecoxib 200 mg BID = diclofenac 75 mg BID
Diclofenac 75 mg BID





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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press