Author/study population
|
Quality score
|
Groups
|
Efficacy
|
Schnitzer et al. (87)/658 patients with rheumatoid arthritis
|
3 |
Placebo |
Rofecoxib 50 mg QD = rofecoxib 25 mg QD > rofecoxib 5 mg QD = placebo
|
|
Rofecoxib 5 mg QD |
|
|
Rofecoxib 25 mg QD |
|
|
|
Rofecoxib 50 mg QD |
|
Bensen et al. (88)/1089 patients with rheumatoid arthritis
|
2 |
Placebo |
Valdecoxib 40 mg QD = valdecoxib 20 mg QD = valdecoxib 10 mg QD = naproxen 500 mg BID > placebo
|
|
Valdecoxib 10 mg QD |
|
|
Valdecoxib 20 mg QD |
|
|
Valdecoxib 40 mg QD |
|
|
|
Naproxen 500 mg BID |
|
Dougados et al. (90)/246 patients with ankylosing spondylitis
|
3 |
Placebo |
Celecoxib 100 mg BID = ketoprofen 100 mg BID > placebo
|
|
Celecoxib 100 mg BID |
|
|
Ketoprofen 100 mg BID |
|
Ekman et al. (91)/443 patients with acute ankle sprain
|
3 |
Placebo |
Celecoxib 400 mg = ibuprofen 2400 mg > placebo |
|
Celecoxib 400 mg/d |
|
|
|
Ibuprofen 2400 mg/d |
|
Petrella et al. (92)/397 patients with acute ankle sprain
|
2 |
Celecoxib 200 mg BID |
Celecoxib 200 mg BID = naproxen 500 mg BID |
|
Naproxen 500 mg BID |
|
Bertin et al. (93)/202 patients with acute shoulder pain
|
2 |
Celecoxib 200 mg BID |
Celecoxib 200 mg BID = naproxen 500 mg BID |
|
Naproxen 500 mg BID |
|
Reuben and Connelly (94)/60 patients undergoing spinal fusion
|
2 |
Placebo |
Rofecoxib 50 mg > celecoxib 200 mg > placebo |
|
Rofecoxib 50 mg |
|
|
|
Celecoxib 200 mg |
|
Bekker et al. (95)/61 patients undergoing lumbar disk surgery
|
4 |
Placebo |
Rofecoxib 50 mg > placebo |
| |
|
Rofecoxib 50 mg |
(morphine requirement decreased 37%) |
Reicin et al. (96)/218 patients undergoing major orthopedic surgery
|
5 |
Placebo |
Rofecoxib 50 mg = naproxen 550 mg > rofecoxib |
|
Rofecoxib 25 mg |
25 mg > placebo |
|
|
Rofecoxib 50 mg |
|
|
|
Naproxen 550 mg |
|
Reuben et al. (97)/60 patients undergoing arthroscopic knee surgery
|
4 |
Placebo |
Rofecoxib 50 mg before surgery > 50 mg after surgery > placebo
|
|
Rofecoxib 50 mg before surgery |
|
|
Rofecoxib 50 mg after surgery |
|
Issioui et al. (98)/68 patients undergoing orthopedic surgery
|
3 |
Placebo |
Celecoxib 200 mg = rofecoxib 50 mg = ibuprofen 800 mg > placebo
|
|
Celecoxib 200 mg |
|
|
Rofecoxib 50 mg |
|
|
|
Ibuprofen 800 mg |
|
Gimbel et al. (99)/418 patients undergoing ambulatory orthopedic surgrey
|
3 |
Placebo |
Celecoxib 200 mg TID > hydrocodone 10/1000 TID > placebo
|
|
Celecoxib 200 mg TID |
|
Hydrocodone 10/1000 |
|
|
|
TID (10 mg/APAP 100 mg) |
|
Desjardins et al. (100)/223 patients valdecoxib 20 mg > placebo
|
5 |
Placebo |
Valdecoxib 80 mg = valdecoxib 40 mg > valdecoxib 20 mg > placebo
|
|
Valdecoxib 20 mg |
|
|
Valdecoxib 40 mg |
|
|
|
Valdecoxib 80 mg |
|
Camu et al. (101)/217 patients undergoing hip arthroplasty
|
2 |
Placebo |
Valdecoxib 40 mg BID = 20 mg BID > placebo (morphine requirement decreased 40%)
|
|
Valdecoxib 20 mg BID |
|
|
Valdecoxib 40 mg BID |
|
Issioui et al. (103)/112 patients undergoing ear-nose-throat surgery
|
3 |
Placebo |
Celecoxib 200 mg/APAP 2 g > celecoxib 200 mg = APAP 2 g = placebo
|
|
Acetaminophen 2 g |
|
|
Celecoxib 200 mg |
|
|
|
Celecoxib 200 mg/acetaminophen 2 g |
|
Issioui et al. (104)/68 patients undergoing ear-nose-throat surgery
|
3 |
Placebo |
Rofecoxib 50 mg = rofecoxib 50 mg/APAP 2 g > APAP 2 g = placebo
|
|
Aetaminophen (APAP) 2 g |
|
|
Rofecoxib 50 g |
|
|
|
Aetaminophen 2 g/rofecoxib 50 mg |
|
