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Anesth Analg 2003;97:196-204
© 2003 International Anesthesia Research Society


ECONOMICS, EDUCATION, AND HEALTH SYSTEMS RESEARCH

Computer-Based Anesthesiology Paging System

John P. Abenstein, MSEE MD*, Jonathan A. Allan, MSSE{dagger}, Jennifer A. Ferguson, MS{ddagger}, Steven D. Deick, BSE{dagger}, Steven H. Rose, MD*, and Bradly J. Narr, MD*

*Department of Anesthesiology, {dagger}Division of Engineering and Technology Services, and {ddagger}Division of Systems and Procedures, Mayo Clinic, Rochester, Minnesota

Address correspondence and reprint requests to John P. Abenstein, MSEE, MD, Department of Anesthesiology, Mayo Clinic, 200 First St., SW, Rochester, MN 55905. Address e-mail to abenstein.john{at}mayo.edu


    Abstract
 Top
 Abstract
 Introduction
 Design Criteria
 Discussion
 References
 
For more than a century, Mayo Clinic has used various communication strategies to optimize the efficiency of physicians. Anesthesiology has used colored wooden tabs, colored lights, and, most recently, a distributed video paging system (VPS) that was near the end of its useful life. A computer-based anesthesiology paging system (CAPS) was developed to replace the VPS. The CAPS uses a hands-off paradigm with ubiquitous displays to inform the practice where personnel are needed. The system consists of a dedicated Ethernet network connecting redundant central servers, terminal servers, programmable keypads, and light-emitting diode displays. Commercially available hardware and software tools minimized development and maintenance costs. The CAPS was installed in >200 anesthetizing and support locations. Downtime for the CAPS averaged 0.144 min/day, as compared with 24.2 min/day for the VPS. During installation, neither system was available and the department used beepers for communications. With a beeper, the median response time of an anesthesiologist to a page from a beeper was 2.78 min, and with the CAPS 1.57 min; this difference was statistically significant (P = 0.021, t67 = 2.36).We conclude that the CAPS is a reliable and efficient paging system that may contribute to the efficiency of the practice.

IMPLICATIONS: Mayo Clinic installed a computer-based anesthesiology paging system (CAPS) to inform operating suite personnel when assistance is needed in procedure and recovery areas. The CAPS is more reliable than the system it replaced. Anesthesiologists arrive at a patient’s bedside faster when they are paged with the CAPS than with a beeper.


    Introduction
 Top
 Abstract
 Introduction
 Design Criteria
 Discussion
 References
 
The efficient management of operating suites requires careful resource management. Most expenses of a health care organization are personnel related (1), and successful management of medical personnel determines whether an operational unit is a revenue center or a cost center (2,3). Patient outcomes, particularly in anesthesiology, depend on the availability of expensive personnel, especially physicians (4,5). In a crisis, rapid mobilization of trained personnel is critical to successful resolution (6).

Mayo Clinic has a long history of efficient management of personnel, by which the knowledge and expertise of its physicians are leveraged through extensive use of allied health personnel. One strategy, implemented >100 yr ago, is the use of visual communication systems to direct physicians and allied health personnel to where they are needed. This began with the introduction of colored wooden door tabs. Each color denoted the state of a room. For example, a green tab indicated that the patient was in the room and ready to be seen by a nurse. A blue tab indicated that the patient was ready to be seen by a physician. A red tab indicated that help was needed for an emergency.

This communication strategy spread from the outpatient practice to the hospitals, including the operating suites. Subsequently, door tabs were replaced by colored electric lights. A chime was sounded when the state of a room changed. This communication strategy was thought to improve the efficiency and quality of care in the operative environment. In 1981, a new operating suite was opened at Saint Marys Hospital, 1 of 2 hospitals associated with Mayo Clinic. This prompted updating the communication technology at both hospitals. Electric lights were replaced with video displays suspended from the ceilings or mounted on the walls in the operating rooms (OR), procedure rooms, and support areas.

This Video Paging System (VPS) used alphanumeric codes to communicate the state of each patient care location (7). Pages were initiated by use of electromechanical switches in each OR, procedure room, and preoperative and postoperative location. When a switch was closed (by pushing a button), an alphanumeric code, designating both the location and the individual needed, would be displayed throughout the operative or procedural suite, and in every procedure room, hallway, recovery and waiting area, lounge, office, and cafeteria. In addition, an emergency code was incorporated to rapidly direct staff to a particular location when a cardiac arrest, airway emergency, or other critical event occurred.

Over time, several problems emerged with the VPS. The black-and-white monitors that displayed the pages burned in after about 18 mo, making the displays unreadable. Replacement monitors were costly and difficult to find. The software was difficult to maintain, and software constraints became unacceptable as the practice grew and evolved. When seven additional ORs were built at Saint Marys Hospital, and OR numbering changed from two digits to three digits, the VPS could not accommodate the change. These problems triggered the decision to replace the VPS with a new communication system.


    Design Criteria
 Top
 Abstract
 Introduction
 Design Criteria
 Discussion
 References
 
Several types of devices were examined as possible solutions. Cell phones, digital pagers, and personal digital assistants were considered to possibly be less expensive and more flexible solutions than the existing hardwired approach. However, these options were rejected as being too dependent on personnel. If the paged individual did not respond, there would be no way to know whether the correct beeper was called, whether the person was unavailable, or to whom the page should be redirected. To respond to a page, one must interact with these devices, which can be impractical during procedures. It was concluded that a hands-free system would be designed and implemented.

With little review or documentation, the VPS had evolved on an ad hoc basis with additional functions and a broader geographic distribution. Missing comprehensive system documentation made determining where the current system was used and what information was transmitted challenging. A careful analysis of new requirements was completed, redundant and unnecessary functions were eliminated, and the geographic distribution of the new system was planned.

Prototyping technologic solutions occurred simultaneously. A distributed video architecture was rejected because of its inherent instability. Because the cathode-ray tube displays had only an 18- to 24-mo useful life, liquid crystal and light-emitting diode (LED) displays were considered. LED displays were chosen because they have a useful life of at least 15 yr and a greater luminosity that prevents washout from fluorescent and natural lighting. These displays are relatively expensive, but the cost can be amortized over a longer useful life. Choosing the size of the characters on the displays was a trade-off between the distance at which the displays could be read and the required information content. The size and information layout of the LED displays were determined by their expected placement, for example how low the displays could hang from hallway ceilings. The decision was made to develop in-house a configurable, centrally programmable keypad that would replace the electromechanical switches.

Several distribution architectures were considered. Use of the institutional Ethernet network was an attractive, inexpensive option, but pages could be delayed when network bandwidth demand was greatest. Because pages are time-sensitive, this risk was deemed unacceptable. Therefore, an independent Ethernet network was chosen to drive the system. The computer-based anesthesiology paging system (CAPS) was designed to be upgradeable and easily configured. Software running on standard hardware is more easily adaptable and requires fewer maintenance personnel. Use of commercially available components also reduces costs for development and maintenance (Fig. 1).



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Figure 1. Hardware and software components of the computer-based anesthesiology paging system. Sample active calls are shown on the displays at the right, and a keypad layout with hot keys assigned is shown at the left. SNMP = simple network management protocol.

 
System Specifications
The CAPS runs on dual-processor, redundant Compaq servers (Compaq Computer, Houston, TX) using SQL Server 7.0 under the Windows NT 4.0 operating system (Microsoft, Redmond, WA). Because the system is used as an emergency indicator, continuous availability is required. A redundant Central Processing Unit architecture satisfies this up time requirement. Software was written in Microsoft’s Visual Basic 6.0 and Visual C++ 6.0. The distribution architecture is a star pattern of Ethernet and RS-422 devices connected by standard Category-5 cable. Terminal servers connect the RS-422 protocol LED displays and the programmable keypads to the Ethernet network. The server can send daily electronic mail with system statistics and maintenance needs. The CAPS can send a page to a beeper for urgent maintenance problems (Fig. 1). The server software connects to the terminal server ports (one device per port) via device controllers. A simple network management protocol manager restarts failed connections without manual intervention.

The software design optimizes the handling of new pages to assure the shortest possible time between placing a page and seeing it on the LED displays. If there are no active emergency pages, all new pages are processed and displayed within 1.5 s. The user initiates a page by either pressing a dedicated microswitch (hot key) or entering a numeric code on the keypad (Fig. 2). The page is sent to the keypad controller via the terminal server. The keypad controller associates the page with a specific keypad, the keypad’s workgroup (e.g., neurologic anesthesia or vascular radiology), and other necessary information. The page is then presented via a Microsoft ActiveX Data Object call to the SQL Server database engine. The database determines what text is to be displayed on the LED displays and then forwards the text to the queue manager. The database then returns control to the keypad controller, which illuminates an LED above the activated hot key. If a page for a physician or nurse is initiated from an OR, a light above that room’s door illuminates as a wayfinding aid.



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Figure 2. Gane and Sarson notation dataflow diagram for the computer-based anesthesiology paging system. A new page is represented as beginning in the upper left and flowing to the right. LCD = liquid crystal display, LED = light-emitting diode.

 
The queue manager determines the workgroups for a new page and inserts the new page either into those groups’ new-page queues or emergency queues. Although there are seldom >15 active calls, each queue may hold up to 100 calls. At 1.5-s intervals, the display controllers query the queue manager for the next page. The display controller then forwards that page to each display. If the page is displayed for the first time, a chime sounds. The current time, synchronized with the atomic clock in Boulder, CO, is displayed in the upper right corner, except when emergency pages are displayed. The display controllers then perform housekeeping chores (e.g., querying displays for functional status), during the remainder of the 1.5-s interval before querying the queue manager for the next page. After a page has been displayed once, it is placed in the active-page queue. The queue manager then cycles through this queue while any pages are active. Emergency pages are not placed in the active-page queue. When an emergency page is initiated, it is the only page shown on the LED displays, the light above the room door blinks, and the chime is sounded repeatedly until the page is answered. In the unlikely event that two or more emergency pages are active simultaneously, only the emergency pages are cycled until answered.

The central servers, terminal servers, operating system, and database are all commercial products. The LED displays were initially custom-made products, but the manufacturer has subsequently added them to their standard product line. These displays are located throughout the hospitals where anesthesia services are provided or anesthesia personnel congregate.

The programmable keypads were designed in-house and were assembled and tested under contract. The keypads can accept new embedded code downloaded from the server. This allows for remote reprogramming of the keypads without maintenance personnel physically interacting with each keypad (i.e., removing >450 keypads from the wall and reprogramming them with a laptop computer). Therefore, upgrading the keypads is rapid and cost-effective.

An administrative program and several specialized tools for maintenance personnel were developed. The administrative program’s graphical user interface masks the relational database’s complexity and presents a more simplified view of the system. Pages, devices, reports, and other aspects of the system can be managed without use of the development engineering group. This feature allows maintenance personnel to be trained technicians, thereby decreasing the total cost of ownership and freeing the development engineering staff for other projects.

User Functionality
The CAPS presents two kinds of pages: 1) class page, which is a page for a class of individuals to come to a patient location, and 2) person page, which is a page for a specific individual to come to a multiple-patient location. Class pages have three parts. The prefix characters are alphabetic, denoting the work area (e.g., "N" for the north anesthesia area or "CL" for the catheterization laboratory). The middle characters denote the room number within that work group (e.g., "N 808" for room 808 in the north anesthesia area or "CL 109" for room 109 in the catheterization laboratory). The suffix character denotes the class of person needed in the room. Therefore, complete pages would be "N 808 A," meaning that an anesthesiologist is needed in room 808 in the north anesthesia area, or "CL 109 N," meaning that a nurse anesthetist is needed in room 109 of the catheterization laboratory. Person pages have two parts. The prefix denotes a multiple-patient location (e.g., "P" for postanesthesia care unit or "o" for outpatient recovery). The other characters are numeric, denoting the individual needed. Therefore, a complete person page would be "P49," meaning that person "49" is needed in the postanesthesia care unit.

Using CAPS is reasonably straightforward. For example, if a resident physician in cardiac catheterization room 104 needs to confer with the attending anesthesiologist, the resident pushes the "Physician" button on the keypad mounted on the anesthesia machine (Fig. 3). An LED above the button illuminates, confirming that the page has been received. Every monitor throughout the cardiac catheterization suite, including the room initiating the page, displays "CL 104 A" in green and chimes briefly (Fig. 4). The page remains on the LED display for 1.5 s as the system cycles from page to page. A page cycles every 1.5 s until it is deactivated by a person; there is no timeout feature for pages. When the attending anesthesiologist enters the room and pushes the "Physician" button, the page is no longer displayed anywhere and the LED above the button turns off. If the resident considers the page to be urgent, the resident pushes the "Urgent" button (Fig. 3) and then the "Physician" button; "CL 104 A" would appear in orange and cycles with any other pages. If there is an emergency in the procedure room, the two side-by-side emergency buttons are pushed simultaneously (Fig. 3). This action persistently displays "CL 104 A" in bright red on every display in the catheterization laboratory, and a chime rings until the emergency buttons in the room are pushed simultaneously. In the unusual event of >1 simultaneous emergency page, the display will cycle from emergency page to emergency page every 1.5 s, sounding the chime persistently, until all emergency pages are deactivated.



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Figure 3. Keypad for the computer-based anesthesiology paging system shown with three of the eight hot keys assigned to anesthesiologist, certified registered nurse anesthetist (CRNA), and technician. LCD = liquid crystal display, LED = light-emitting diode.

 


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Figure 4. Light-emitting diode display is mounted on the ceiling in the operating suite hallway. Indicator lights are seen above the operating room (OR) doors. Additional displays are mounted on the ceiling in the background. The page "D408 A" is requesting the anesthesiologist responsible for OR 408, in workgroup "D," to come to room 408.

 
This same basic feature is available throughout the environment of the CAPS. A hot key is pushed on the keypad and the defined page is displayed throughout the respective operating or procedural suite. Other examples of possible pages are shown in Table 1. The hot keys can vary from keypad to keypad. For example, in the operating suite, anesthesiologists and certified registered nurse-anesthetists are the only licensed providers with hot keys, whereas in the cardiac catheterization laboratory, a hot key pages registered nurses who provide sedation care. The system has the ability to add many additional pages through use of the numeric keys (Fig. 3). For example, by pressing "246" followed by the "Enter" key, a unique page can be displayed, such as "CL 104 MP" for medical photographer. The keypad screen (Fig. 3) displays the keyed page, confirming to the user that the page has been received. If >1 page is entered via the keypad, instead of the hot keys, the pages are cycled every 1.5 s on the keypad’s screen.


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Table 1. Examples of Displayed Pages
 
The LED displays are more useful than the VPS cathode-ray tube monitors, which displayed a maximum of only four black-and-white characters. Like the CAPS, the VPS prefix character designated the workgroup, two digits identified the room number, and the suffix character indicated the personnel being paged. The CAPS displays allow a prefix, a room identifier, and a suffix, for a maximum of 10 characters that can be illuminated in 1 of 3 colors. Rooms can be specified by numbers, short words, or abbreviations. Without the limitations of the VPS, formerly cryptic pages are now displayed in unambiguous text. Whereas "P888" in the VPS meant that the postanesthesia care unit was full, this page is now displayed unambiguously on the CAPS as "PACU FULL."

When anesthesia and OR personnel hear the "new call" chime, they can glance at the display and read the new call. If they miss seeing the new page, the system offers shortcuts so one does not need to watch all the pages cycle through the display. Personnel indicators in the lower left corner of the display (Fig. 5) identify the class of individual required (e.g., anesthesiologist, nurse, or technician). Zone indicators in the upper left corner of the display identify the work areas that have active calls (e.g., "N" for north anesthesia and "B" for cardiovascular anesthesia). If an anesthesiologist responsible for the B zone hears a new page chime but misses seeing the new page, the anesthesiologist can glance at the display (Fig. 5) and observe that the new call was for someone else (e.g., if only "D" is seen in the upper left of the display, only D zone personnel have active pages). If "B" is in the upper left and if "A" is not in the lower left, then the anesthesiologist no longer needs to look at the display because the new page was for someone else. Pages are sorted numerically within the zone, so people need to watch the display only until the codes for their rooms are either displayed or passed over. The personnel and zone shortcut indicators are cumulative for all active pages and are displayed for all except emergency pages.



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Figure 5. Programmable keypad mounted to the right of the anesthesia machine. A telephone and a perioperative information management system are also available for communication. Above the anesthesia machine is a light-emitting diode display. The page "D408 N" is requesting the certified registered nurse anesthetist responsible for operating room 408, in workgroup "D," to come to the room.

 
Postimplementation Review
At Mayo Clinic, each of the two hospitals has a CAPS. During the first 6 mo of operation, there were 8 h of unexpected downtime. There were four additional hours of planned downtime for installing lower priority functions, downloading keypad corrections, installing operating system patches, and correcting miscellaneous problems. After this initial shake-down period, the CAPS was down a total of 14 min in 3 mo (i.e., 0.144 min/day). In contrast, the VPS was down an average of 28.3, 29.7, 21.9, and 16.8 min/day in 1996, 1997, 1998, and 1999, respectively. Starting in 2000, the reliability of the VPS began to deteriorate compared with its historic norms. The deterioration became another issue that helped initiate the CAPS project. Despite the difficulty of comparing old and new technologic systems, the data show that the CAPS is more reliable than was the VPS.

Clinical Evaluation
During the installation of the CAPS, there was a brief period during which neither the VPS nor the CAPS was available in all areas. The VPS was removed in segments as the CAPS was installed, and beepers were used temporarily as a bridging communications medium. Anesthesiologists and nurse anesthetists have used beepers for many years for person-to-person communications, such as consultations and outside telephone calls, and as a means to reach individuals when they are outside of the video paging environment (e.g., intensive care units and hospital wards). Because departmental personnel were experienced and comfortable with beepers and telephones are mounted on every anesthesia machine, it was decided to use these devices during the transition from the VPS to the CAPS. This allowed comparison of the efficiency of using beepers with the efficiency of using the CAPS.

Observations of paging with beepers occurred during a 4-day period, 2 days at each hospital. Each day, different ORs were studied on the basis of the implementation schedule of the CAPS. Data were gathered from within a randomly selected OR by recording the time a page was initiated to a beeper (beginning as the number was being dialed) and the time the responder entered the room. Because of the limitation of being able to observe only 1 OR at a time and the rapid installation of the CAPS, relatively few pages with beepers were observed (n = 12), all of which were routine, nonurgent calls. When the study was designed, it was expected that there would be 6 days of installation per hospital and, therefore, 12 days of observation for gathering beeper response times. Unfortunately for the study, but fortuitous for the practice, installation took only 2 days per hospital, which reduced the expected number of observations. The original CAPS installation schedule allowed more time for system verification in each work area than was actually needed and so the time allotted for beeper observations was significantly reduced.

Similarly, observations for the CAPS occurred over a 4-day period, 2 days at each hospital. Data were gathered by recording the time a page appeared on the LED display, which was within 1.5 s of the time the button was pressed from within the OR, and the time the responder entered the room. Because the CAPS displays its pages on LED displays located throughout the surgical suite, several ORs could be observed simultaneously by watching the displays, and more data were collected (n = 57). No urgent or emergency pages were observed.

The median response time for anesthesiologists paged with a beeper was 2.78 min (range, 1.00–7.23 min). Problem pages did occur, including incorrect beeper numbers that were given to next-shift personnel, multiple pages that were made because the caller was not certain that the correct number had been dialed, and missed or ignored pages that required repaging. The median response times for anesthesiologists paged with the CAPS was 1.57 min (range, 0.30–7.20 min). Because of the CAPS design, none of the problem pages observed with the beepers were observed with the CAPS. These results are summarized in Table 2 and Figure 6. A logarithmic transformation was applied to the data to satisfy the distributional assumptions required for the two-sample Student’s t-test. The t-test of the transformed data showed a statistically significant difference between the response times with beepers and the response times with the CAPS (P = 0.021, t67 = 2.36). The CAPS had a shorter response time for anesthesiologists than the beeper method.


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Table 2. Response Time of Anesthesiologists Paged with a Beeper Versus Paged with the CAPS
 


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Figure 6. Response time is compared for paging via a beeper versus with the computer-based anesthesiology paging system (CAPS).

 

    Discussion
 Top
 Abstract
 Introduction
 Design Criteria
 Discussion
 References
 
Mayo Clinic anesthesiologists generally are responsible for more concurrent procedures than is common in an academic practice. For example, one anesthesiologist concurrently cares for two pediatric open-heart patients at Mayo Clinic, whereas the norm is one procedure per anesthesiologist at Duke and Stanford Universities (personal communication). Although there is no hard evidence that the CAPS directly allows for higher concurrency, the anesthesiology department and the institution have concluded that the CAPS is an important tool that allows for these ratios with safe delivery of anesthesia care. The reasoning is that when an anesthesiologist is busy caring for a patient in one location (e.g., placing a pulmonary artery catheter or inducing anesthesia) and is paged to another location, the page remains visible until it is answered. This prompts colleagues to answer the page, thereby ensuring that clinical problems are rapidly addressed. The system is used to indicate cardiac arrests and other emergencies, initiating an immediate response from many available personnel. The system is also used to page personnel in other services, such as the clinical laboratory, autotransfusion, surgical pathology, and housekeeping. By allowing communication with many groups, the CAPS can be used to manage procedural areas more efficiently.

The design of the system is consistent with the communication philosophy that has developed at Mayo Clinic in both inpatient and outpatient environments. Patient care sites are equipped with a communication tool that identifies the state of the room. For the anesthesiology practice, the state of the room reflects the personnel needs in the room. If an anesthesiologist is needed, a visual page is displayed throughout the work environment informing both the anesthesiologist and the practice as a whole that assistance is requested in the procedure room. The postimplementation review demonstrates that the CAPS is more reliable than the system it replaced, with an average downtime of less than one minute per day.

When comparing the CAPS with a system of beepers, which are the standard communication devices in many medical centers, the time to answer a page was statistically significantly less when the page was initiated using the CAPS than using a beeper and the opportunity for communication errors are eliminated. This study has a number of limitations. The sample size of beeper paging is small (n = 12). However, we have no reason to believe that these data are not representative of our beeper paging system. Also, although a statistically significant difference in response time was detected between the beeper system and the CAPS, the clinical relevance of this difference is unclear. The clinical relevance of 1.21 minutes response time depends on the clinical situation that prompted the page. If a page is initiated to discuss fluid management, it is unlikely that the observed shorter response time would make any difference. However, if the page is to secure assistance for an airway-related problem, then 1.21 minutes could make a significant difference.

Another limitation of the study is that patient outcome data were not recorded as part of our data collection. All the pages observed were for routine matters (e.g., anesthesia induction, emergence, or routine questions). No emergencies or urgent pages were recorded in either group. A review of the CAPS database shows that there were 7 emergency pages during April 2002 when the paging system covered 97 ORs, 5 recovery rooms, and >46 nonoperative anesthetizing locations. The emergency pages were answered in an average of 35 ± 23 seconds. However, there are no data to compare this with emergency response to beeper pages. A much larger study would have to be undertaken to demonstrate an effect on patient outcomes. Although such a study was considered, the anesthesiology practice concluded that it was unwilling to investigate the clinical effect of paging without the CAPS because of concerns for patient safety and practice efficiency.

The CAPS has a subtle effect on the environment of the operating suite because there is not a constant din of overhead audio pages. Instead, a brief chime announces a new page to the entire staff. Anesthesiologists in the ORs are not straining to hear garbled pages. Anesthesiology residents and certified registered nurse anesthetists are not waiting in frustration, wondering whether their pages have been heard. Pages are persistently visible on ubiquitous displays until answered.

Mayo Clinic is a large group practice (>1000 attending physicians), and it can be difficult to ensure accountability of all members in a large organization (8). One drawback of using beepers is that staff may ignore or forget pages. With the CAPS, everyone in the procedural suites can see pages and be aware of pages that are not answered. The primary value of Mayo Clinic is "the needs of the patient come first." Adherence to this principle encourages staff to respond to unanswered pages. However, even with assistance from colleagues, a continual pattern of ignoring pages becomes apparent. The CAPS promotes assistance from colleagues when a staff member is occupied with another patient and inhibits a pattern of unanswered pages in a manner not recognized by the anonymity of beepers. As a result, staff members are reluctant to have their pages displayed longer than necessary, even though there is no visible duration associated with any given page. The practice-wide result is that staff attend to the needs of patients in a timely manner without authoritarian management measures.

The CAPS was designed to be a hands-free, reliable, and low-maintenance communication system. The system is more reliable than the VPS it replaced. The development and installation of the CAPS is associated with anesthesiologists responding more rapidly to paging with the CAPS than to paging with beepers. This may be associated with improved patient outcomes and greater OR efficiency.


    References
 Top
 Abstract
 Introduction
 Design Criteria
 Discussion
 References
 

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Accepted for publication February 5, 2003.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press