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Anesth Analg 2004;98:1197-1198
© 2004 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000112307.87820.B1


EDITORIAL

Electroanalgesia: Does It Have a Place in the Routine Management of Acute and Chronic Pain?

Paul F. White, PhD MD, FANZCA

Dr. White is the Professor and Holder of the Margaret Milam McDermott Distinguished Chair of Anesthesiology, Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas

Address correspondence to Dr. Paul F. White, PhD, MD, Professor and Holder of the Margaret Milam McDermott, Distinguished Chair in Anesthesiology, Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390–9068. Address email to paul.white{at}utsouthwestern.edu

The role of nonpharmacologic analgesic modalities in the treatment of chronic pain syndromes has long been questioned by medical practitioners because of a lack of adequately powered, prospective, randomized, double-blind sham-controlled studies supporting their use in clinical practice (1–3). According to Smith et al. (1) most valid trials with acupuncture for chronic back and neck pain "tended to be negative." Interestingly, the authors of this systematic review drew their "own conclusions (positive/negative)" based on their interpretation of these data. The article by Sator-Katzenschlager et al. (4) in the current issue of the journal describing a prospective, randomized sham-controlled study involving auricular acupuncture contributes to the growing body of scientific data supporting the use of electroanalgesic modalities in the management of chronic low back pain (CLBP) (5–11).

Analogous to earlier sham-controlled studies involving the use of percutaneous electrical nerve stimulation in the short-term management of CLBP (5–9), Sator-Katzenschlager found significant benefits of electro- (versus manual) acupuncture with respect to lower pain scores, improved "sense of well-being," physical activity, and quality of sleep, and a reduced need for oral analgesic medication (4). The current investigation extends these earlier studies by also evaluating the longer-term benefits of electroanalgesia in the CLBP population. Of significant importance from the societal perspective, the CLBP patients receiving electrostimulation were able to return to full-time work earlier as a result of their improved quality of life. In a placebo-controlled study, Carlsson and Sjolund (10) also suggested that electroacupuncture has long-term beneficial effects in patients with CLBP.

The study by Sator-Katzenschlager et al. (4) further documents the advantage of direct electrical (versus mechanical) needle stimulation in enhancing the analgesic benefits of acupuncture in patients with CLBP. In patients with acute pain, the intensity of the electrical stimulus was one of the primary determinants of its analgesic efficacy (12). Interestingly, well controlled studies involving the use of manual intradermal acupuncture needles have also demonstrated impressive benefits in the perioperative setting (13). Although the current study involved the use of an auricular acupuncture point, it is possible that similar results could have been achieved with electrical stimulation at other acupoints (14), and/or specific dermatomes (5–9) corresponding to the patient’s pain symptoms. In fact, it has been demonstrated, using an acute pain model, that identical analgesic benefits can be achieved by stimulating at either an acupoint or the corresponding dermatomal levels (14).

One of the major benefits of the auricular acupuncture device relates to its small size and the ability of the therapy to be administered on an ambulatory basis, obviating the need for frequent clinic visits to receive treatments. Comparative studies are needed to evaluate efficacy of transcutaneous electrical stimulation of the auricular acupuncture point (15) and the percutaneous auricular electroacupuncture technique utilized in the study by Sator-Katzenschlager et al. (4). It will also be important to determine how long the beneficial effects of auricular acupuncture persist after the therapy is discontinued.

Further research is clearly needed to establish the role of simple electroanalgesic techniques such as auricular acupuncture and percutaneous neuromodulation therapy in the multimodal management of acute (15), subacute (16), and chronic pain syndromes (4–11) as well as for treating more serious medical conditions (17). Although auricular acupuncture has been widely used to treat both cocaine and alcohol addiction, recently published randomized, controlled clinical trials have failed to demonstrate any clinically-significant benefits of this therapy in improving patient outcome (18–20). Controversy also exists regarding the role of the "placebo" effect of electroacupuncture when it is used to supplement to other analgesic and physiotherapy modalities in the management of CLBP (11,21). Despite lingering skepticism in the medical community (1–3,21), a growing body of scientific data based on carefully conducted prospective, randomized, placebo (or sham) controlled clinical trials (4–11) suggests that electroanalgesic techniques can be valuable adjuncts to conventional medical approaches in the management of CLBP.

In summary, electroanalgesia is likely to become a more widely used adjuvant to other analgesic modalities for the management of a wide variety of acute and chronic pain syndromes (22). Perhaps all patients with pain can live better with electricity!

Acknowledgments

Supported, in part, by endowment funds from the Margaret Milam McDermott Distinguished Chair in Anesthesiology.

References

  1. Smith LA, Oldman AD, McQuay HJ, Moore RA. Teasing apart quality and validity in systematic reviews: an example from acupuncture trials in chronic neck and back pain. Pain 2000; 86: 119–32.[Web of Science][Medline]
  2. Ezzo J, Berman B, Hadhazy VA, et al. Is acupuncture effective for the treatment of chronic pain? Pain 2000; 86: 217–25.[Web of Science][Medline]
  3. Ernst E, White AR, Wider B. Acupuncture for back pain: meta-analysis of randomized controlled trials and an update with data from the most recent studies. Schmerz 2002; 16: 129–39.[Web of Science][Medline]
  4. Sator-Katzenschlager SM, Scharbert G, Kozek-Langenecker SA, et al. Short- and long-term benefit in chronic low back pain through adjuvant electrical versus manual auricular acupuncture. Anesth Analg 2004; 98: 1359–64.[Abstract/Free Full Text]
  5. Ghoname EA, Craig WF, White PF, et al. Percutaneous electrical nerve stimulation for low back pain: a randomized cross-over study. JAMA 1999; 281: 818–23.[Abstract/Free Full Text]
  6. Ghoname EA, Craig WF, White PF, et al. The effect of stimulus frequency on the analgesic response to percutaneous electrical stimulation in patients with chronic low back pain. Anesth Analg 1999; 88: 841–6.[Abstract/Free Full Text]
  7. Ghoname EA, White PF, Ahmed HE, et al. Percutaneous electrical nerve stimulation: an alternative to TENS in the management of sciatica. PAIN 1999; 83: 193–9.[Web of Science][Medline]
  8. Hamza MA, Ghoname EA, White PF, et al. Effect of the duration of electrical stimulation on the analgesic response in patients with low back pain. Anesthesiology 1999; 91: 1622–7.[Web of Science][Medline]
  9. White PF, Craig WF, Vakharia AS, et al. Percutaneous neuromodulation therapy: does the location of electrical stimulation effect the acute analgesic response? Anesth Analg 2000; 91: 949–54.[Abstract/Free Full Text]
  10. Carlsson CPO, Sjolund BH. Acupuncture for chronic low back pain: a randomized placebo-controlled study with long-term follow-up. Clin J Pain 2001; 17: 296–305.[Web of Science][Medline]
  11. Molsberger AF, Mau J, Pawelec DB, Winkler J. Does acupuncture improve the orthopedic management of chronic low back pain: a randomized, blinded, controlled trial with 3-months follow-up. Pain 2002; 99: 579–87.[Web of Science][Medline]
  12. Wang B, Tang J, White PF, et al. Effect of the intensity of transcutaneous acupoint electrical stimulation on the postoperative analgesic requirement. Anesth Analg 1997; 85: 406–13.[Abstract]
  13. Kotani N, Hashimoto H, Sato Y, et al. Preoperative intradermal acupuncture reduces postoperative pain, nausea and vomiting, analgesic requirement, and sympathoadrenal responses. Anesthesiology 2001; 96: 349–56.
  14. Chen L, Tang J, White PF, et al. The effect of location of transcutaneous electrical nerve stimulation on postoperative opioid analgesic requirement: acupoint versus nonacupoint stimulation. Anesth Analg 1998; 87: 1129–34.[Abstract/Free Full Text]
  15. Greif R, Laciny S, Mokhtarani M, et al. Transcutaneous electrical stimulation of an auricular acupuncture point decreases anesthetic requirement. Anesthesiology 2002; 96: 306–12.[Web of Science][Medline]
  16. Borg-Stein J, Seroussi RE, Gomba L, et al. Safety and efficacy of percutaneous neuromodulation therapy in the management of subacute radiating low back pain. Pain Prac 2003; 3: 125–34.
  17. Wong AMK, Leong CP, Su TY, et al. Clinical trial of acupuncture for patients with spinal cord injuries. Am J Phys Med Rehab 2003; 82: 21–7.[Web of Science][Medline]
  18. Margolin A, Kleber HD, Avants SK, et al. Acupuncture for the treatment of cocaine addiction: a randomized controlled trial. JAMA 2002; 87: 55–63.
  19. Bullock ML, Kiresuk TJ, Sherman RE, et al. A large randomized placebo controlled study of auricular acupuncture for alcohol dependence. J Sub Abuse Treat 2002; 22: 71–7.[Web of Science][Medline]
  20. Trumpler F, Oez S, Stahli P, et al. Acupuncture for alcohol withdrawal: a randomized controlled trial. Alcohol Alcohol 2003; 38: 369–75.[Abstract/Free Full Text]
  21. Leibing E, Leonhardt U, Koster G, et al. Acupuncture treatment of chronic low-back pain: a randomized, blinded, placebo-controlled trial with 9-month follow-up. Pain 2002; 96: 189–96.[Web of Science][Medline]
  22. White PF, Li S, Chiu JW. Electroanalgesia: its role in acute and chronic pain management. Anesth Analg 2001; 92: 505–13.[Abstract/Free Full Text]
Accepted for publication November 25, 2003.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2004 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press