IMPLICATIONS: During a brief period of ischemia during minimally invasive direct coronary artery bypass grafting, cardiac function was better preserved with sevoflurane compared with propofol.
IMPLICATIONS: In a patient population without cardiac disease, portal triad clamping could be performed safely during laparoscopy, despite a decrease in left ventricular function and the occurrence of regional wall motion abnormalities.
IMPLICATIONS: The clavicle's deltoid tuberosity may reflect an alternative anatomic landmark to simplify subclavian vein cannulation by minimizing patient manipulation and anatomic measurements.
IMPLICATIONS: Dexmedetomidine exerts a protective effect against hypoxia-reoxygenation-induced left ventricular dysfunction, and this effect is mediated through {alpha} 2-adrenergic stimulation before and during the hypoxic period.
IMPLICATIONS: More than half of patients (54%) who were treated with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor subtype 1 antagonists (ARA) up to 24 h before surgery developed hypotension after anesthetic induction. Discontinuation of ACEI/ARA therapy at least 10 h before anesthesia was associated with a reduced risk of immediate postinduction hypotension.
IMPLICATIONS: Clinicians may underestimate the blood loss and fluid replacement implications of a given volume of blood return by cell salvage devices. This review provides guidelines for estimating total blood loss and appropriate colloid and crystalloid replacement volumes based on the volume of red cell concentrate recovered.
IMPLICATIONS: This study determined the incidence of awareness during anesthesia in children. Eight-hundred-sixty-four children aged 5 to 12 yr who had undergone general anesthesia were interviewed on 3 occasions to determine the incidence of awareness. Seven (0.8%) children had episodes of awareness. No aware child reported distress.
IMPLICATIONS: Using electrical stimulation one may potentially distinguish the epidural space from the intrathecal space.
IMPLICATIONS: This case report emphasizes the practical, emergent use of a laryngeal mask airway to secure the airway of a pediatric patient in the prone position after accidental extubation.
IMPLICATIONS: A child with unsuspected Duchenne muscular dystrophy developed hyperkalemic cardiac arrest after cardiac surgery using cardiopulmonary bypass. Prompt intervention, including recognition and management of hyperkalemia, resulted in a successful outcome.
IMPLICATIONS: Intensive preoperative IV rehydration reduces the incidence and severity of postoperative nausea and vomiting (PONV) in high risk patients undergoing ambulatory surgery. This prospective, randomized, controlled, double-blind clinical trial demonstrates that perioperative hydration with a balanced salt solution at 2 mL/kg per hour of fasting effectively reduces PONV and postoperative pain in high risk patients undergoing gynecologic laparoscopy.
IMPLICATIONS: We studied the effect of preinjection with bacteriostatic saline, an agent with known anesthetic properties, on the incidence of pain associated with the IV injection of propofol. We found that it decreases the incidence and severity of pain, and the decrease is comparable to that of mixing lidocaine with propofol.
IMPLICATIONS: Dexmedetomidine decreased the convulsive potency of racemic bupivacaine and levobupivacaine by increasing their convulsive dose and plasma and brain concentrations at the onset of convulsions. Because this anticonvulsant effect was antagonized by yohimbine, an {alpha}2-adrenoceptor antagonist, dexmedetomidine would exert its anticonvulsant effect via the {alpha}2-adrenoceptor.
IMPLICATIONS: Restoration of protective airway reflexes occurs significantly sooner after anesthesia with desflurane than after anesthesia with sevoflurane.
IMPLICATIONS: Target-controlled infusion of GPI 15715, a water-soluble prodrug of propofol, was successfully performed in volunteers to achieve and maintain moderate sedation for 2 h. A propofol concentration of 1.9 {micro}g/mL appeared to be appropriate for moderate sedation.
IMPLICATIONS: To gain a better understanding of the cardiovascular and toxic actions of the chiral local anesthetics bupivacaine and ropivacaine, we have examined the effects of their individual enantiomers on coronary vascular resistance in isolated perfused hearts.
IMPLICATIONS: Frakefamide, a novel potent analgesic, did not impair resting ventilation while morphine caused significant depression, supporting a peripheral action only of frakefamide.
IMPLICATIONS: This study shows minimal bias and excellent correlation between the dominant and nondominant adductor pollicis muscle. According to the results, both hands can be used interchangeably to assess neuromuscular blockade at the adductor pollicis muscle.
IMPLICATIONS: Extravasation injury results from a combination of factors, including cytotoxicity, solution osmolality, vasoconstrictor properties, infusion pressure, regional anatomical peculiarities, and other patient factors. We report extravasation injury in the perioperative setting. Vasoactive drugs and hyperosmolar and concentrated electrolyte solutions are the predominant vesicants in this setting.
IMPLICATIONS: This study shows that epidural anesthesia produced sedative effects during both the awake phase and during sevoflurane general anesthesia. Sedative effects associated with the epidural anesthesia were more prominent during general anesthesia than during the awake phase.
IMPLICATIONS: The short-acting {beta}1-adrenoceptor antagonists esmolol and landiolol blunted the increase of heart rate and suppressed the increase of bispectral index after tracheal intubation under general anesthesia with 1 minimum alveolar anesthetic concentration sevoflurane.
IMPLICATIONS: Our results indicate that heat loss from dry or wet skin is comparable when subjects are covered with a new surgical drape impervious to fluid (Tiburon) and when they are covered with conventional surgical drapes. Hypothermia or hyperthermia is thus no more likely to occur when using the Tiburon than conventional drapes.
IMPLICATIONS: Occasionally the forehead pulse oximeter wave form takes on features suggestive of a venous signal rather than the normal arterial signal. It is suggested that this may be a source of error when determining arterial oxygen saturation.
IMPLICATIONS: The USCOM is a new portable cardiac output monitor based on continuous-wave Doppler imaging. We tested its reliability against an aortic flowprobe reference in anesthetized dogs.
IMPLICATIONS: This meta-analysis assesses the ability of preemptive analgesic interventions to attenuate postoperative pain scores, decrease supplemental postoperative analgesic requirements, and prolong time to first rescue analgesic request. Using these outcome measures, preemptive analgesia showed an overall beneficial effect after epidural analgesia, local wound infiltration, and systemic nonsteroidal antiinflammatory drug administration.
IMPLICATIONS: We found that resiniferatoxin prevents pain caused by incision. Vanilloid agonists provide a type of neural blockade when postoperative pain is abolished while preserving nonpainful sensations and motor functions.
IMPLICATIONS: These are the first case reports from clinical practice demonstrating the successful use of the new transdermal formulation of buprenorphine for the treatment of neuropathic pain and nociceptive pain with significant neuropathic components.
IMPLICATIONS: Cost comparisons of anesthesia techniques largely depend on the surgical duration of the cases studied. Even in a teaching hospital setting, spinal anesthesia has economic advantages over general anesthesia. Especially for short cases, brachial plexus block is more expensive in this setting.
IMPLICATIONS: In a double-blind, randomized, placebo-controlled study, we studied oral clonidine 100 {micro}g given before surgery and 24 h after surgery to determine a clinically relevant anxiolytic effect, especially in patients with moderate to intense pain. We found that clonidine might be a useful therapeutic alternative to other preoperative sedatives.
IMPLICATIONS: Advanced medical simulation of prehospital trauma care was used to assess gaps in performance by physician graduates of the advanced trauma life support course. The resulting data were used to change the training curriculum, inducing improvement in performance assessed by the same simulative scenarios.
IMPLICATIONS: Propofol successfully attenuated physiological, biochemical, and pathologic changes in acute lung injury associated with endotoxemia in rabbits. However, the effect of propofol on fibroproliferative lung damage and on outcome in humans remains to be elucidated.
IMPLICATIONS: In a hamster skin flap model we demonstrated that in traumatized tissue, lactate/pyruvate ratio is more appropriate than lactate to detect ischemic hypoxia. However, both markers may be increased as a result of trauma itself. This markedly reduces their specificity to detect ischemic hypoxia in the presence of trauma.
IMPLICATIONS: We demonstrated by in vitro experiments with septic rats that sepsis stage-dependently and differentially attenuates the actions of nondepolarizing neuromuscular blockers. Late sepsis more intensely attenuates the actions than does early sepsis. The sepsis-induced attenuations were largest for pancuronium, second largest for rocuronium, and smallest for d-tubocurarine.
IMPLICATIONS: The effects of recombinant human basic fibroblast growth factor (bFGF) on angiogenesis in a rabbit ear chamber model of wound healing were studied chronologically. Initial angiogenesis was significantly accelerated by a single local application of bFGF, whereas capillary density at the completion of vascularization did not differ from control.
IMPLICATIONS: Propofol significantly increases, and sevoflurane significantly decreases cerebral vascular tone as assessed by changes in zero flow pressure. Thus, despite moderate decreases in mean arterial blood pressure, the estimated cerebral perfusion pressure is preserved during sevoflurane, but not during propofol anesthesia.
IMPLICATIONS: Etomidate had an apparently adverse effect on short-term histologic status after temporary focal cerebral ischemia in rats. The results suggest that the adverse effect was mediated by inhibition of nitric oxide synthase by etomidate.
IMPLICATIONS: In a rat model of spinal cord ischemia, both gray and white matter were injured and the degree of white matter injury was correlated with the severity of gray matter injury. Assessments of both gray and white matter injury may be important for evaluation of therapeutic efficacy against ischemic spinal cord injury.
IMPLICATIONS: The overall incidence of cardiac arrest during spinal or epidural anesthesia was 1.8 per 10,000 blocks between 1988 and 2002. Patients who experienced a cardiac arrest during neuraxial anesthesia had an equal or greater likelihood of survival than those who arrested during general anesthesia.
IMPLICATIONS: The addition of clonidine 1 {micro}g/kg in the initial bolus followed by clonidine 1 {micro}g/mL in the postoperative infusion during continuous femoral nerve block after total knee arthroplasty does not provide clinically relevant advantages in terms of improving postoperative analgesia, but it potentially delays the recovery of motor function.
IMPLICATIONS: IV but not perineural clonidine (1 {micro}g/kg), prolongs time to first supplementary analgesic administration after psoas compartment block with levobupivacaine 0.5% in patients undergoing hip fracture surgery.
IMPLICATIONS: We report a case of postdural puncture headache associated with abdominal pain and diarrhea. An epidural blood patch was performed, and all symptoms resolved after 5 days. After exclusion of organic and psychological disorders, this treatment might be considered for patients who are experiencing abdominal pain and diarrhea after dural puncture.
IMPLICATIONS: Epidural hematomas may be related to patient, surgical, or anesthetic variables. This epidural hematoma occurred in a patient with ankylosing spondylitis receiving aspirin for thromboprophylaxis after total hip replacement and was unrelated to the combined spinal-epidural anesthetic.
IMPLICATIONS: Capnogram shape was used to separate obstructive lung disease subjects from normals and subjects with restrictive lung disease. Changes in the capnogram shape correlated with changes in spirometry. This suggests that the capnogram may be useful as a noneffort-dependent method for distinguishing obstructive subjects from normals.
IMPLICATIONS: With low inspiratory flow (V) rates, peak inspiratory airway pressure may fail to indicate progressive obstruction of the endotracheal tube. The decelerating effect of endotracheal tube narrowing on expiratory V, by contrast, can easily and reliably be recognized on the expiratory V-volume plot, making expiratory Vanalysis a helpful monitoring tool.
IMPLICATIONS: A 63-yr-old female patient developed a tracheal necrosis after esophageal resection with gastric interposition. We report the anesthetic management of this patient undergoing tracheal repair focusing on an unusual airway management and ventilation strategy.
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