IMPLICATIONS: ASA status III-V, age >=50 yr, hypotension before induction, and propofol use were all statistically significant independent predictors of hypotension after induction of general anesthesia. Hypotension after induction was associated with adverse outcomes.
IMPLICATIONS: A novel hydroxyethyl starch preparation (HES 130/0.4) has been developed to reduce hemostatic interactions. At a dose of 50 mL/kg, this preparation was associated with similar blood loss compared to gelatin in patients undergoing cardiac surgery with cardiopulmonary bypass.
IMPLICATIONS: Clinicians ought to be aware of the potential side effects of fluoroquinolone drugs. These include hypoglycemia. In the perioperative setting, multiple factors may predispose patients to drug-induced hypoglycemia.
IMPLICATIONS: Some studies in adults found that the Bispectral Index (BIS) decreased as sleep became deeper, providing a nonspecific measure of the subject's level of consciousness. This study investigated the changes of BIS during natural sleep in healthy children.
IMPLICATIONS: Etomidate is a frequently used induction anesthetic in patients with limited hemodynamic reserve. Using invasive hemodynamic monitoring, the acute effects of etomidate during induction of anesthesia in children were studied. The lack of clinically significant hemodynamic changes after etomidate administration supports the notion that etomidate is safe in pediatric practice.
IMPLICATIONS: Isoflurane-induced neurodegeneration was observed in slices cultured from the perinatal rat brain, confirming observations previously reported in vivo. The presence of this phenomenon in vitro will provide an opportunity to define the mechanism of experimental isoflurane-induced neurodegeneration.
IMPLICATIONS: In a fetus with prenatally diagnosed airway obstruction it essential to secure an artificial airway while utero-placental circulation supplies the fetus with oxygen. We describe end-tidal CO2 measurement to prove endotracheal intubation during an ex utero intrapartum treatment procedure.
IMPLICATIONS: Mepivacaine spinal anesthesia was administered to 1210 patients. Transient neurologic symptoms occurred in 6.4% of patients. Intrathecal mepivacaine can be advocated as a spinal anesthetic in the ambulatory setting.
IMPLICATIONS: Acupressure at the Yintang point decreases preoperative parental anxiety. Future studies are needed to quantify the duration of the anxiolytic effect.
IMPLICATIONS: Slow injection, particularly at 30 s, minimizes the incidence of fentanyl-induced cough, and light smoking provides a protective effect against cough.
IMPLICATIONS: Using a crossover comparison, it was shown that Propofol-Lipuro® significantly diminishes pain on injection compared with Diprivan®.
IMPLICATIONS: The effects of ropivacaine, bupivacaine, and levobupivacaine on the heart and blood vessels were compared, in anesthetized rabbits, with doses encountered in routine clinical practice. Ropivacaine may have a greater margin of safety compared with bupivacaine and levobupivacaine because it has the least depressant effect on the heart.
IMPLICATIONS: Increasing duration of anesthesia (the "context") delays recovery from an inhaled anesthetic. Duration, anesthetic solubility, and cardiac output each can materially influence recovery by affecting the time to achieve a particular decrement in concentration (the context-sensitive decrement time). The relationship of these factors is nonlinear.
IMPLICATIONS: We used microarray analysis and identified two genes that were differentially expressed within the narrowly defined Lorp1 quantitative trait locus region affecting propofol sensitivity. Neuronal genes of interest outside the Lorp1 region were also identified that could have an additional role in mediating differential neurosensitivity in these strains.
IMPLICATIONS: Pain on injection and myoclonus are common side effects of etomidate. Magnesium sulfate 2.48 mmol administered 90 s before the induction of anesthesia is effective in reducing the severity of etomidate-induced myoclonic muscle movements.
IMPLICATIONS: The aim of this study was to evaluate the in vitro effects of 4-chloro-3-ethylphenol using cumulative and bolus administrations on muscle specimens from malignant hyperthermia (MH) susceptible and MH nonsusceptible patients, respectively. The cumulative test appears to be feasible for MH diagnosis.
IMPLICATIONS: Antiemetics of the 5-hydroxytryptamine 3A receptor antagonist class inhibit nicotinic acetylcholine receptors and may produce unrecognized side effects.
IMPLICATIONS: Subanesthetic racemic ketamine does not enhance gamma-aminobutyric acid type A receptor binding in the living human brain as assessed with 11C-labeled flumazenil and positron emission tomography.
IMPLICATIONS: We present a patient with restless leg syndrome who had marked leg movement that prevented performance of cervical spine diagnostic studies. The periodic leg movements were eliminated by the administration of physostigmine.
IMPLICATIONS: Opioid receptor desensitization and internalization have been considered as mechanisms for the development of opioid tolerance. Recent studies suggest that receptor internalization may be a way to resensitize opioid receptors and to reduce the development of opioid tolerance. A group of proteins called {beta}-arrestins are involved in opioid receptor internalization.
IMPLICATIONS: We demonstrate that computerized analysis of breath sounds allows the detection of proper endotracheal tube (ETT) position. Our data suggest that this new technique, when incorporated into a 3-component, electronic stethoscope-type device, may be an accurate and portable mechanism to reliably detect ETT malposition in situations where end-tidal CO2 or other methods of determining proper ETT location may be unavailable or unreliable.
IMPLICATIONS: Monitoring cerebral oxygen saturation in elderly patients undergoing major abdominal surgery, we observed that cerebral desaturation can occur in up to one of every five patients and actively optimizing intraoperative cerebral oxygen saturation minimizes brain exposure to hypoxia. This could have the potential for shortening discharge times from the postanesthesia care unit and hospital and minimizing negative effects on cognitive function 1 wk after surgery.
IMPLICATIONS: Barium hydroxide lime, but not soda lime, turns yellow after complete desiccation. The yellow color indicates the potential for anesthetic breakdown. The yellow color may be obscured by tinted canisters, rendering it difficult to use clinically. Partially desiccated barium hydroxide lime may degrade anesthetics but it does not turn yellow.
IMPLICATIONS: Desiccated soda lime degrades desflurane, isoflurane, and sevoflurane to produce heat. Although sevoflurane degradation produces much more heat than degradation of desflurane or isoflurane, the amount of heat produced appears to be less than would produce temperatures that would cause fires.
IMPLICATIONS: We designed a muscle relaxation controller that avoids the usability restrictions of previously described systems. We tested under clinical conditions and found the controller sufficiently accurate, flexible, and robust.
IMPLICATIONS: Every day the anesthesiologist's routine can be complicated by equipment misuse, i.e., the anesthesia machine may be serviced or tampered with between cases. A quick preinduction pressure leak test of the breathing circuit can prevent dangerous sequelae.
IMPLICATIONS: The plasma concentration of ketamine that enhances epidural morphine analgesia may be approximately 20 ng/mL.
IMPLICATIONS: The aim of the study was to evaluate the antinociceptive and antiinflammatory effects and duration of action of several novel depots of ketorolac esters. We found that these depots produced long-acting effects that were 6.5- to 9.5-fold longer than that of the traditional dosage form.
IMPLICATIONS: We investigated the analgesic effect of Neurotropin® in mice with fifth lumber nerve ligation. Neurotropin® dose-dependently showed antiallodynic and antihyperalgesic effects via action at the supraspinal site and activation of spinal noradrenergic systems.
IMPLICATIONS: Oxcarbazepine had a dose-dependent antiallodynic effect in a rat model of neuropathic pain. These results suggest that oxcarbazepine may provide effective therapy for neuropathic pain associated with allodynia and hyperalgesia.
IMPLICATIONS: Parecoxib 5 mg IV was an effective antiinflammatory drug combined with clonidine/lidocaine loco-regional block in complex regional pain syndrome type 1.
IMPLICATIONS: A delayed type of acute tolerance developed to morphine, but not to dexmedetomidine, on acute pain test. The antihyperalgesic effects of morphine were not changed on repeated administration one week later, whereas the potency of dexmedetomidine was increased. There was no sign of cross-tolerance between the two drugs.
IMPLICATIONS: Reports of adverse reactions, specifically anaphylaxis or anaphylactoid reactions to rocuronium and vecuronium, submitted to the Food and Drug Administration were analyzed to assess the differences between the two drugs and differences in reporting patterns between the United States and other countries. The incidence of the reports containing anaphylaxis terms did not differ between vecuronium and rocuronium in the United States but were significantly different for the non-U.S. countries.
IMPLICATIONS: Software that analyzes vital signs from operating rooms can remotely identify the time that a patient enters and leaves a given operating room automatically in real-time. A test in a six operating room suite demonstrated the accuracy of such a system, which has remained in operational use.
IMPLICATIONS: Standard therapy of hemorrhagic shock is intravascular volume replacement concurrent with control of hemorrhage. Prolonged shock of any type results in vasodilatory shock, for which small-dose vasopressin may be useful.
IMPLICATIONS: Saline 0.9% given by IV infusion to conscious septic and nonseptic sheep was rapidly eliminated from the plasma volume by urinary excretion. Plasma volume expansion was similar in both septic and control animals.
IMPLICATIONS: This study demonstrates that bronchodilation and external positive end-expiratory pressure (PEEP) may exert additive beneficial effects in bronchodilator-responsive, mechanically ventilated chronic obstructive pulmonary disease patients with moderate intrinsic PEEP. Benefits include attenuation of dynamic hyperinflation, reduction of respiratory system resistance and static elastance, and improved hemodynamics and gas exchange.
IMPLICATIONS: Intracarotid injection of thiopental during cerebral hypoperfusion significantly increased the duration of electroencephalographic silence. Our results suggest that intracarotid injection of certain drugs during cerebral hypoperfusion could enhance their efficacy.
IMPLICATIONS: In a prospective randomized multicenter study of severely preeclamptic women undergoing cesarean delivery, spinal anesthesia was associated with a larger decrease in arterial blood pressure and required more treatment with ephedrine than did epidural anesthesia. Hypotension was easily treated with ephedrine, and neonatal outcomes were similar for both groups.
IMPLICATIONS: Healthy preterm and severely preeclamptic women undergoing cesarean delivery under spinal anesthesia were compared. Although hypotension occurred in both groups, the incidence of hypotension leading to ephedrine treatment was less frequent in the group with severe preeclampsia and appeared to be attributable to preeclampsia-associated factors.
IMPLICATIONS: Epidural morphine, as part of a multi-modal approach, delayed the first request and resulted in fewer doses of supplemental analgesia after postpartum tubal ligation surgery. These results suggest that epidural morphine 2 mg may be a useful analgesic adjunct for patients who undergo postpartum tubal ligation under epidural anesthesia.
IMPLICATIONS: Injection of lidocaine through the epidural needle into the epidural space before "needle through needle" dural puncture with a pencil-point spinal needle enhances patient comfort by reducing spontaneous movement, spontaneous vocalization, and patient acknowledgment of any physical sensation accompanying insertion of the spinal needle during performance of combined spinal-epidural anesthesia.
IMPLICATIONS: Ultrasound-guided infraclavicular block can be performed as rapidly as supraclavicular block and provides a similar quality of surgical anesthesia.
IMPLICATIONS: The addition of femoral nerve blockade to epidural analgesia significantly improved analgesia for the first 2 days after total knee arthroplasty. Femoral nerve blockade improved flexion on postoperative day 2 but did not affect achievement of other physical therapy milestones.
IMPLICATIONS: Continuous intra- and postoperative thoracic epidural analgesia using bupivacaine and sufentanil decreased the release of brain natriuretic peptide in patients undergoing major abdominal surgery who were at risk for, or had, coronary artery disease.
IMPLICATIONS: We investigated the effect of ketamine sedation on oxidative stress by determining malonyldialdehyde (MDA) and hypoxanthine (HPX) levels during arthroscopic knee surgery with tourniquet under spinal anesthesia. IV 0.5 mg {middle dot} kg-1 {middle dot} h-1 ketamine attenuates lipid peroxidation and ischemia-reperfusion injury in arthroscopic knee surgery requiring tourniquet application.
IMPLICATIONS: The question of which is the optimum technique to intubate the trachea of a patient who may have a cervical(C)-spine injury remains unresolved. Using fluoroscopic video, C-spine motion during intubation was compared for Macintosh 3 blade, GlideScope, and Lightwand use. The Lightwand is associated with reduced C-spine movement during intubation compared to Macintosh laryngoscope.
IMPLICATIONS: Transient global amnesia (TGA) is an amnestic syndrome with an abrupt onset. The hallmark of TGA is a sudden inability to form new memories despite normal neurological function. We report two cases of TGA after general anesthesia.
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