IMPLICATIONS: Sevoflurane protects against myocardial ischemia-reperfusion injury when given before (preconditioning) or after (postconditioning) myocardial ischemia. Both effects provide additive cardioprotection and are mediated at least in part by mitochondrial KATP-channels.
IMPLICATIONS: Isoflurane prevented the ability of platelets to enhance the coronary endothelial dysfunction caused by neutrophils. This effect was associated with reductions in superoxide production and vascular adherence. The current findings provide further evidence that the cardioprotective effects of isoflurane involve inhibitory actions on inflammatory cells and their interactions.
IMPLICATIONS: We demonstrated that positive pressure inflation of the lungs brings about a very rapid increase in myocardial contractile function, in a large animal model. Therefore, positive airway pressure and lung inflation status must be standardized for serial measurements of myocardial contractile function.
IMPLICATIONS: Although transesophageal echocardiography is a crucial tool in evaluation newly implanted prosthetic valves, it is important to be familiar with factors that confound echocardiographic data. Failure in this regard may lead to unwarranted surgical intervention.
IMPLICATIONS: Bi-hemispheric measurements of regional cerebral oxygen saturation using near-infrared spectroscopy were similar in neonates and infants undergoing biventricular repair without aortic arch reconstruction. Further longitudinal neurological outcome studies are required to determine whether uni- or bi-hemispheric monitoring is required in this patient population.
IMPLICATIONS: To create a guideline to avoid intracardiac placement of central venous catheters in infants, we examined the distance from skin to superior vena cava and right atrial junction by using transesophageal echocardiography. The recommended depth of the central venous catheter inserted through right subclavian vein is between 40-55 mm for infants less than 5 kg.
IMPLICATIONS: Methods to control pain after knee surgery include blocking the femoral nerve and injecting medications into the joint. Neither technique is clearly superior. We tested the hypothesis that blocking the sciatic and femoral nerves provides better analgesia than joint injection. Postoperatively, blocked patients had less pain and required less medication.
IMPLICATIONS: A different effect of steroid treatment could be suspected in the neonatal age, especially in the context of ischemia or hypoxia, and the use of steroids has to be reconsidered in critically ill neonates and infants.
IMPLICATIONS: The results of this pilot study suggest that it is possible to convert total shoulder arthroplasty into an outpatient procedure using ambulatory interscalene perineural local anesthetic infusion. Additional data are required to define the appropriate subset of patients and assess the incidence of complications associated with this practice before its mainstream use.
IMPLICATIONS: This randomized, double-blind study evaluated whether small-dose granisetron (0.1 mg) plus dexamethasone 8 mg was as effective as ondansetron 4 mg plus dexamethasone 8 mg for preventing vomiting during the 0 to 2 h after tracheal extubation in patients undergoing abdominal hysterectomy requiring general anesthesia.
IMPLICATIONS: The results of this study indicate that neither ODT ondansetron 8 mg nor IV ondansetron 4 mg is more effective than placebo as prophylaxis for IT morphine-induced postoperative nausea and vomiting in young males. Although both regimens of ondansetron were associated with less frequent IT morphine-induced pruritus than placebo, only the ODT form significantly reduced the severity of pruritus and significantly decreased the need for rescue antipruritic administration.
IMPLICATIONS: In a large population of low risk surgical patients, asymptomatic anemia rarely occurred, and the discovery of this anemia did not change perioperative management. Routine hemoglobin screening for anemia is therefore not indicated in these patients.
IMPLICATIONS: There is a strong relationship between the amount of postoperative opioid used and postoperative vomiting. The accuracy of various risk scoring approaches may have been undermined by not allowing for this relationship. Patients likely to have larger postoperative opioid requirements should be priority targets for opioid reduction or vomiting prevention strategies.
IMPLICATIONS: Neostigmine does not increase postoperative vomiting. However, data on the effect on postoperative nausea remain conflicting and there is insufficient evidence from which to draw strong conclusions.
IMPLICATIONS: During rapid sequence induction of anesthesia in emergent cases, succinylcholine allowed for a more rapid endotracheal intubation sequence and created superior intubation conditions compared with rocuronium. However, there was no difference in the incidence of poor intubation conditions, failed intubation attempts, and desaturations between succinylcholine and rocuronium.
IMPLICATIONS: Increased {alpha}1-acid glycoprotein levels during systemic inflammatory response leads to resistance towards the neuromuscular blocking effects of atracurium. Nitric oxide may modulate {alpha}1-acid glycoprotein synthesis. Suppression of increased nitric oxide levels, however, did not successfully reverse the resistance to atracurium, implying a nitric oxide-independent regulation of {alpha}1-acid glycoprotein.
IMPLICATIONS: The observed reduction of only 0.5{degrees}C in the shivering threshold explains doxapram's efficacy for treatment of postoperative shivering. However, such a reduction is unlikely to markedly facilitate induction of therapeutic hypothermia as a sole drug.
IMPLICATIONS: Patients with sleep apnea syndrome undergoing general anesthesia usually receive no premedication drugs before surgery because of the potential respiratory-depressing effects. Clonidine, an antihypertensive used as premedication, stabilizes hemodynamics during anesthesia and improves postoperative analgesia without disturbing the ventilation pattern in patients with sleep apnea syndrome.
IMPLICATIONS: The {alpha}2-adrenoceptor (AR) subtypes and GIRK1/GIRK2 channels were co-expressed in Xenopus oocytes. IV anesthetics, ethanol, and halothane had no direct effect on any of the {alpha}2-AR subtypes at clinically relevant concentrations. However, the physiological actions of the {alpha}2-ARs mediated by GIRK1/GIRK2 channels may be affected by ethanol and halothane.
IMPLICATIONS: Two hours of isoflurane anesthesia, with or without nitrous oxide, does not impair and may improve the ability of rats to acquire a novel spatial memory task 2 wk later.
IMPLICATIONS: Universal Mobile Telecommunication Systems (UMTS) (WCDMA FDD), Wireless Local Area Network (WLAN) (802.11b), and General Packet Radio Services are three new wireless technologies that could potentially replace hospital pager systems. Electromagnetic provocation tests, between signals and life-supporting equipment, were performed in a clinical setting. The study showed that signals, from UMTS and WLAN, are electromagnetically compatible with the tested equipment.
IMPLICATIONS: We screened for skeletal muscle ryanodine receptor mutations in five Taiwanese patients with malignant hyperthermia (MH) using denaturing high-performance liquid chromatography. We identified the responsible mutations in all patients. This approach has the potential for the development of better genetic tests for MH in the future.
IMPLICATIONS: In a June, 2003 Sentinel Event Alert concerning prevention of surgical fires, the Joint Commission on Accreditation of Healthcare Organizations recommended, as a general policy and consistent with patient needs, supplying open delivery systems such as nasal cannulae with air or <=30% O2. This report analyzes equipment, practice alternatives, and patient safety considerations that address this recommendation.
IMPLICATIONS: The air detector/clamp of the Level 1 H-1200 fluid and blood warmer functioned effectively during simulated minor and massive air embolism and would be expected to prevent lethal air embolism. The use of ultrasonic air detection coupled with automatic shutoff is a significant safety improvement of the Level 1 H-1200 fluid and blood warmer.
IMPLICATIONS: Intrathecal adenosine A1 and A2A receptor agonists reduced acute pain and inflammatory hyperalgesia in the formalin test. Further, the adenosine A1 receptor agonist was more powerful than adenosine A2A and A3 receptor agonists for attenuating acute pain. In contrast, intrathecal adenosine A3 receptor agonist decreased inflammatory hyperalgesia without affecting acute pain.
IMPLICATIONS: Direct epidural injection of gabapentin in rats did not show any neurotoxic evidence in terms of sensory-motor functions and behavior, or by a microscopic histopathological evaluation. This study represents a first promising step toward the trial of epidural gabapentin in a clinical setting.
IMPLICATIONS: Patients subjected to surgery for breast cancer were randomly assigned to receive perioperatively gabapentin, ropivacaine in the operating field, and EMLA around the wound or three placebos. The multimodal analgesia reduced the analgesic requirements significantly and attenuated the acute and chronic pain after surgery when compared with the control group.
IMPLICATIONS: The intraarticular administration of a vanilloid agonist resiniferatoxin inhibits pain behavior in knee joint arthritis. This effect is dose-dependent.
IMPLICATIONS: Impairment among anesthesiology residents is common. Less than half of the rehabilitated residents returning to anesthesia successfully completed training and a significant proportion died as judged by this nationwide survey. Improvement in overall outcome can be achieved through redirection of these individuals into lower risk specialties.
IMPLICATIONS: It is important to increase our knowledge regarding the causes of neurologic function deterioration that frequently accompanies organ failure in sepsis patients. S-100B is a widely used marker for brain damage that potentially can be used to study sepsis effects on the central nervous system.
IMPLICATIONS: Despite interest in pain assessment in the intensive care unit (ICU), there is no specific pain scale for critical care patients and, particularly, for uncommunicative patients. This study demonstrated that a behavioral scale can be valid and reliable for measuring pain in ICU patients.
IMPLICATIONS: Airway management is of major importance in emergency care. In this study, we found that emergency medical technician students could use the laryngeal tube with reasonable success, and this device may provide an alternative solution in emergency airway management.
IMPLICATIONS: Lung contusion is a common problem encountered by victims of motor vehicular accidents. We have developed a rat model for lung contusion that does not involve any significant associated injury to the heart. This model will be helpful in ascertaining the complex mechanisms involved in the pathogenesis of lung contusion.
IMPLICATIONS: Risperidone is an atypical antipsychotic drug used for the treatment of schizophrenia. Although experience with risperidone overdose is limited and the clinical presentation difficult to predict, the possibility of delayed respiratory depression must be kept in mind.
IMPLICATIONS: Although postoperative nausea and vomiting is common (particularly in women) after open craniotomy for acoustic neuroma tumors, treatment with Zofran(R) (IV and oral) significantly reduces the intensity and frequency of this complication.
IMPLICATIONS: Epidural blood patch may be an alternative initial therapy for some low-pressure headaches after lumboperitoneal shunt placement.
IMPLICATIONS: We describe the case of a patient with peripartum cerebral venous sinus thrombosis. It is important to consider this condition when dealing with positional headache.
IMPLICATIONS: Administration of a single-injection dose of local anesthetic through the epidural needle as a priming solution into the epidural space before inserting the catheter improves the quality of epidural anesthesia and reduces the incidence of catheter-related complications.
IMPLICATIONS: Plethysmographic pulse wave amplitude is a reliable alternative to changes in heart rate and systolic blood pressure in detecting intravascular injection of an epinephrine-containing simulated epidural test dose during general anesthesia.
IMPLICATIONS: Spinal injection of small-dose bupivacaine (7.5 mg) was compared to large-dose bupivacaine (12.5 mg). The cardiac output (CO) was depressed in the 12.5 mg group and remained stable in the 7.5 mg group. Small-dose bupivacaine provides successful anesthesia and prevents a decrease in CO.
IMPLICATIONS: Pruritus is the most common side effect of intrathecal morphine. In this study, we evaluated the efficacy of prophylactic administration of ondansetron and dolasetron for prevention of intrathecal morphine-induced pruritus. Both medications offer effective antipruritic prophylaxis, reducing the severity and incidence of pruritus after intrathecal morphine.
IMPLICATIONS: Extensive epidural block (C3-L2) was not able to suppress leukocytosis, lymphopenia, increases in cytokines and C-reactive protein, and changes in proportions of lymphocyte subsets after radical esophagectomy. This suggests that tissue damage and inflammation overcome the effects of extensive epidural block on stress response and immune function after radical esophagectomy.
IMPLICATIONS: When performing the epidural stimulation test, sufficient current can be transmitted with metal-coil reinforced catheters (single or multi-port) but not with conventional plastic catheters.
IMPLICATIONS: Continuous maxillary and mandibular nerve blocks were a significant and novel contribution for management of excision of pleomorphic adenoma in an elderly patient with intractable atrial fibrillation associated with regional wall motion abnormalities, significant reduction of ejection fraction, hypertension, poor chest condition, and difficult airway.
IMPLICATIONS: Laryngoscope-guided tracheal intubation is feasible in microgravity obtained during parabolic flight, but the success rate is infrequent because of severe time restrictions. There were no differences in success rate between the free-floating condition, with the head gripped between the knees, and in the restrained condition, with the torso strapped to the surface.
IMPLICATIONS: Adding less bicarbonates (1.4% versus 8.4%) to lidocaine placed in an endotracheal (ETT) can still be effective in preventing ETT-related emergence phenomena, although it results in a slower release of lidocaine through the ETT cuff. These results were clinically relevant despite thyroid surgery and anesthesia without nitrous oxide.
IMPLICATIONS: Because difficult laryngoscopy is infrequent, the incidence of false negatives is small; nevertheless, the sensitivity of a test should be sufficiently high to detect possible difficulties with laryngoscopy. Measurement of the ratio of height to thyromental distance resulted in less detection failure of difficult laryngoscopy than mouth opening, thyromental distance, neck movement, and oropharyngeal view (modified Mallampati).
IMPLICATIONS: Supplemental perioperative IV fluid administration did not reduce the rate of wound infection. The apparent lack of benefit may have resulted because hydration's effect on intestinal oxygenation is modest or because the statistical power of our study was limited. Nonetheless, our results suggest that supplemental hydration in the range tested does not impact wound infection rate.
IMPLICATIONS: This case report describes a novel way of managing hypoxemia during one-lung ventilation when continuous positive airway pressure to the nondependent lung is not feasible.
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