IMPLICATIONS: Cognitive impairment was found in 45% of women before cardiac surgery. C-reactive protein levels are increased in women with preexisting cognitive impairment, but the relationship between this inflammatory marker and preexisting cognitive impairment is likely secondary to the acute phase reactant serving as a marker for other predisposing conditions.
IMPLICATIONS: We studied the effects of exercise and posture on cardiovascular function and mixed venous oxygen saturation preoperatively and on the first morning after cardiac surgery. Exercise testing demonstrated that cardiovascular function was reduced postoperatively. The response to passive standing indicated that postural change accounts for a substantial part of the mixed venous oxygen desaturation during postoperative mobilization.
IMPLICATIONS: Hypoperfusion of the intestinal mucosa has been suggested to be an important pathogenic mechanism for development of postoperative complications after cardiac surgery. In this study, the autoregulatory response of the intestinal mucosal perfusion to variations in perfusion pressure was found to be well maintained in humans undergoing nonpulsatile cardiopulmonary bypass.
IMPLICATIONS: Early diagnosis of infection after cardiopulmonary bypass improves outcome. Conventional laboratory tests cannot distinguish patients with early infection from those with systemic inflammatory response syndrome but no infection. The aim of this study was to investigate the predictive ability of cytokines such as tumor necrosis factor-{alpha}, interleukin-6, and interleukin-10 for infection after cardiac surgery.
IMPLICATIONS: Endothelial signaling properties ex vivo are altered by systemically present mediators after cardiac surgery with cardiopulmonary bypass but not after less invasive total joint arthroplasty. An increased Ca2+-activated Ca2+ entry mechanism may exist in vivo after highly invasive surgical interventions.
IMPLICATIONS: The results of the present study indicate that N-acetylcysteine does not prevent kidney injury in patients with normal preoperative renal function undergoing surgical repair of the abdominal aorta.
IMPLICATIONS: In the isolated Langendorff heart, amrinone, enoximone, and milrinone dose-dependently produced positive chronotropic, inotropic, and lusitropic effects, although only enoximone and milrinone increased oxygen consumption. Coronary flow reserve was preserved by each drug, indicating an intact coronary autoregulation. In addition, these tested phosphodiesterase inhibitors do not directly cause coronary vasodilation.
IMPLICATIONS: Twenty-two patients experiencing unexpected intraoperative cardiac arrest during noncardiac surgery were evaluated with intraoperative transesophageal echocardiography. Transesophageal echocardiography significantly contributed to determining the etiology of the cardiac arrest in 86% and influenced management in 82% of the patients. Transesophageal echocardiography may be a valuable diagnostic tool when used early during intraoperative cardiac arrest.
IMPLICATIONS: Adolescents who received continuous intraoperative infusion of remifentanil for scoliosis surgery had a significantly larger postoperative analgesic requirement than did those who received intermittent morphine boluses, suggesting that remifentanil infusion is associated with the development of clinically relevant acute opioid tolerance or hyperalgesia.
IMPLICATIONS: Intraoperative administration of tramadol, followed by nurse-controlled analgesia and background infusions, resulted in more rapid awakening from general anesthesia, less sedation, and earlier tracheal extubation than with morphine during the immediate postoperative period. After cardiac surgery tramadol provided equivalent analgesic efficacy and a comparable incidence of postoperative emesis as morphine in children <6 yr of age.
IMPLICATIONS: Hypothermia is a frequent concern when children are sedated for magnetic resonance imaging (MRI). In children sedated with chloral hydrate, we found that brain MRI scans can increase body temperature. Our results suggest that, in sedated children, absorption of radiofrequency radiation during MRI may offset heat loss resulting from the MRI environment.
IMPLICATIONS: Ultrasonographic guidance facilitated accurate placement of the needle for ilioinguinal/iliohypogastric nerve block in children and allowed titrating the smallest effective volume required for the block.
IMPLICATIONS: We obtained video images of the vocal cords of children through the perilaryngeal airway, a new supraglottic airway device, to assess its orientation in the upper airway. The epiglottis was folded over the vocal cords by the perilaryngeal airway in a large percentage of infants.
IMPLICATIONS: Anesthetic concentrations of propofol and thiopental, but not halothane, suppressed direct intercellular gap junction communication in cultured brain slices. Such suppression of gap junction function could compound the mechanisms of some anesthetics during their administration and withdrawal.
IMPLICATIONS: This study demonstrates that aging significantly increases the time required to induce anesthesia using an inhaledtechnique. Because inhaled induction is gaining popularity in adults, the clinician should be aware of this effect.
IMPLICATIONS: Halothane and isoflurane depress ciliary beat frequency directly and potently in isolated and cultured rat tracheal epithelial cells. Compared with halothane and isoflurane, sevoflurane has a much weaker ciliary beat frequency-depressant effect.
IMPLICATIONS: At halothane and isoflurane concentrations required to produce immobility, the cortex remains responsive to electrical microstimulation of the reticular formation, although the electroencephalographic response is depressed in the transition from 0.8 to 1.2 minimum alveolar concentration.
IMPLICATIONS: Although recent evidence has suggested the neuroprotective efficacy of xenon, the effects of xenon on motor evoked potentials remained undetermined. The results in the present study suggest that motor evoked potential recording may be feasible under xenon anesthesia if multipulse stimulation is used, although xenon has suppressive effects on myogenic motor evoked potentials.
IMPLICATIONS: We demonstrated that insulin protected against ischemic injury produced by 13 min of spinal cord ischemia in rabbits, whereas cyclosporin A alone failed to improve neurological and histopathological outcome.
IMPLICATIONS: Bupivacaine has higher anesthetic potency; however, the intra- to extracellular ratio of lidocaine was larger than that with bupivacaine when the nerve was blocked. These findings suggest that lidocaine required a larger intracellular concentration than bupivacaine to block nerve conduction in the giant axon of a crayfish in vitro.
IMPLICATIONS: Lidocaine significantly inhibits iNOS and CAT-2 and, in turn, enhances GTPCH expression in LPS-stimulated murine macrophages.
IMPLICATIONS: Response and state entropy are new parameters, calculated from spontaneous bioelectrical brain activity, which are mainly intended for measuring the hypnotic component of anesthesia. Electroencephalogram entropy was investigated for the first time in acupuncture research. Stimulation of specific acupuncture schemes produces specific reproducible and quantifiable responses in entropy.
IMPLICATIONS: Arterial occlusion pressure is a measure of the cuff pressure required to maintain a bloodless surgical field. We measured upper and lower extremity tissue pressures under the tourniquet cuff in 30 anesthetized living adult patients and developed an arterial occlusion pressure estimation method.
IMPLICATIONS: When alveoli collapse and reopen with each breath (tidal recruitment), Pao2 results obtained from arterial blood gases can vary markedly depending on when the sample was obtained during the respiratory cycle. Interpretation of Pao2 results without accounting for respiratory Pao2 oscillations could lead to erroneous conclusions about the impact of ventilator adjustments on shunt fraction and atelectasis.
IMPLICATIONS: Paravertebral transcutaneous electrical nerve stimulation was evaluated as a means of enhancing anesthesia during hysterectomy. The significant decrease in limb movements found with this surface electrical stimulation method suggests that this noninvasive procedure deserves further exploration for its clinical usefulness and mechanism of action.
IMPLICATIONS: Oxycodone, methadone, and especially l-methadone were more effective than morphine in all studied pain models in the rat, including a model of nerve injury pain. Morphine may not be the most effective opioid, whereas l-methadone could be an interesting option when treating neuropathic pain.
IMPLICATIONS: Stimulation of the craniospinal nerves mediates the antinociceptive effect of transcranial electrostimulation in a rat through activation of a variety of endogenous antinociceptive systems.
IMPLICATIONS: In a rat model, a synthetic polyamine-deficient diet alone can induce a significant analgesic effect on an inflammatory pain induced by carrageenan injection in a paw. The analgesic mechanism remains unclear, but it was totally reversed by a subcutaneous injection of naloxone and partly reversed by a subcutaneous injection of ketamine. A simple synthetic polyamine-deficient diet could reduce hypersensitivity to pain in the postoperative period.
IMPLICATIONS: We report an unrecognized data transmission loss while using an automated anesthesia record keeping system. A documentation window concealed the home screen window, which displayed graphical vital sign data. Absence of vital signs on the printed anesthesia record, and a bad surgical outcome, increased our medical liability exposure.
IMPLICATIONS: In volunteers with full stomachs subjected to acute pain, erythromycin is effective as a prokinetic drug on the gastric emptying rate for solids. Its administration could be useful before emergency anesthesia in nonfasting patients with pain to prevent the risk of pulmonary aspiration of gastric contents.
IMPLICATIONS: This prospective observational study demonstrates that in critically ill patients, a hospital-admission NT-pro-BNP level more than 1900 pg/mL predicts mortality independent of a APACHE II score, with the higher NT-pro-BNP levels predicting more frequent mortality.
IMPLICATIONS: The intracarotid bolus dose propofol required to maintain electroencephalographic silence was one third of the continuous infusion dose and was directly related to the amount (mg/bolus) in each bolus. However, maximum regional effects will require titration of bolus characteristics.
IMPLICATIONS: Indomethacin rapidly reduces intracranial pressure (ICP) during both isoflurane and propofol anesthesia, with the effect on ICP being most pronounced during isoflurane. This observation may have relevance for the treatment of high ICP during brain tumor surgery in patients anesthetized with isoflurane or propofol.
IMPLICATIONS: We investigated the effect of desflurane and sevoflurane on cerebral oxygenation (rSO2) for bispectral index (BIS) values of 40-50 and 20-30. For the same BIS values the rSO2 was similar for both anesthetics but for the same anesthetic a lower BIS was associated with higher rSO2 values.
IMPLICATIONS: We demonstrated that the motor blockade EC50 of epidural ropivacaine was 0.383% (95% confidence interval, 0.358%-0.409%) in elderly patients and 0.536% (95% confidence interval, 0.512%-0.556%) in young patients. This indicates that age is a determinant of motor blockade EC50 of ropivacaine with epidural administration.
IMPLICATIONS: One percent lidocaine prepared by dilution of 2% lidocaine with an equal volume of saline was less potent with regard to sensory blockade when compared with plain 1% lidocaine.
IMPLICATIONS: A conventional midhumeral block was compared with a 2-injection axillary brachial plexus block performed in an emergency context. The success rate was similar between approaches. However, onset time was faster and patient acceptance was greater with the axillary approach. The axillary technique is superior for emergency hand surgery.
IMPLICATIONS: In 40 cadaver femoral triangle dissections, the lateral circumflex femoral artery, a branch of the femoral artery, was exposed and its position measured. In 50% of the specimens, this artery lay within 1 cm, proximal or distal, of the inguinal crease. Awareness of this anatomy may reduce the risk of intravascular injection during femoral nerve blockade.
IMPLICATIONS: We report the case of a patient with motor and sensitive disorder of both legs accompanied with sphincter deficiency and loss of hearing. This association has been never reported.
IMPLICATIONS: We report a case of diplopia at distance, divergence paresis, which developed after uneventful spinal anesthesia. Although cranial magnetic resonance imaging findings were consistent with cerebrospinal fluid hypovolemia, the patient had no positional headache. Our case suggests that gadolinium-enhanced magnetic resonance imaging may be useful when a patient develops neurologic symptoms after dural puncture.
IMPLICATIONS: The accuracy of the original and modified versions of the Mallampati test ranges from poor to good for predicting difficult laryngoscopy and difficult intubation. The Mallampati tests have limited accuracy for predicting the difficult airway and thus are not useful screening tests when used alone.
IMPLICATIONS: Manual dexterity is improved when subjects are seated in a comfortable position compared to kneeling or standing bent forward at the waist.
To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.