A Comparison of Three Phosphodiesterase Type III Inhibitors on Mechanical and Metabolic Function in Guinea Pig Isolated Hearts
Anesth Analg 2006 102: 1646-1652.
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IMPLICATIONS: In the isolated Langendorff heart, amrinone, enoximone, and milrinone dose-dependently produced positive chronotropic, inotropic, and lusitropic effects, although only enoximone and milrinone increased oxygen consumption. Coronary flow reserve was preserved by each drug, indicating an intact coronary autoregulation. In addition, these tested phosphodiesterase inhibitors do not directly cause coronary vasodilation.