The Effects of Volatile Anesthetics on Spontaneous Contractility of Isolated Human Pregnant Uterine Muscle: A Comparison Among Sevoflurane, Desflurane, Isoflurane, and Halothane
Anesth Analg 2006 103: 443-447.
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IMPLICATIONS: Volatile anesthetics, including sevoflurane, desflurane, isoflurane, and halothane, inhibit spontaneous contractility of gravid human uterine muscle in a dose-dependent manner. These effects are unlikely to be related to modulation of BKCa or KATP channels, except for the action of isoflurane, which is in part mediated through activation of KATP channels.