The Differential Effects of Halothane and Isoflurane on Windup of Dorsal Horn Neurons Selected in Unanesthetized Decerebrated Rats
Anesth Analg 2006 103: 753-760.
[Abstract]
[Full Text]
[PDF]
IMPLICATIONS: Halothane and isoflurane dose-dependently inhibited dorsal horn neuronal windup in the 0-0.8 minimum alveolar anesthetic concentration (MAC) range, consistent with their ability to reduce temporal summation for pain. Halothane, but not isoflurane, further depressed windup at 1.2 MAC, suggesting different sites of immobilizing action for these anesthetics.