IMPLICATIONS: The impact of gender on outcomes after aortic valve replacement is controversial. The results of this retrospective investigation find that female gender does not impart a greater than 2.5-fold increase in risk of postoperative mortality after aortic valve replacement. Female gender may impart increased risk for postoperative cardiac morbidity.
IMPLICATIONS: Surgery and cardiopulmonary bypass lead to a potent stress response which might be associated with an imbalance of the immune system and increased risk for postoperative infections. Clonidine might attenuate this stress response by reducing the sympathetic tone and consecutively reducing immune cell activation maintaining immune balance after surgery.
IMPLICATIONS: Fentanyl induces cardioprotection against ischemia/reperfusion (I/R) injury associated with sympathetic overactivity in rabbits. This cardioprotective effect of fentanyl is essentially characterized by central antiarrhythmic and peripheral antiischemic actions and confirms the importance of opioid drug use for managing patients with ischemic heart disease submitted to anesthesia and surgery.
IMPLICATIONS: The selective {kappa}-opioid receptor antagonist nor-binaltorphimine increases regional and global myocardial contractility and improves recovery from myocardial stunning after regional myocardial ischemia in chronically instrumented dogs. This suggests that selective {kappa}-opioid receptor antagonism may have the potential to protect patients at high risk of myocardial ischemia-reperfusion injury.
IMPLICATIONS: Even with infrarenal cross-clamping of the aorta, renal preservation and hemodynamic stability are vital. We compared fenoldopam with a combination of dopamine and nitroprusside and found no superiority regarding hemodynamic maintenance or renal protection. With current economic pressures, selection of equivalent therapies may result in cost savings.
IMPLICATIONS: Tissue factor pathway inhibitor (TFPI), the endogenous inhibitor of tissue factor-initiated coagulation, could potentially affect thrombelastographic variables. The concentrations of TFPI required to affect thrombelastographic variables exceeded by >=80-fold normal concentrations. Thus, clinically encountered TFPI concentrations would be expected to have minimal effects on thrombelastographic assessments of hemostasis.
IMPLICATIONS: We validated a method of quantifying the impact of regional myocardial ischemia on global cardiac performance using regional phase angle analysis easily applied at the bedside.
IMPLICATIONS: Patients who have had complex cardiac surgery as children are now presenting as adults requiring anesthesia. We explored the implications of neonatal cardiac surgery and Fontan physiology in a young adult undergoing laparoscopic surgery.
IMPLICATIONS: A sedation and anesthesia program for infants that includes oral chloral hydrate, IV pentobarbital, and propofol infusion can meet the sedation and anesthesia requirements to obtain magnetic resonance imaging (MRI) studies. Infants who received pentobarbital and propofol were less likely to be inadequately sedated for MRI, but they more frequently experienced a cardiorespiratory event when compared to infants who received chloral hydrate.
IMPLICATIONS: We conducted a retrospective study to examine risk factors for intraoperative hypotension (IH) during emergent decompressive craniotomy. Of the risk factors examined, midline shift on head computed tomography and blood loss predicted IH but midline shift >=4 mm predicted IH, independent of IH.
IMPLICATIONS: These experiments showed that epidural lidocaine caused dose-dependent functional impairment and histologic damage after continuous infusion in rats. The findings suggest that patients may not be immune to neurologic injury when epidural lidocaine is administered in large doses.
IMPLICATIONS: A clear, colorless microemulsion or an opaque macroemulsion of propofol was used to induce anesthesia in dogs and did not significantly vary with respect to dose, time to induction and recovery, vital signs, hemogram, coagulation time, or plasma propofol concentrations from one preparation to the other.
Implications: We describe a novel, automated, noninvasive, model-based approach to detect inadvertent endobronchial intubation within seconds of onset using airway pressure and flow signals.
IMPLICATIONS: We performed a discriminant function analysis on single and combined information extracted from simultaneous measurements of electroencephalogram, auditory evoked potentials, and somatosensory evoked potentials as predictors of four different states during clinical anesthesia. Combined information from these electrophysiological measurements showed more discriminant power than information from each measurement alone.
IMPLICATIONS: Although there is evidence of a quantitative interaction of propofol with remifentanil for unconsciousness, increasing concentrations of remifentanil are not adequately reflected in the assessment of anesthesia based on middle latency auditory evoked potentials during propofol anesthesia. Therefore, remifentanil does seem to have only a limited contribution to the suppression of the auditory evoked response.
IMPLICATIONS: Assuring reliable, timely administration of prophylactic antibiotics before elective surgery is difficult. Using an electronic documentation system and practice guidelines to provide feedback to individual anesthesia providers significantly increased the proportion of patients receiving antibiotics within 60 min of incision for all types of surgery. This methodology lends itself to application with additional performance measures, such as blood glucose and normothermia management.
IMPLICATIONS: A negative-pressure operating theater may help limit the spread of air-borne infections from patients with respiratory disease. This article describes the ventilation design of a specific case and evaluates its airflow performance using computer simulation.
IMPLICATIONS: There is significant variation in anesthesia release time and surgical preparation time. For operating room scheduling purposes, assigning a constant fixed duration for anesthetic induction is inappropriate and will result in creating erroneous administrative expectations.
IMPLICATIONS: Anesthesia release time in young children undergoing surgery is highly variable and is dependent on factors such as the surgical service involved, ASA physical status, age, and placement of invasive hemodynamic monitors. These factors should be considered when scheduling a surgical case.
IMPLICATIONS: Although anesthesiology resident teaching during the preincision period increases time to surgical incision, the increase is minor and insignificant compared with the time required to complete the surgical procedure.
IMPLICATIONS: For a large group of patients, attending anesthesiologists perform well in predicting the time required before releasing a patient to the surgical team after induction of anesthesia. However, for a given patient the accuracy is only 53%.
IMPLICATIONS: Perioperative pulmonary aspiration (PPA) occurred in 14 of 99,441 anesthetics at our teaching hospital over 4 yr, with 70% of PPA attributed to improper anesthesia technique. Identifying patients at risk for PPA and the surgical procedures that put them at risk will provide a better choice of anesthetic technique to prevent this serious complication.
Implications: As hemorrhagic shock can result in global cerebral ischemia, markers of cerebral metabolism and cell damage may be useful in evaluating therapy strategies. Intracerebral microdialysis is a sensitive, established technique which can be used to analyze tissue biochemistry.
IMPLICATION: The use of dexmedetomidine as a primary sedative does not increase intraarterial shunting in patients undergoing awake carotid endarterectomy as compared to historical control.
IMPLICATIONS: A suprasternal Doppler technique was used to measure cardiac output after either standard or sequential combined spinal-epidural anesthesia for elective cesarean delivery. No difference in cardiovascular stability was found as a result of anesthetic technique in healthy parturients.
IMPLICATIONS: We studied the incidence of intubation difficulty in 324 consecutive patients scheduled for thyroid surgery. The presence of a palpable goiter, airway deviation, or airway compression did not predict difficult intubation.
IMPLICATIONS: The aim of this laboratory investigation was to study the influence of different thawing procedures on the activity of clotting factors and inhibitors of the hemostatic system. The results may influence clinical practice, as the results between the commercially available devices and the control method were not different.
IMPLICATIONS: We report a case of malignant hyperthermia (MH) in China and suggest that dantrolene be routinely stocked throughout China for treatment of MH.
IMPLICATIONS: In the hyperlordotic position, the patient's hips are above the feet and head. This position facilitates abdominal surgery but can also cause organ damage. We report a case of liver failure after a prostatectomy performed in the hyperlordotic position. This position should only be used with careful monitoring of organ function.
IMPLICATIONS: This prospective, randomized, double-blind study demonstrated that intrathecal morphine (0.5 mg) and fentanyl (15 {micro}g) given before liver surgery significantly decreased postoperative morphine consumption, without any increase in side effects, compared to placebo.
IMPLICATIONS: The incidence of chronic postsurgical pain (CPSP) was 80% versus 0% in the standard and aggressive pain management groups, respectively. Adequacy of postoperative analgesia is an important determinant of CPSP after breast surgery. No association between perioperative plasma concentrations of stable nitric oxide products and subsequent development of CPSP was found.
IMPLICATIONS: Although a minor complication, postoperative sore throat contributes to postoperative morbidity and patient dissatisfaction. Preoperative gargling with dispersible aspirin (completely dissolved in water before taking) and preoperative gargling with benzydamine hydrochloride reduce both the incidence and the severity of postoperative sore throat.
Implications: In a rabbit nociceptive pain model, the antinociceptive effect of IV remifentanil was rapid in onset and brief in duration. In the same model, the antinociceptive effect of adenosine was slow in onset, but lasted many hours after termination of the infusion, despite the ultrashort plasma half-life of adenosine.
IMPLICATIONS: We explored whether the presence of the A118G single nucleotide polymorphism (SNP) of the human mu opioid receptor (MOR) gene could explain inter-individual differences in opioid analgesic requirements between surgical acute postoperative pain and chronic pain patients. Although the presence of the minor allele (G118 MOR) does not appear to affect morphine requirements in the acute postoperative pain patients, the minor allele is less common in chronic pain patients, especially in those requiring high-dose opioids.
IMPLICATIONS: Elective total hip replacement under neuraxial block has a lower incidence of blood transfusion, deep venous thrombosis, and thromboembolic events than that under general anesthesia. Neuraxial block also reduces the operative time by 7.1 min/case and intraoperative blood loss by 275 mL/case.
IMPLICATIONS: In this study we prospectively performed a computed tomography (CT) epidurography whenever the etiology of an epidural analgesia failure was not obvious and compared it to CT data of an equivalent number of patients having successful analgesia. The major cause of failure was secondary dislodgement.
IMPLICATIONS: Using ultrasonography may improve the success and reduce the rate of complications when performing cryoanalgesia of intercostal nerves for postthoracotomy pain.
IMPLICATIONS: We report three cases of bleeding associated with femoral and sciatic nerve catheters and enoxaparin thromboprophylaxis. More data are required to determine optimal management guidelines of peripheral, relative to neuraxial, catheters.
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