IMPLICATIONS: In 8281 cardiac surgical patients, we retrospectively tested the hypothesis that higher doses of aprotinin may be more effective in reducing bleeding and transfusion requirements compared to lower doses. In a dose-dependent manner, aprotinin reduced postoperative chest tube drainage, transfusion requirement, and the incidence of rethoracotomy, while there was no detrimental effect on renal function.
IMPLICATIONS: We sought to determine if large-dose aprotinin therapy had any benefit to patients having myocardial revascularization other than reduction in transfusion. Analysis of a database of 1723 patients participating in randomized, blinded, placebo-controlled studies showed that, in patients when given this therapy, stroke and need for therapy to maintain cardiovascular stability were significantly less.
IMPLICATIONS: Perfluorocarbon administration significantly reduced the volume of bubbles within the cardiopulmonary bypass (CPB) circuit, suggesting that it may be advantageous for reducing bubble-associated damage during CPB.
IMPLICATIONS: Levosimendan is a potent, endothelium-independent, direct vasodilator of the internal mammary artery (IMA). These in vitro data suggest that levosimendan might be a useful drug for the inhibition of IMA vasospasm in myocardial revascularization surgery.
IMPLICATIONS: Preoperative fasting before major surgery is detrimental to patients' pre- and postoperative well-being and increases postoperative insulin resistance. Clear fluid intake (400 mL) 2 h before surgery reduced thirst without increasing gastric fluid volume. Oral administration of carbohydrate-rich beverages did not affect insulin resistance, but was associated with intraoperative reduced inotropic requirements after initiation of cardiopulmonary bypass weaning until end of operation.
IMPLICATIONS: Atrial fibrillation after coronary artery surgery prolongs hospital stay and complicates care. Predicting this outcome would allow targeted prophylaxis. Heart rate variability measures in this study indicate that peak point correlation dimension (PD2), a nonlinear measure, best associates with cardiac arrhythmias, warranting further investigation.
IMPLICATIONS: This case report describes failed defibrillation during robot-assisted internal mammary harvesting during coronary artery bypass surgery. A discussion of pertinent factors that affect successful defibrillation and resuscitation during robot-assisted thoracic surgery follows the case report.
IMPLICATIONS: Adenotonsillectomy is a common surgical therapy for obstructive sleep apnea syndrome (OSAS) in children. This prospective study identifies perioperative complications and the risk factors associated with adenotonsillectomy in children with OSAS. Children with OSAS have a higher rate of complications after adenotonsillectomy than children undergoing the procedure for recurrent adenotonsillitis.
IMPLICATIONS: There is enough space in the retromolar region for endotracheal tube placement in children. Retromolar intubation can be used in children during surgery when intraoperative maxillomandibular fixation, and simultaneous access to the nose and oral cavity are required.
IMPLICATIONS: Acoustic reflectometry profiles of the pediatric airway and esophagus were studied in children, aged 2-12 yr, intubated with endotracheal tubes (ETT) of 4.5-6 mm inner diameter (ID) The characteristic tracheal, esophageal, and bronchial profiles seen in adults were likewise seen in these pediatric patients. A case of possible ETT abutment against a bronchial wall, and its acoustic reflectometry detection, is discussed.
IMPLICATIONS: Antithrombin III-deficient neonates presenting for cardiac surgery have lower than expected levels of {alpha}2M, a significant inhibitor of thrombin during the neonatal period. Our data raise concern about the ability to adequately anticoagulate these neonates during cardiopulmonary bypass and question the meaning of the prolonged activated clotting times values often seen in these children.
IMPLICATIONS: This prospective study of infants undergoing an arterial switch operation used echocardiography to detect myocardial motion abnormalities after repair. Infants with multiple abnormal myocardial segments had greater biochemical and electrocardiographic evidence of ischemia in the immediate postoperative period. This shows that segmental wall motion abnormalities after an arterial switch operation may be associated with ischemia.
IMPLICATIONS: We find that smokers do not differ in unwanted respiratory responses (coughing, breath holding, or laryngospasm) during delivery of anesthesia with desflurane versus sevoflurane, via a laryngeal mask airway. A retrospective comparison of these results with those from our previous study of 100 nonsmokers demonstrates that smoking, but not anesthetic choice, increases the incidence of unwanted respiratory responses.
IMPLICATIONS: In patients undergoing gynecologic laparoscopic procedures, the combination of ondansetron 4 mg IV and droperidol 1.25 mg IV produced an additive effect for preventing postoperative nausea and vomiting. The observed change in the QTc interval was small and not increased by the combination when compared with each drug was given separately.
IMPLICATIONS: Long-latency auditory-evoked potentials provide evidence of persistent cortical processing in volunteers sedated with a combination of dex/remi compared to mida/remi at the same clinical sedation levels. Electrophysiologic methods for monitoring sedation should be applied in the context of the sedative drugs used.
IMPLICATIONS: Glomerular and tubular functions were transiently affected in elderly patients after orthopedic surgery. A transient decrease of creatinine clearance was observed during the first 2 h after the initial dose of parecoxib, but the differences between the treatment groups were small and not clinically relevant.
IMPLICATIONS: Because we found that droperidol administration, and thus blockade of D2 dopamine receptors, does not alter MAC for several conventional inhaled anesthetics or for etomidate, we conclude that dopamine receptors do not mediate the capacity of inhaled anesthetics to produce immobility in the face of noxious stimulation.
IMPLICATIONS: Photoplethysmographic heart rate variation in response to positive pressure ventilation was related to pulse pressure variation in the arterial pressure waveform. Because pulse pressure variation can predict fluid responsiveness, photoplethysmography could be used as a noninvasive predictor of fluid responsiveness.
IMPLICATIONS: In this study, the performance of bispectral index XP and auditory-evoked potential monitors were assessed during light-to-moderate propofol-induced sedation for ophthalmic surgery in 100 patients.
IMPLICATIONS: This study shows that the use of cadavers in anesthesiology training improves the confidence of residents in using percutaneous cricothyrotomy and retrograde intubation.
IMPLICATIONS: Fewer women are enrolled in anesthesiology training programs than in those in other specialties. Women may shun anesthesiology residencies because of the lack of women role models, gender discrimination, misperceptions of the physician-patient relationship in anesthesiology, and inflexible practice scheduling requirements.
IMPLICATIONS: Transtracheal gas insufflation (TGI) improves gas exchange but causes hyperinflation. We showed that a new and simple bidirectional TGI and flow compensation system improves gas exchange efficiency and prevents hyperinflation.
IMPLICATIONS: In a prospective observational study of adult intensive care unit admissions with acute respiratory failure (ARF), mortality was related more to the presence of multiple organ failure than to initial lung function. Initial and delayed onset ARF have different patterns of associated organ dysfunction, and the monitoring of nonpulmonary organ function may be useful in assessing outcome.
IMPLICATIONS: Implantation of deep brain stimulators (DBS) is an accepted treatment for patients with advanced Parkinson's disease. The anesthetic management of these procedures is challenging because sedative and anesthetic drugs may interfere with electrophysiologic monitoring. Sedation with the {alpha}-2 agonist, dexmedetomidine, in DBS implantations may be advantageous, allowing for better blood pressure control without interfering with microelectrode recording.
IMPLICATIONS: The estimated specific gravity of the overall intracranial content and of noncontused hemispheric areas derived from computed tomography DICOM images is a marker of the severity of brain injury in the first 24 h after severe traumatic brain injury in humans.
IMPLICATIONS: Scalp nerve block provides transitional analgesia that is equivalent to morphine after remifentanil-based anesthesia in patients undergoing supratentorial craniotomy.
IMPLICATIONS: QTc interval may be prolonged in women with severe preeclampsia because of hypertension and hypocalcemia. Spinal anesthesia may normalize prolonged QTc intervals due to sympathetic blockade.
IMPLICATIONS: The modified Mallampati examination is a standard method of predicting difficult laryngoscopy. We report that performing this examination with the patient in craniocervical extension decreases the classification scores and improves both specificity and positive predictive value.
IMPLICATIONS: The 20{degrees} reverse-Trendelenburg position effectively ameliorates postoperative nausea or vomiting in patients undergoing thyroid surgery.
IMPLICATIONS: The practitioner responsible for emergency intubation must have a strategy to manage the failure of conventional intubation methods as well as a backup accessory device when other advanced airway devices fail.
IMPLICATIONS: Maxillomandibular advancement (MMA) surgery is increasingly used as a surgical option in the treatment of obstructive sleep apnea. We report a case of life-threatening airway obstruction after MMA and discuss the etiology of airway compromise after these surgeries.
IMPLICATIONS: The perioperative administration of a combination of celecoxib and pregabalin improved analgesia and caused fewer side effects than either analgesic drug alone after spinal fusion surgery.
IMPLICATIONS: A single dose of 800 mg of oral gabapentin did not prolong recovery or cause apparent side effects. It may thus have a role in ambulatory surgery. However, this dose of gabapentin did not augment postoperative analgesia in patients with interscalene nerve blocks.
IMPLICATIONS: Although animal studies suggest pregnancy-induced antinociceptive effects, human studies are conflicting and often lack a nonpregnant control group. We determined the sensitivity to experimental pain in pregnant and nonpregnant women and found pregnancy-induced analgesic effects to heat pain.
IMPLICATIONS: Pain after gynecologic surgery has both somatic and visceral components. We describe a new model of postoperative pain in rodents in which these can be distinguished and selectively studied so as to improve treatment of pain after gynecologic surgery.
IMPLICATIONS: Patients with preexisting neural compromise may be at an increased risk of further neurologic injury after neuraxial anesthesia or analgesia. This retrospective review found the risk of severe postoperative neurologic dysfunction in patients with a stable peripheral sensorimotor neuropathy undergoing neuraxial anesthesia or analgesia to be 0.4% (95% CI 0.1%-1.3%). Although this rate represents a relatively uncommon event, the risk appears to be higher than that reported for the general population.
IMPLICATIONS: Nerve-stimulator-guided needle placement improves the success and decreases the latency for posterior tibial nerve block at the distal site. A proximal block site 7 cm above the medial malleolus is an alternative to the traditional distal approach particularly in patients with restricted access to the distal site.
IMPLICATIONS: Lumbosacral cerebrospinal fluid (CSF) volume, a factor in the clinical response to spinal anesthesia, is widely variable among patients. Using a three-dimensional magnetic resonance image and computer postprocessing technique, we found that lumbosacral CSF volume is inversely proportional to body mass index and decreased in patients with radiographic diagnoses of spinal stenosis.
IMPLICATIONS: Epidural analgesia with ropivacaine provided significantly better analgesia and higher patient satisfaction than IV analgesia with morphine after major spine surgery.
IMPLICATIONS: There are differences in epidural pressure between the low-thoracic and mid-thoracic epidural space. The influence on the distribution of local anesthetic and sensory blockade in thoracic epidural anesthesia remains undetermined.
IMPLICATIONS: Among 91 survey respondents, there appears to be no consensus as to how best to prepare for the rare episode of local anesthetic cardiac toxicity, or how to optimally manage such a catastrophe.
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