IMPLICATIONS: A survey of members of the Society of Cardiovascular Anesthesiologists indicates that ultrasound use to guide placement of central venous catheters is not routinely used in clinical practice, despite recent patient safety recommendations.
IMPLICATIONS: Animal studies suggest that neurodegeneration, with possible cognitive sequelae, is a potential long-term risk of anesthetics in neonatal and young pediatric patients. There are no data to support recommending that any anesthetic or regimen is safer than any other. The Food and Drug Administration anticipates working with the anesthesia community and pharmaceutical industry to develop strategies for further assessing the safety of anesthetics in neonates and young children, and for providing data to guide clinicians in making the most informed decisions possible.
IMPLICATIONS: Children with suprasystemic pulmonary hypertension have a significant risk of life-threatening complications when they undergo general anesthesia or sedation for noncardiac surgery or cardiac catheterization.
IMPLICATIONS: Laryngeal mask airway removal may be accomplished without coughing, moving, or any other airway complication at 1.84% end-tidal sevoflurane concentration in 50% of anesthetized children.
IMPLICATIONS: This study demonstrates that the addition of clonidine to ropivacaine or bupivacaine increases the duration of the sensory component of a peripheral block in children, but that it also increases motor component as well.
IMPLICATIONS: We documented the hemostatic changes associated with placement of a EXCOR(R) Berlin Heart left ventricular assist device in a 15-month-old child before heart transplantation. When managing patients with a Berlin Heart, consideration of hypercoagulable features and anticoagulant therapy must be made to maximize patient safety.
IMPLICATIONS: Auricular acupuncture, with or without electrostimulation, did not affect postoperative pain or analgesic drug consumption within the first 48 h after mandibular third molar tooth extraction in a randomized, double-blind, placebo-controlled trial.
IMPLICATIONS: In a retrospective database analysis, promethazine was significantly more effective than a repeat dose of ondansetron for the treatment of established postoperative nausea and vomiting (PONV) in the postanesthesia care unit in patients who received PONV prophylaxis with ondansetron.
IMPLICATIONS: Four intrathecal anesthetic techniques were compared among elderly people (>=65 yr) undergoing short transurethral procedures. Of the doses investigated, bupivacaine 4 mg plus fentanyl 20 {micro}g, was associated with adequate analgesia, hemodynamic stability and favorable recovery.
IMPLICATIONS: This study examined the safety, dosing, and efficacy of the first selective relaxant binding agent, sugammadex. Sugammadex can safely and quickly reverse a profound rocuronium-induced, neuromuscular block. The drug was well tolerated by all subjects. The speed of complete recovery (T4/T1ratio of 0.9) was dose dependent. A dose of 2 mg/kg of sugammadex consistently produced complete recovery from deep neuromuscular block.
IMPLICATIONS: Sevoflurane enhances the effects of neuromuscular blocking drugs. This study clearly demonstrates that the novel reversal drug, sugammadex, 2 mg/kg, administered at reappearance of T2, was equally effective at reversing rocuronium-induced neuromuscular block in anesthetized patients maintained on propofol or sevoflurane anesthesia.
IMPLICATIONS: Use of the cyclodextrin reversal drug, sugammadex, (4 mg/kg IV) was associated with a more rapid reversal of the train-of-four (TOF) to 0.9 after rocuronium-induced neuromuscular blockade (107 {+/-} 61 s) when compared with edrophonium (331 {+/-} 27 s) or neostigmine (1044 {+/-} 590 s). More importantly, 75% of the patients in the sugammadex group achieved a TOF of 0.9 at 2 min after reversal compared with none in the two anticholinesterase groups. Sugammadex was also associated with less dry mouth than that with the conventional reversal drug combinations in the early postoperative period.
IMPLICATIONS: This article addresses the unique characteristics of sugammadex and describes how this drug is likely to change anesthesia practice.
IMPLICATIONS: A temporary decrease in twitch response was observed during reversal of rocuronium-induced muscle relaxation with a small dose of sugammadex. Pharmacokinetic-pharmacodynamic model simulations indicate that redistribution may play a role, and that a sufficiently large dose of sugammadex prevents muscle relaxation rebound.
IMPLICATIONS: Sugammadex (350 mg IV) rapidly reversed acute respiratory distress in the postanesthesia care unit due to vecuronium-related residual neuromuscular blockade in a renal failure patient who was inadequately reversed with a maximal dose (5 mg IV) of neostigmine.
IMPLICATIONS: Emergence time after isoflurane anesthesia was shortened by 59% when hyperventilation rapidly removed anesthetic from the lungs and hypercapnia increased cerebral bloodflow. Hypercapnic hyperventilation should be considered when rapid emergence after isoflurane anesthesia is important.
IMPLICATIONS: Automatic electronic reminders generated by an anesthesia information system can improve procedure documentation and lead to a more complete record as well as increased reimbursement.
IMPLICATIONS: Functional residual capacity (FRC) measurement by the oxygen washout method in healthy spontaneously breathing volunteers has an acceptable bias when compared with FRC measurements using helium dilution and body plethysmography, although limits of agreement could be improved.
IMPLICATIONS: We compared the cerebral state monitor with the bispectral index (BIS) during propofol anesthesia. The cerebral state index (CSI) stabilized at 60-40 when the propofol concentration increased from 5 to 8 {micro}g/mL. The BIS stabilized at 40-20 when the propofol concentration increased from 7 to 10 {micro}g/mL. This suggests that BIS may be a more useful index for evaluating intermediate anesthetic levels, whereas CSI may be better for evaluating deeper anesthetic levels.
IMPLICATIONS: Using magnetic resonance imaging of the airway for comparison, this study demonstrates the potential utility of ultrasound to easily measure transverse airway diameter.
IMPLICATIONS: Preanesthesia evaluation clinics are a common component of hospital institutions, but information obtained during the presurgical visit may not be available on the day of surgery. As a result, missing patient information may continue to cause delays on the day of surgery.
IMPLICATIONS: The incidence of unrecognized out-of-hospital esophageal intubation is frequent when end-tidal CO2 monitoring and esophageal detection devices are not used for tube placement confirmation by emergency medical service physicians with basic training. Unrecognized esophageal intubation is associated with a high mortality rate.
IMPLICATIONS: Synthetic colloids are widely used to preserve normal intravascular volume in septic patients. There is debate, however, over which synthetic colloid to be used. In this rat model of sepsis induced by cecal ligation and puncture, hydroxyethyl starch inhibited inflammatory mediators and neutrophil infiltration, whereas modified fluid gelatin did not. Although the results cannot be directly extrapolated to the clinical setting, they encourage further research in patients.
IMPLICATIONS: Sevoflurane improves lung mechanics and reduces airway and tissue resistance in experimental chronic allergic asthma. These results, if confirmed in patients, can help to optimize the perioperative management of asthma patients.
IMPLICATIONS: Sevoflurane pretreatment attenuates acute experimental lung injury by reducing the production of inflammatory mediators. The effects of inhaled sevoflurane on lung inflammation in patients should be evaluated.
IMPLICATIONS: ST36 acupuncture pretreatment significantly attenuates sepsis-induced kidney, but not liver, injury in rats, whereas ST36 acupuncture performed after sepsis induction has no protective effects against sepsis-induced organ injuries.
IMPLICATIONS: High pressures exerted by the cuffs of endobronchial devices may reduce mucosal blood flow, leading to mucosal injury. This study shows that at clinical cuff volumes, the pressures exerted by the cuffs do not exceed the recommended safe limit.
IMPLICATIONS: In rabbits under pentobarbital anesthesia, abdominal aortic unclamping (after a 20-min clamp) induced a sustained pial arteriolar constriction (both large and small vessels) that was attenuated by IV nicardipine (1.0 and 10 {micro}g{middle dot}kg-1{middle dot}min-1) without hypotensive effects, whereas prostaglandin E1 was ineffective.
IMPLICATIONS: The efficacy of intraoperative red blood cell salvage in reducing allogenic transfusions in obstetric cases is unknown. Our results provide new insight into the number of cesarean delivery patients who might benefit from salvaged red blood cells and the potential utility of this technology.
IMPLICATIONS: This study showed that instead of a basal continuous infusion, automated regular boluses could be synchronized with patient-controlled epidural analgesia to reduce drug consumption for laboring women.
IMPLICATIONS: This randomized, double-blind, placebo-controlled trial evaluated the efficacy of granisetron for the prevention of nausea and vomiting during cesarean delivery under spinal anesthesia. The incidence of intraoperative nausea and vomiting was 20.4% in the granisetron group and 17% in the control group. Despite strict control of causative factors, prophylactic granisetron 1 mg was found to be ineffective.
IMPLICATIONS: This study describes the impact of suctioning on blood collected for cell salvage, and describes a method for minimizing suction damage.
IMPLICATIONS: Overall, there is insufficient evidence to confirm or deny the ability of postoperative analgesic techniques to affect major postoperative mortality or morbidity. This is primarily due to typically insufficient subject numbers to detect differences in currently low incidences of postoperative complications.
IMPLICATIONS: The pharmacologic nature of the interaction between intrathecal cannabinoid receptor agonist (WIN 55,212-2) and bupivacaine was determined using the formalin test. Intrathecally coadministered WIN 55,212-2 and bupivacaine produced synergistic antinociceptive interaction in both phases of the formalin test, with decreased side effects such as sedation and motor impairment.
IMPLICATIONS: In rats intrathecal morphine infusions downregulate production of glutamate dehydrogenase and glutamate synthetase. Concurrent administration of intrathecal dexamethasone attenuates this downregulation.
IMPLICATIONS: Bilateral ilioinguinal block with ropivacaine and clonidine significantly decreases total morphine consumption during the first 48 h after hysterectomy or prolapse repair. However, it does not decrease the side effects of morphine.
IMPLICATIONS: We describe a case of inadvertent right-sided interpleural catheter placement and pneumothorax during attempted epidural catheter placement for left-sided rib fractures that went unrecognized because of bilateral blockade and adequate analgesia.
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