Anesth Analg 2007 104: 624-630.
[Abstract]
[Full Text]
[PDF]
IMPLICATIONS: Synthetic colloids are widely used to preserve normal intravascular volume in septic patients. There is debate, however, over which synthetic colloid to be used. In this rat model of sepsis induced by cecal ligation and puncture, hydroxyethyl starch inhibited inflammatory mediators and neutrophil infiltration, whereas modified fluid gelatin did not. Although the results cannot be directly extrapolated to the clinical setting, they encourage further research in patients.