Anesth Analg 2007 104: 927-935.
[Abstract]
[Full Text]
[PDF]
IMPLICATIONS: Local, but not systemic, administration of nonsteroidal antiinflammatory drugs (NSAIDs) produces antinociception in the tail-flick thermal assay. The endogenous opioid system contributes to the peripheral antinociceptive effects of dipyrone, but not to that of diclofenac, ketorolac, lysine asetyl salicylate, or sodium salicylate, suggesting differences in the mechanisms of action among the NSAIDs.