IMPLICATIONS: During cardiac surgery for carcinoid heart disease, octreotide administration blunted the carcinoid-trigger effects of vasoactive medications. Octreotide also masked any theoretical advantages of aprotinin in controlling carcinoid symptoms.
IMPLICATIONS: Xenon reduced the size of myocardial infarction when administered during acute ischemia and reperfusion. The myocardial protective effects of xenon, though, are less than those observed with ischemic preconditioning.
IMPLICATIONS: In isolated perfused rat hearts, isoflurane preconditioning was found to preserve Ca2+ cycling proteins in sarcoplasmic reticulum during ischemia/reperfusion. This protection, however, does not depend on its activation of the KATP channels. Our results imply that isoflurane preconditioning may activate mechanisms that inhibit protease activity during ischemia/reperfusion.
IMPLICATIONS: Platelet function is not impaired by single and repeated oral consumption of a dietary dose of garlic in healthy volunteers. Dishes containing doses of raw garlic are unlikely to increase the risk of perioperative bleeding.
IMPLICATIONS: This pilot study attempted to validate three-dimensional transesophageal echocardiography cardiac output and assess its feasibility intraoperatively.
IMPLICATIONS: A well-implemented and monitored continuous peripheral nerve block program can be used to provide inpatient and outpatient postoperative analgesia after orthopedic procedures in children.
IMPLICATIONS: In this pediatric animal model, global end-diastolic volume (GEDV) derived from transpulmonary thermodilution was a reliable indicator of cardiac preload. Moreover, GEDV, but not pulse pressure variation or static filling pressures, accurately reflected fluid responsiveness.
IMPLICATIONS: The initial validation of a children's numeric 0 10 state anxiety measure provides clinicians with a quick assessment of anxiety in children as young as 7 yr to individualize symptom management.
IMPLICATIONS: The intraoperative infusion of esmolol compared with that of intermittent fentanyl or an infusion of remifentanil, for laparoscopic cholecystectomy, contributed to a significant decrease in the postoperative administration of fentanyl and ondansetron, and accelerated hospital discharge.
IMPLICATIONS: We determined the influence of melatonin premedication on anxiolysis, analgesia, and the rest/activity circadian rhythm in patients undergoing abdominal hysterectomy. Melatonin produced clinically relevant anxiolytic and analgesic effects, especially in the first 24 postoperative hours. It also had a positive effect on recovery of the rest/activity circadian rhythm.
IMPLICATIONS: Dexmedetomidine did not affect the spike activity recorded by electrocorticography in patients with temporal lobe epilepsy anesthetized with sevoflurane, suggesting that it can be used in these patients.
IMPLICATIONS: Pulmonary venous resistance is an important component of total pulmonary vascular resistance. Our results suggest that ketamine, etomidate, and midazolam may relax pulmonary venous smooth muscle and decrease pulmonary vascular resistance via different mechanisms.
IMPLICATIONS: Inhaled anesthetics enhanced the actions of {gamma}-aminobutyric acid (GABA) on GABAA receptors. However, at equivalent minimal alveolar anesthetic concentration multiples, the magnitudes of these actions vary dramatically among anesthetics. In general, inhaled anesthetics (aromatic and clinical) that inhibit N-methyl-d-aspartate receptor currents most, enhance GABAA receptor currents least (and vice versa).
IMPLICATIONS: Zoletil general anesthesia did not interfere with the central effect of angiotensin II or with the effects of AT1, AT2, and nitric oxide synthetase inhibitor drugs on arterial blood pressure.
IMPLICATIONS: Myoclonic movements are a common problem in unpremedicated patients during induction of anesthesia with etomidate. We have shown that IV midazolam 0.015 mg/kg administered 90 s before induction of anesthesia with etomidate is effective in reducing myoclonic movements and does not prolong recovery in unpremedicated patients after short procedures.
IMPLICATIONS: Anesthesiologists evaluated a graphical cardiovascular display while managing six simulated adverse cardiopulmonary events. They identified and treated some hemodynamic events more effectively when using the graphic display when compared with conventional monitors.
IMPLICATIONS: The supply of Xenon is relatively fixed, and recovery methods will help make xenon anesthesia cost effective. A cryogenic device has been designed, tested, and shown to be effective for recovering xenon from waste anesthetic gases.
IMPLICATIONS: A comparison of Bispectral Index and Spectral Entropy monitors during general anesthesia indicated that clinical decisions to increase, decrease, or maintain the depth of anesthesia based upon the monitored data would not be identical. There is no evidence to indicate which monitor would provide more reliable information.
IMPLICATIONS: Different mouth guards were tested in a jaw model to assess the relative ability of each guard to reduce the axial and horizontal forces applied to teeth 7 10 when a standard force (150 N) was applied directly to the left maxillary central incisor with a laryngoscope blade. All mouth guards reduced the forces applied to the teeth but some were better than others. The potential to reduce dental injury in patients warrants further study.
IMPLICATIONS: A novel Doppler-equipped vascular catheter can be used to detect the presence of air bubbles in fluid flowing past the catheter.
IMPLICATIONS: An Internet-based survey was conducted of all current academic anesthesiology chairpersons to benchmark their characteristics and accomplishments, as well as to gain insights that might be useful to aspirant department chairs. The chairs value peer-reviewed research, scholarship, and academic achievement, but do not believe that significant research experience is of great benefit to functioning as a chair.
IMPLICATIONS: Early recognition and treatment of myocardial ischemia may be a key to improving postoperative survival rates in patients presenting for elective open abdominal aortic surgery. Intensive surveillance with cardiac troponin I and early institution of aggressive {beta}-blockade is highly cost-effective, but the degree of benefit is sensitive to the efficacy of intervention.
IMPLICATIONS: Airway exchange catheters facilitate extubation of patients at risk of reintubation and difficult airway management.
IMPLICATIONS: Propofol protects against capillary endothelial damage in experimental endotoxin-induced acute lung injury.
IMPLICATIONS: Propofol as an anesthetic may offer advantages by inhibiting lipid peroxidation and inflammatory cytokine production in an animal model of gut ischemia/reperfusion-induced liver injury.
IMPLICATIONS: Dobutamine may improve diaphragmatic contractility in hypercapnia.
IMPLICATIONS: Emergency decompression of tension pneumothorax can be attempted at the level of the sternal angle at the midhemithoracic line with relative safety compared with other sites.
IMPLICATIONS: Central hypervolemia and hypovolemia both alter cerebral blood flow velocity, but only hypervolemic hemodilution impairs dynamic cerebral autoregulation in healthy humans.
IMPLICATIONS: Preischemic, but not postischemic, glycemic control with insulin improves neurologic and histopathologic outcome after transient spinal cord ischemia in rabbits. This likely reflects the glucose-decreasing effect rather than other insulin-induced effects.
IMPLICATIONS: This prospective, randomized, patient- and observer-blinded study demonstrates that mild intraoperative hypercapnia and hypocapnia do not affect blood loss or quality of surgical field during functional endoscopic sinus surgery. Maintenance of intraoperative normocapnia may be used for these patients.
IMPLICATIONS: Spinal opioids were used to alleviate the back pain intraoperatively in two patients with chronic back pain who were undergoing awake deep brain stimulator implantation.
IMPLICATIONS: Intraoperative, lower extremity forced air-warming does not prevent intraoperative hypothermia or shivering in women undergoing elective cesarean delivery under spinal anesthesia.
IMPLICATIONS: Esophageal stethoscope-obturated endotracheal tubes were comparable to thermosoftened endotracheal tubes in preventing the nasal trauma associated with nasotracheal intubation.
IMPLICATIONS: A Trachlight(R) can be used to guide a double-lumen endotracheal tube during intubation by cutting a small slit in the bronchial lumen just proximal to the pilot balloon tube.
IMPLICATIONS: This analysis of pooled data from three multicenter, randomized, active-controlled trials (n = 1941) of similar design is one of the largest studies comparing the safety and efficacy of fentanyl and morphine in an acute postoperative pain management setting. Findings from the analysis demonstrate that fentanyl delivered using the fentanyl HCl iontophoretic transdermal system and morphine administered via IV patient-controlled analgesia provide comparably safe and effective postoperative pain control for patients, regardless of age or body mass index.
IMPLICATIONS: Fentanyl iontophoretic transdermal system provides effective postoperative analgesia and may provide patients with fewer interruptions and more continuous analgesic delivery than IV patient-controlled analgesia.
IMPLICATIONS: We assessed cognitive and psychomotor performance and could demonstrate noninferiority of the patients with chronic noncancer pain receiving transdermal buprenorphine compared with that of the control group of healthy volunteers.
IMPLICATIONS: An oral dose of pregabalin 100 mg given before minor gynecologic ambulatory surgery involving only the uterus did not reduce postoperative pain.
IMPLICATIONS: Catheter-related bladder discomfort secondary to an indwelling urinary catheter is distressing. Gabapentin (600 mg) administered orally 1 h before surgery reduced the incidence and severity of catheter-related bladder discomfort, postoperative pain, the number of patients requiring fentanyl and the total postoperative fentanyl requirement.
IMPLICATIONS: Epidural anesthesia appears to be an effective option for laminectomy for spinal cord stimulator lead placement.
IMPLICATIONS: Pain in the cord-injured patient is often recalcitrant to treatment, with few effective pharmacological and nonpharmacological treatment options. We present a patient with intractable spinal cord injury pain who was successfully treated with a comprehensive pain management plan that addressed the various aspects of spinal cord injury pain. The evidence for treatment options is reviewed.
IMPLICATIONS: The antihyperalgesic effects of oxcarbazepine are mediated, at least in part, by peripheral {alpha}2A and {alpha}2C adrenoceptors in a rat model of inflammatory hyperalgesia.
IMPLICATIONS: Electroacupuncture attenuates the hyperalgesia associated with cancer pain in rats, in part through inhibiting the expression of interleukin IL-1{beta} in the spinal cord.
IMPLICATIONS: Cyclosporine has complex effects on the central and peripheral nervous systems. In rats, cyclosporine in the central nervous system enhances the hypnotic response to IV anesthetics, whereas the peripheral action of cyclosporine is the induction of hyperalgesia.
IMPLICATIONS: The incidence of transient neurological symptoms was higher with the use of single-orifice spinal needle when compared with double-orifice spinal needle.
IMPLICATIONS: Spinal anesthesia is a suitable anesthetic technique for hypoxic chemotherapeutic stop-flow perfusion, usually performed under general anesthesia. Spinal anesthesia proved superior to general anesthesia when considering anesthesia time, admission to the postanesthesia care unit, postoperative pain or nausea and vomiting.
IMPLICATIONS: We report a case of intraneural (musculocutaneous nerve) injection during axillary block that was detected only after a review of the stored images later that day. The patient remained neurologically intact. This case demonstrates that intraneural injection may occur during ultrasound-guided block and that not all intraneural injections result in neural dysfunction.
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