IMPLICATIONS: IV 8% emulsified isoflurane appears to provide anesthetic myocardial preconditioning in rabbits subjected to coronary artery occlusion and reperfusion.
IMPLICATIONS: Profound dilution-dependent impaired clot formation might be better improved with fibrinogen concentrate than with fresh frozen plasma, and supplementation with Factor XIII might be considered in some cases.
IMPLICATIONS: Accurate delivery of the set tidal volume, especially under conditions of small tidal volume and low lung compliance, is possible with an anesthesia ventilator capable of compliance compensation. When using such a ventilator, volume-controlled ventilation is a reasonable alternative to pressure-controlled ventilation and offers the advantage of a guaranteed tidal volume.
IMPLICATIONS: Prophylactic haloperidol plus dexamethasone produced a greater reduction in the incidence of postoperative nausea and vomiting than did either drug used alone, droperidol or placebo, without increasing perioperative adverse outcomes. This combination can be considered for prophylactic treatment of postoperative nausea and vomiting.
IMPLICATIONS: In a mixed surgical population, the efficacy of postoperative nausea and vomiting prophylaxis with haloperidol 1 mg was not significantly different from ondansetron 4 mg. There was no clinically important toxicity from haloperidol at this dose.
IMPLICATIONS: In a mixed surgical population, ondansetron 4 mg plus haloperidol 1 mg had greater efficacy and longer duration than ondansetron alone for postoperative nausea and vomiting prophylaxis.
IMPLICATIONS: The study identified several risk factors associated with fast-track ineligibility after monitored anesthesia care. These factors may help identify patients who are not suitable for fast-tracking. Improved fast-track protocols could increase efficient utilization of staff and physical resources, resulting in better patient care.
IMPLICATIONS: General anesthesia with halothane markedly changed important signs of local anesthetic toxicity in sheep. Cardiovascular depression predominated in anesthetized sheep while central nervous system and cardiovascular system stimulation with serious, and sometimes fatal, arrhythmias occurred in conscious sheep. This study shows that a dangerous toxic effect of local anesthetics, arrhythmias, and deaths did not occur in anesthetized sheep in this preparation, and also that outcomes of experiments using general anesthesia are likely to be different from studies of conscious animals.
IMPLICATIONS: In local anesthetic toxicity models, the influence of general anesthesia has long demanded systematic study as an experimental variable. In our whole body ovine model, anesthesia affected survival, central nervous system, and cardiovascular system responses and, as described in this paper, pharmacokinetics. This demonstration of profound influences of anesthesia as an experimental variable has fundamental implications for the interpretation of local anesthetic toxicity, and for pharmacologic study design in general.
IMPLICATIONS: Intracerebroventricular propranolol increased the convulsive dose and threshold plasma concentration of lidocaine for convulsions. Although IV propranolol also increased the convulsive dose, the plasma concentration of propranolol required for exerting anticonvulsant activity was approximately 60-fold higher than that by intracerebroventricular injection, suggesting that systemically administered propranolol exerts its anticonvulsant effect through direct actions on the brain.
IMPLICATIONS: Neurotoxicity of local anesthetics remains a concern in regional anesthesia. Given equipotent doses, the neurotoxic potential of lidocaine, bupivacaine, and ropivacaine in vitro is comparable and is brought about through activation of specific mitogen-activated protein kinases. Specific pharmacologic inhibition of these kinases attenuates neurotoxicity in vitro.
IMPLICATIONS: Lidocaine decreases intracellular pH by proton-trapping and increases intracellular sodium through a Na+-H+ exchanger.
IMPLICATIONS: Desflurane preconditioning can limit nuclear factor-{kappa}B activation induced by tumor necrosis factor (TNF)-{alpha} in vitro. Detailed analysis suggests that the early events of TNF-{alpha} cascade are targeted by desflurane.
IMPLICATIONS: Cardiac output values obtained with uncalibrated arterial pressure waveform analysis (Vigileo(R)/FloTracTM, Software 1.07) in patients undergoing liver transplantation do not correlate with pulmonary artery catheter data (percentage error of 43%), particularly in Child-Pugh grade B and C patients with low systemic vascular resistance.
IMPLICATIONS: The ability to audit fresh gas flow rates has enabled documentation of a reduction in flow rates being used. Potential factors contributing to the reduced flow rates are discussed.
IMPLICATIONS: Clinically acceptable repeatability of functional residual capacity (FRC) measurements using a small step change in inspiratory fraction of oxygen (Fio2) of 0.1 has been demonstrated in 20 postoperative cardiac patients with relatively normal pulmonary function. Acceptable measurements with a small step change in Fio2 make it feasible to perform FRC measurements at the bedside for patients with acute lung injury, although more study is needed to verify the technique in these patients.
IMPLICATIONS: Intubation using the GlideScope(R) videolaryngoscope may take longer and require more attempts in patients with high Cormack and Lehane grade at direct laryngoscopy, high upper lip bite test score, or short sternothyroid distance.
IMPLICATIONS: Planned fiberoptic-guided intubation through the I-gel supraglottic airway is described in two patients with genetic syndromes, profound intellectual disability and predicted difficult airway. I-gel airway allowed both good oxygenation and ventilation before definitive insertion of endotracheal tube.
IMPLICATIONS: In a porcine model, we compared the effect of vasopressin/epinephrine with that of a lipid emulsion on survival after bupivacaine-induced cardiac arrest. All five pigs given vasopressin/epinephrine, but none given lipid emulsion, survived. Higher coronary perfusion pressure during cardiopulmonary resuscitation by vasopressin/epinephrine may have contributed to survival rates.
IMPLICATIONS: We compared a newly developed Macintosh laryngoscope (size 3) with an incorporated suction feature versus a Macintosh laryngoscope (size 3) in a model with severe simulated upper airway hemorrhage. Although using our suction laryngoscope did not result in more rapid intubation, it significantly decreased the likelihood of esophageal intubations and could therefore be a helpful device in bleeding airway scenarios.
IMPLICATIONS: We have developed a preliminary model for labor pain as a dynamic function of cervical dilation; this model may useful as a research tool to assess the effects of covariants on first stage labor pain and the rate of change of labor pain.
IMPLICATIONS: Hypnotic and sedative effects of midazolam are associated with different patterns of regional cerebral metabolic rates for glucose decrease.
IMPLICATIONS: Co-citation analysis identified 46 active fields of research in the overall area of anesthesiology and perioperative medicine. The seminal papers were most commonly published in Anesthesiology, whereas Anesthesia & Analgesia was the most common journal for the "front papers" that provided the latest data about each research topic.
IMPLICATIONS: A higher intraoperative dose of sufentanil (>=0.6 {micro}g/kg), general anesthesia, and preoperative treatment with analgesics were significantly associated with a severe postoperative pain.
IMPLICATIONS: This study was designed to evaluate the availability of ultrasound using transverse and longitudinal median views to facilitate cervical epidural blocks. Ultrasound provided very accurate information on the agreement between ultrasound and actual epidural needle depth. In addition, longitudinal median view revealed the optimal puncture angle of the epidural needle at the insertion point. Our findings suggest that cervical epidural blocks can be of great assistance with simple ultrasound scans before puncture.
IMPLICATIONS: For arthroscopic knee surgery analgesia, intraarticular administration of combined magnesium and bupivacaine improves postoperative analgesia compared with either drug alone or to saline placebo. The time to first analgesic request was increased, the need for postoperative analgesic requirement was decreased, and pain scores were reduced.
IMPLICATIONS: Combined ultrasound and neurostimulation guidance does not decrease block time but increases the success rate of popliteal sciatic nerve block observed at 30 min compared with neurostimulation alone.
IMPLICATIONS: This study compared the postoperative analgesic efficacy of levobupivacaine and ropivacaine via patient controlled femoral nerve analgesia after total knee arthroplasty. Similar analgesia required 67% more ropivacaine, confirming the lower potency of ropivacaine previously reported.
IMPLICATIONS: Epidural ropivacaine 0.375% suppressed the stress hormone responses and sufentanil requirements perioperatively during maintenance of anesthesia but did not reduce the maintenance anesthetic requirements of propofol for patients undergoing nephrectomy.
IMPLICATIONS: Lumbar plexus block with ropivacaine and lidocaine resulted in ventricular tachycardia in a child, which immediately reverted to sinus rhythm after administration of 20% lipid emulsion.
IMPLICATIONS: For the first time, lipid infusion was successfully used for the treatment of central nervous system and cardiac toxicity after axillary brachial plexus block with mepivacaine and prilocaine.
IMPLICATIONS: We report a case of successful resuscitation with intralipid infusion after cardiovascular collapse after supraclavicular block with ropivacaine and mepivacaine. This case demonstrates the utility of lipid rescue for presumed local anesthetic toxicity during prolonged resuscitative efforts.
IMPLICATIONS: Providers who had recently completed simulation education in the management of local anesthetic cardiac toxicity participated in the successful resuscitation of a patient who suffered cardiac arrest after injection of bupivacaine during a sciatic nerve block. This experience is evidence that simulation training may improve the management of rare emergencies.
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