IMPLICATIONS: Using clinically applicable doses of aprotinin (APRO) in an intact model of ischemia-reperfusion, this study demonstrated that low doses of APRO provided protective effects on left ventricular contractility, whereas higher doses suppressed tumor necrosis factor release, but did not impart equivalent effects on left ventricular contractility. These unique findings suggest that there are distinct and independent mechanisms of action of APRO in the context of ischemia-reperfusion which are dose dependent.
IMPLICATIONS: We present a case of thromboemboli, acute right heart failure, and disseminated intravascular coagulation after the application of a topical hemostatic matrix during posterior spine fusion surgery. Clinicians need to be aware of this potentially deadly complication associated with topical hemostatic agent use in the operating room.
IMPLICATIONS: In this retrospective analysis, we found that the occurrence of postoperative renal dysfunction in neonates after cardiopulmonary bypass was more significantly predicted by the duration of cardiopulmonary bypass than by the intraoperative administration of aprotinin.
IMPLICATIONS: This study showed that fentanyl combined with propofol caused a propranolol-like effect on sinus node function tests and suggests that this anesthetic method has a potential of enhancing cardiac vagal tone.
IMPLICATIONS: This study describes the ultrasonic visualization of tracheal intubation and demonstrates that ultrasound scanning may be a suitable method to confirm tracheal tube position in young children.
IMPLICATIONS: Preoperative testing has been criticized as having little impact on perioperative outcomes. This randomized, single-blind, controlled pilot study showed that indicated preoperative testing may be eliminated without increasing the perioperative incidence of adverse events in selected patients undergoing ambulatory surgery.
IMPLICATIONS: Half of Chinese patients lose conscious response at an effect-site propofol concentration of 2.2 ng/mL and a Bispectral Index value of 58, and lose response to painful stimuli at a remifentanil effect-site concentration of 3.3 ng/mL. The propofol concentration and Bispectral Index values for loss of consciousness are lower than reported in Caucasian populations.
IMPLICATIONS: We demonstrate that anesthetics can discriminate between different types of {gamma}-aminobutyric acid receptors. This finding provides impetus to develop more selective agents for these receptors in the hope that we can increase the safety, increase the effectiveness and reduce unwanted side effects for new anesthetics.
IMPLICATIONS: Orexin A decreases ketamine-induced anesthesia time with noradrenergic neuron in rat. These findings could become a clue to clarify the mechanism of ketamine anesthesia.
IMPLICATIONS: In mesenteric resistance arteries, etomidate directly depresses the contractile response to norepinephrine or membrane depolarization by inhibiting myofilament Ca2+ sensitivity and/or intracellular Ca2+ concentration in vascular smooth muscle cells. The observed inability of low concentrations (1-3 {micro}M) of etomidate to cause significant vasodilation is consistent with minimal changes in hemodynamics during standard induction of anesthesia with etomidate in young subjects, whereas the observed direct (i.e., endothelium independent) vasodilator action of higher concentrations of etomidate might underlie systemic hypotension associated with administration of higher doses of etomidate in the clinical setting (e.g., cerebral protection).
IMPLICATIONS: If there is any causal impact from time spent at Bispectral Index under 45 on postoperative mortality, this effect is probably very weak in comparison with preexisting malignancy, other co-morbidity and age.
IMPLICATIONS: Stroke volume variations obtained with the Vigileo-FloTrac system allow continuous and automatic monitoring of fluid responsiveness in mechanically ventilated patients. This new device may have clinical impact for fluid optimization in the operating room.
IMPLICATIONS: By increasing the length of infusion lines, the time until an infusion pump triggered a pressure occlusion alarm was critically prolonged, especially at low infusion rates, as is often used for vasopressor support of unstable patients.
IMPLICATIONS: This retrospective study found that the incidence of self-reports of intraoperative awareness was not statistically different in patients receiving general anesthesia (0.023%, n = 44,006) compared with those who did not (0.03%, n = 22,885). This finding has methodological implications for the retrospective study of intraoperative awareness.
IMPLICATIONS: Published reports of awareness were reviewed to determine the risk factors, causes and the debilitating symptoms of awareness, and to translate these data into preventive procedures. Risk factors were light anesthesia and a history of awareness. Light anesthesia was the most frequent cause.
IMPLICATIONS: This randomized double-blind clinical study demonstrates that both 2% and 4% lidocaine, administered topically to the airway by a spray-as-you-go technique with the fiberoptic bronchoscope, can provide clinically acceptable intubating conditions for awake fiberoptic orotracheal intubation. As compared with 4% lidocaine, however, 2% lidocaine requires a smaller dosage and results in lower plasma concentrations.
IMPLICATIONS: Because optimal visualization of the glottis requires a considerable degree of extension at the occipitoatlantoaxial complex during conventional laryngoscopic intubation, the assessment of its extension capacity is an important predictive test for difficult laryngoscopy. Therefore, we evaluated the diagnostic accuracy of the hyomental distance ratio, defined as the ratio of the hyomental distance values at the extreme of head extension and in the neutral position, in predicting difficult laryngoscopy.
IMPLICATIONS: Perfusion index is a reliable alternative to changes in heart rate and systolic blood pressure for detecting intravascular injection of an epinephrine-containing simulated epidural test dose during propofol anesthesia in adults.
IMPLICATIONS: Short-term administration of a high oxygen concentration is not a major determinant of ventilator-induced lung injury in this experimental model. When mechanical ventilation is instituted for a limited time (for example, in the operating room or in the initial phase of trauma and septic shock resuscitation), the main focus should probably be on the avoidance of lung over-distention and not of high oxygen concentration.
IMPLICATIONS: This study shows that weaning automation with adaptive support ventilation (ASV) of non-fast-track coronary artery bypass grafting patients is feasible and safe. Time until tracheal extubation with ASV equals time until tracheal extubation with pressure-controlled/pressure-support weaning. ASV allows for frequent (automatic) switches from controlled to assisted ventilation.
IMPLICATIONS: One surgeon's cataract surgery patients place a high value on convenience and flexibility in outpatient surgery scheduling. If general, this would be achievable only if many operating rooms were available each morning.
IMPLICATIONS: The implementation of a handheld point-of-care electronic billing system improved business efficiency for an acute pain management service with an improved collection rate, decrease in charge lag days and a positive return on investment.
IMPLICATIONS: We describe the effects of the Percutwist percutaneous tracheostomy in brain-injured patients. We found the technique to be associated with no clinically significant increase in Paco2 or intracranial pressure.
IMPLICATIONS: Xenon anesthesia reduced markedly regional cerebral glucose metabolism with a concomitant smaller reduction in regional cerebral blood flow.
IMPLICATIONS: Sevoflurane exerts a preconditioning effect against ischemic cell death in the rat acute hippocampal slice, depending on both tyrosine kinases and duration of ischemia. Therefore, the duration of ischemia may represent a critical factor to account for the variability in the neuroprotective efficacy of anesthetics in experimental models.
IMPLICATIONS: We describe a case in which a patient developed posterior reversible encephalopathy syndrome after combined general-spinal anesthesia. The patient recovered spontaneously within days and the magnetic resonance findings resolved.
IMPLICATIONS: We present a distinctive Bispectral Index monitoring profile of a case of narcolepsy or Gelineau syndrome that could offer an early warning of an imminent episode, with its associated hazards, in patients with narcolepsy-cataplexy undergoing surgery under regional anesthesia.
IMPLICATIONS: Transesophageal echocardiography guidance suggests that crystalloid replacement therapy for colorectal surgery is approximately 6 mL {middle dot} kg-1 {middle dot} h-1 for open procedures and 3 mL {middle dot} kg-1 {middle dot} h-1 for laparoscopic procedures.
IMPLICATIONS: This trial does not support combining meloxicam and gabapentin for pain relief after ambulatory laparoscopic cholecystectomy, although nausea was reduced with the combination. Future procedure-specific trials are needed to further evaluate the merits of different analgesic combinations.
IMPLICATIONS: Epidural clonidine alone reduces analgesic requirement after spinal surgery, whereas preserving motor and sensory pathways.
IMPLICATIONS: Changes in arteriolar blood flow were directly observed with the use of a rabbit ear chamber attached to the auricles of rabbits. Intravital microscopic visualization of the microcirculation showed that acupuncture stimulation and phototherapy increase arteriolar diameter, blood flow velocity, and blood flow rate.
IMPLICATIONS: Bupivacaine and ropivacaine were compared with a 50:50 mixture of lidocaine-bupivacaine or lidocaine-ropivacaine for femoral-sciatic blocks. Mixture solutions induced faster onset times, reduced duration of block and provided similar pain relief. The mixed solutions had lower plasma concentrations of bupivacaine and ropivacaine. Mixtures of local anesthetics offer properties that may have some benefits over single-drug solutions.
IMPLICATIONS: We compared the influence of crystalloid/colloid versus crystalloid intravascular volume administration before spinal anesthesia on cardiac output using a thoracic electrical bioimpedance device. Volume preload with saline plus hydroxyethyl starch prevented a decrease in cardiac output but did not prevent spinal-induced hypotension in elderly patients undergoing transurethral resection of the prostate.
IMPLICATIONS: Trendelenburg position, infusion of 6% hydroxyethyl starch solution or infusion of lactated Ringer's solution, each prevented a decrease of cardiac output after spinal anesthesia. In the group of patients receiving 6% hydroxyethyl starch solution, cardiac output remained increased compared to the two other groups even after discontinuation of the infusion.
IMPLICATIONS: The anterior approach to sciatic nerve block has rarely been performed due to lack of reliable surface anatomical landmarks and technical difficulty. The present report shows that with ultrasound guidance the anterior approach to sciatic nerve block is performed as easily and reliably as the posterior approach in patients undergoing knee surgery.
IMPLICATIONS: EMLA(R) cream is bactericidal initially and has a superior bacteriostatic effect on hands only after 4 h compared to the alcohol-based disinfectant Skinsept Pur(R).
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