IMPLICATIONS: Patients at high risk for poor cerebral autoregulation during cardiopulmonary bypass have higher jugular venous oxygen tensions and saturations throughout the hypothermic period and the first minute of rewarming during cardiopulmonary bypass if pH-stat blood gas management is used instead of {alpha}-stat management.
IMPLICATIONS: Left renal blood flow measurement is feasible and reproducible using intraoperative transesophageal echocardiography in cardiac surgery for approximately 60% of patients. Assessment of right renal blood flow is unreliable due to fixed anatomic factors.
IMPLICATIONS: In healthy volunteers, therapeutic blood concentrations of milrinone inhibit adenosine diphosphate and arachadonic acid-induced platelet activation as determined by TEG(R) Platelet MappingTM.
IMPLICATIONS: Platelet transfusions given to thrombocytopenic patients have an immediate effect on whole blood coagulation, measured using rotational thromboelastometry.
IMPLICATIONS: Transcatheter aortic valve implantation is a less invasive technique used to treat aortic valvular stenosis in high-risk patients. This beating-heart technique avoids sternotomy, cardiopulmonary bypass, and aortic cross-clamping but carries specific intraoperative anesthetic concerns and complications.
IMPLICATIONS: The study suggests that the glottis rather than the cricoid is the narrowest portion of the pediatric airway. Based on airway measurements in anesthetized paralyzed children, a transition from the funnel-shaped pediatric airway to the more cylindrical adult airway could not be identified.
IMPLICATIONS: Volatile anesthetics suppress the stapedius reflex in a dose-dependent manner, suggesting that threshold measurements acquired during volatile anesthesia will overestimate the maximum comfort level, which may adversely affect the patient's adaptation to the cochlear implant. We advise against the use of volatile anesthetics for measurement of the stapedius reflex threshold during cochlear implant surgery.
IMPLICATIONS: Faster absorption and higher maximal plasma concentration of local anesthetic were observed when ultrasound was used as a guidance technique for ilioinguinal-iliohypogastric nerve blocks in children compared with the landmark-based technique. These results highlight the importance of using low volumes of local anesthetics during ultrasonographic guided ilioinguinal-iliohypogastric nerve blockade in children.
IMPLICATIONS: The cross-sectional area of the femoral vein can be effectively increased by inguinal compression in anesthetized children. Valsalva maneuver is more effective in smaller children. The reverse Trendelenburg position has little effect on the size of the femoral vein in children.
IMPLICATIONS: Transdermal scopolamine in combination with ondansetron reduces postoperative nausea and vomiting and improves patient satisfaction compared with ondansetron alone without increasing the anticholinergic-related side effects
IMPLICATIONS: Remifentanil 2 ng/mL and propofol 6 {micro}g/mL coadministration creates excellent conditions for insertion of the Cobra Perilaryngeal Airway on the first attempt, with minimal hemodynamic perturbation and a shorter duration of apnea.
IMPLICATIONS: Data from a volunteer study and a previous patient study were used to develop a new combined electroencephalogram/auditory evoked potentials parameter which can both discriminate between consciousness and unconsciousness and differentiate levels of hypnosis from awake to deep anesthesia.
IMPLICATIONS: Midazolam increases blood propofol concentrations through a reduction of the metabolic, rapid, and slow distribution clearances of propofol. In addition, mean arterial blood pressure affects the propofol pharmacokinetics such that a reduction in mean arterial blood pressure is associated with an increase in blood propofol concentration.
IMPLICATIONS: Propofol did not depress spinal dorsal horn neurons, which were depressed by isoflurane. Both anesthetics caused greater depression in the ventral horn. Picrotoxin reversed the depressive effect of propofol, but it had little or no effect on isoflurane's depressive action. In addition, decerebration did not alter propofol requirements. These data suggest that propofol produces immobility by a GABAergic action on neurons in the ventral spinal cord.
IMPLICATIONS: Three organic acids which are elevated in genetic diseases that impair consciousness have anesthetic effects in tadpoles, positively modulate glycine receptor function, and alter pressure-area isotherms of DPPC lipid monolayers.
IMPLICATIONS: The number of ineffective alarms in the medical intensive care unit can be reduced by introducing a 19-s alarm delay and identifying clinical context.
IMPLICATIONS: Neither absolute values nor dynamic changes in cardiac index can reliably be assessed by the NiccomoTM device when compared with Doppler echocardiography in resting healthy volunteers.
IMPLICATIONS: In a study of >100 patients, complete loss of consciousness was the single most frequent expectation and subjective experience of patients undergoing regional anesthesia and monitored anesthesia care. These data indicate that, from the patient's perspective, the boundary between general and nongeneral anesthesia is obscured.
IMPLICATIONS: In a simulated severely obstructed unprotected airway, the use of a flow-limited bag-valve device compared with a standard bag-valve device resulted in longer inspiratory times, higher tidal volumes, lower inspiratory pressures, and no stomach inflation, which may reduce the risk of aspiration and improve oxygenation.
IMPLICATIONS: We describe the case of a 59-yr-old patient who experienced drug fever caused by dexmedetomidine hydrochloride. Clinicians should be aware of this rare complication.
IMPLICATIONS: Intravascular volume expansion with 15 mL/kg colloid (6% hydroxyethyl starch 130/0.4) given as a preload, but not coload, significantly increases maternal cardiac output in the first 5 min after spinal anesthesia for cesarean delivery. Other measures of maternal and neonatal outcome, including maternal arterial blood pressure, were not different.
IMPLICATIONS: Three sisters with May-Hegglin anomaly and thrombocytopenia (platelet counts 14,000-100,000/mm3) were given neuraxial anesthesia for a total of seven deliveries. No complications were noted.
IMPLICATIONS: Using data from a full-scale patient simulator, we investigated the effects of different coordination patterns on clinical performance for treating a simulated episode of malignant hyperthermia. Our results could be used to develop specific training that will improve team coordination and clinical performance during routine and crisis situations.
IMPLICATIONS: The number of children receiving care from anesthesia providers for diagnostic imaging has increased to the same extent as the number of procedures performed. Utilization of anesthesia providers was highest for scans of long duration and for children 3-5 yr of age.
IMPLICATIONS: Most anesthesiologists considered an operating room to run late if it finished after a specific time of day, unrelated to the room's type of procedures or to the payment for working late. The implementation of payment to anesthesiologists for working late had no significant effect on turnover times at several times in the afternoon.
IMPLICATIONS This article is a consensus view on the possible link between Alzheimer's disease and anesthesia and the steps required to test this more definitively.
IMPLICATIONS: IV phenylephrine significantly reduced cerebral infarction volume in a rat model of complete unilateral carotid artery occlusion with severe hypotension. During hemorrhagic shock, IV administration of phenylephrine may be helpful to prevent or ameliorate postoperative stroke in patients with severe internal carotid artery disease.
IMPLICATIONS: Intubation using the flexible fiberoptic bronchoscope and Trachlight(R) produce similar degrees of cervical spine motion.
IMPLICATIONS: In conclusion, 2 mL of contrast solution can provide optimal dispersion of contrast in a ventral and longitudinal spread.
IMPLICATIONS: The sodium channel blocker amitriptyline, which is used clinically for the treatment of neuropathic pain, selectively inhibits ectopic discharge of low frequency and bursting discharge in the rat neuropathic pain model. Compounds with such selectivity may be effective for the management of neuropathic pain without potential adverse central nervous system side effects.
IMPLICATIONS: This study shows that local administration of the {alpha}7 nicotinic acetylcholine receptor agonist citicholine; cytidine-5'-diphosphate choline reduces hypersensitivity to mechanical stimuli, edema and production of the proinflammatory cytokine tumor necrosis factor-{alpha} in a model of localized inflammation. These data suggest that the local application of {alpha}7 nicotinic acetylcholine receptor agonists may be a new therapeutic tool in the management of inflammatory pain.
IMPLICATIONS: A continuous interscalene block using an ultrasound-guided posterior approach provides profound analgesia, opioid-sparing, and additional benefits after moderately painful shoulder surgery.
IMPLICATIONS: Interscalene catheters placed for shoulder surgery using an ultrasound needle end point provide postoperative analgesia of similar quality compared with that obtained when using a neurostimulation needle end point. An ultrasound end point is associated with a reduction in both needle time under the skin and procedure-related pain.
IMPLICATIONS: We describe a lateral percutaneous stellate ganglion blockade technique in rats that does not require general anesthesia and allows a more rapid evaluation of ptosis compared to the conventional posterior approach.
IMPLICATIONS: Optimal placement of thoracic epidurals improves the quality of analgesia although minimizing unwanted hemodynamic or motor side effects. This study suggests that the vertebra prominens (C7) is a more accurate surface anatomical landmark compared with the lesser wing of the scapula for thoracic epidural placement.
IMPLICATIONS: Using magnetic resonance imaging, we evaluated the accuracy of a simulated needle (perpendicular to skin) in contacting the sacral plexus and intrapelvic structures with the parasacral block technique. Only half of the needle trajectories located the sacral plexus or sciatic nerve on the first pass. The study findings question the reliability of the anatomical landmarks of the parasacral block and raise the possibility of frequent visceral puncture using this technique.
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